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Evaluation of the therapeutic potential of infrapatellar fat pad adipose-derived stem cells and their secretome for regenerating knee articular cartilage in a rat model of osteoarthritis | ||
| Iranian Journal of Veterinary Research | ||
| دوره 25، شماره 1 - شماره پیاپی 86، 2024، صفحه 33-40 اصل مقاله (585 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2024.47870.6959 | ||
| نویسندگان | ||
| S. A. Dalir1؛ A. Meimandi Parizi* 2؛ N. Tanideh* 3، 4؛ M. Kian5، 6؛ F. Nowzari1؛ A. Iraji4؛ P. Ghaemmagham7؛ N. Azarpira4، 8؛ Sh. Zare4 | ||
| 1Ph.D. Student in Veterinary Surgery, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 2Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 3Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Ph.D. Student in Comparative Biomedical Sciences, Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Student Research Committee, Shiraz | ||
| 7Department of Biostatistics, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Mesenchymal stem cell (MSC) therapy has ameliorative effects for treating knee osteoarthritis (KOA) disease. Moreover, there is a growing interest in using MSCs-derived secretome (Sec) containing trophic factors secreted by MSCs for KOA treatment. Recently, some studies have suggested that the combination of MSCs and Sec has the potential to treat the diseases. Aims: This study aimed to evaluate the ameliorative effects of combined administration of infrapatellar fat pad (IPFP)-derived MSCs, a type of adipose-derived stem cells (ASCs), for treating degenerated cartilage in a rat model of KOA. Methods: IPFP-ASCs were isolated from the IPFP of male rats. Sec was obtained from IPFP-ASCs in the fourth passage. Eight weeks after the induction of KOA by collagenase II, the rats were divided into 5 groups (n=5), including a control group with no treatment, and four experimental groups that received sodium hyaluronate (Hyalgan®, Hya), ASCs, Sec, and IPFP-ASCs+Sec, respectively by an infrapatellar injection. To perform the pathological and radiological evaluations, the animals were sacrificed 8 weeks later. Results: Our findings indicated that combined administration of the IPFP-ASCs and Sec statistically (P<0.05) improved scores of medial tibial and femoral condyles and medial fabella osteophytes. Also, it statistically (P<0.05) enhances the cartilage surface, matrix, cell distribution and population viability, and subchondral bone indices. No statistical difference was observed between IPFP-ASCs+Sec and IPFP-ASCs. Conclusion: Administration of IPFP-ASCs+Sec has a therapeutic potential to treat KOA in rats. However, there is no difference in the combined administration of IPFP-ASCs and Sec with IPFP-ASCs alone. | ||
| کلیدواژهها | ||
| Adipose-derived stem cells؛ Articular cartilage؛ Infrapatellar fat pad؛ Osteoarthritis؛ Secretome | ||
| مراجع | ||
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