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SHAMS LAHIJANI, M., AHMADZADEH, F., DABIRI, M.. (1384). TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION. , 30(1), 27-34. doi: 10.22099/ijsts.2006.2729
M. SHAMS LAHIJANI; F. AHMADZADEH; M. DABIRI. "TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION". , 30, 1, 1384, 27-34. doi: 10.22099/ijsts.2006.2729
SHAMS LAHIJANI, M., AHMADZADEH, F., DABIRI, M.. (1384). 'TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION', , 30(1), pp. 27-34. doi: 10.22099/ijsts.2006.2729
SHAMS LAHIJANI, M., AHMADZADEH, F., DABIRI, M.. TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION. , 1384; 30(1): 27-34. doi: 10.22099/ijsts.2006.2729

TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION

Iranian Journal of Science
مقاله 4، دوره 30، شماره 1، اردیبهشت 2006، صفحه 27-34    اصل مقاله (243.11 K)
نوع مقاله: Regular Paper
شناسه دیجیتال (DOI): 10.22099/ijsts.2006.2729
نویسندگان
M. SHAMS LAHIJANI* 1؛ F. AHMADZADEH2؛ M. DABIRI3
11Department of Biology, Faculty of Science, Shahid Beheshti University, Tehran, I. R. of Iran
2Department of Biology, Faculty of Science, Shahid Beheshti University, Tehran, I. R. of Iran
3Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran, I. R. of Iran
چکیده
For the first time, a spectrum of morphological abnormalities have been produced in developing
mouse embryos (N=50), by injecting (IP) 75 and 100 mg/kg of maternal body weight of a new quinazolinone
derivative, 4(3H)quinazolinone-2-propyl-2-phenylethyl(QPPE), on days 9, 10 and 11 of gestation.
Measurements of the length of the crown-rump (CR), weight of body of the embryos and placenta on day 17
showed significant growth retardation (P<0.05) with day 9 being the critical day. The severity of the changes
was dependent on the concentrations of quinazolinone, as higher doses created more abnormal embryos
(syndactily, scaphocephaly, exocephaly, microcephaly, acrocephaly, abnormal polarity in lower and upper
limbs, deviation of body axis, growth retardation) and placentas. Apparently QPPE acts on organogenesis on
a specific phase of the developmental stage by expressing genes regulating mitosis and cell proliferation.
کلیدواژه‌ها
Quinazolinone؛ Balb/C mice embryos؛ abnormalities
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