Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia | ||
Molecular Biology Research Communications | ||
دوره 13، شماره 3، 2024، صفحه 175-182 اصل مقاله (325.65 K) | ||
نوع مقاله: Original article | ||
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.49437.1955 | ||
نویسندگان | ||
Fatima Zohra Moghtit* 1؛ Wefa Boughrara2، 3؛ Samia Dorgham2؛ Ilies Koriche2؛ Imene Ouahba2؛ Amina Ammour4؛ Amine Bekadja5؛ Meriem Samia Aberkane2، 6 | ||
1Department of biology, Faculty of Science and Technology, University of Ain Temouchent-Belhadj Bouchaib-, Algeria | ||
2Service de Cytogénétique et de Biologie moléculaire de l’Etablissement Hospitalo-universitaire d’Oran (1er Novembre) | ||
3École Supérieure en Sciences Biologiques d'Oran (ESSBO), BP 1042, Saim Mohamed 31003, Oran, Algeria | ||
4Université des sciences et de la technologie d’Oran Mohamed Boudiaf | ||
5Service d’hématologie et de thérapie cellulaire de l’Etablissement Hospitalo-universitaire d’Oran (1er Novembre) | ||
6Département de pharmacie, Faculté de Médecine, Université Oran1 | ||
چکیده | ||
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (FLT3-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of FLT3-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for FLT3-ITD mutation by using polymerase chain reaction. FLT3-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the FLT3 mutated group. This preliminary study provides first-time prevalence estimates for FLT3-ITD mutation in acute myeloid leukemia patients from the West region of Algeria. | ||
کلیدواژهها | ||
FLT3؛ ITD؛ Acute myeloid leukemia؛ Prevalence؛ West of Algeria | ||
آمار تعداد مشاهده مقاله: 337 تعداد دریافت فایل اصل مقاله: 271 |