سامانه مدیریت نشریات علمی دانشگاه شیراز

Elahi, Mohammad Ehsan, Elieh-Ali-Komi, Daniel, Goudarzi, Farjam, Mohammadi‑Noori, Ehsan, Assar, Shirin, Shavandi, Mehrdad, Kiani, Amir, Elahi, Homayoin. (1403). Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients. , 13(3), 137-145. doi: 10.22099/mbrc.2024.48466.1876
Mohammad Ehsan Elahi; Daniel Elieh-Ali-Komi; Farjam Goudarzi; Ehsan Mohammadi‑Noori; Shirin Assar; Mehrdad Shavandi; Amir Kiani; Homayoin Elahi. "Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients". , 13, 3, 1403, 137-145. doi: 10.22099/mbrc.2024.48466.1876
Elahi, Mohammad Ehsan, Elieh-Ali-Komi, Daniel, Goudarzi, Farjam, Mohammadi‑Noori, Ehsan, Assar, Shirin, Shavandi, Mehrdad, Kiani, Amir, Elahi, Homayoin. (1403). 'Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients', , 13(3), pp. 137-145. doi: 10.22099/mbrc.2024.48466.1876
Elahi, Mohammad Ehsan, Elieh-Ali-Komi, Daniel, Goudarzi, Farjam, Mohammadi‑Noori, Ehsan, Assar, Shirin, Shavandi, Mehrdad, Kiani, Amir, Elahi, Homayoin. Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients. , 1403; 13(3): 137-145. doi: 10.22099/mbrc.2024.48466.1876

Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients

Molecular Biology Research Communications
دوره 13، شماره 3، 2024، صفحه 137-145    اصل مقاله (749.19 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.48466.1876
نویسندگان
Mohammad Ehsan Elahi1؛ Daniel Elieh-Ali-Komi2؛ Farjam Goudarzi3؛ Ehsan Mohammadi‑Noori4؛ Shirin Assar5؛ Mehrdad Shavandi1؛ Amir Kiani* 3، 4؛ Homayoin Elahi5
1Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
3Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Iran Medical Sciences
4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Kermanshah, Iran
5Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Silymarin is known for its anti-inflammatory and antioxidant properties. We investigated these effects on serum levels of CTRP3, Anti-CCP, and hs-CRP in individuals with Rheumatoid arthritis (RA). In this study, 42 individuals with RA were recruited and their serum specimens were collected, serum levels of hs-CRP, AntiCCP antibodies, and CTRP3 were measured using ELISA. DNA was extracted and investigated for the existence of possible new mutations in the gene encoding CTRP3 using the PCR technique; the desired fragments were then amplified and sequenced. Another blood sample was collected from the case group after taking livergol for three months (3 doses of 140 mg/day) and the tests were repeated. Anti-CCP Abs levels in the postintervention responding group decreased compared to preintervention (p<0.001) while in the non-responding group, the levels increased after the intervention compared to the levels before the intervention (p=0.019). Additionally, CTRP3 levels in the responding group increased postintervention (p=0.003), however, in the non-responding group the levels decreased postintervention when compared to preintervention (p=0.02). The responding group had significantly lower levels of hs-CRP when compared to that of preintervention (p=0.005) whereas the non-responding group had significantly higher levels of postintervention (p<0.001). Moreover, the results of sequencings of exon 6 on CTRP3 gene showed the presence of mutations in exon 6 (position 215:C>T, 338:G>A, 359:A>C, and 153:T>C). Silymarin could be used as an adjuvant in the treatment of rheumatoid arthritis.
کلیدواژه‌ها
CTRP3؛ hs-CRP؛ Anti-CCP؛ Rheumatoid Arthritis؛ Silymarin
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