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Jabraili, Masoud, Moniri-Javadhesari, Solmaz, Pouladi, Nasser, Hosseinpour-Feizi, Mohammad Ali. (1402). Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population. , 12(3), 127-131. doi: 10.22099/mbrc.2023.47622.1839
Masoud Jabraili; Solmaz Moniri-Javadhesari; Nasser Pouladi; Mohammad Ali Hosseinpour-Feizi. "Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population". , 12, 3, 1402, 127-131. doi: 10.22099/mbrc.2023.47622.1839
Jabraili, Masoud, Moniri-Javadhesari, Solmaz, Pouladi, Nasser, Hosseinpour-Feizi, Mohammad Ali. (1402). 'Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population', , 12(3), pp. 127-131. doi: 10.22099/mbrc.2023.47622.1839
Jabraili, Masoud, Moniri-Javadhesari, Solmaz, Pouladi, Nasser, Hosseinpour-Feizi, Mohammad Ali. Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population. , 1402; 12(3): 127-131. doi: 10.22099/mbrc.2023.47622.1839

Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population

Molecular Biology Research Communications
دوره 12، شماره 3، 2023، صفحه 127-131    اصل مقاله (133.46 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.47622.1839
نویسندگان
Masoud Jabraili1؛ Solmaz Moniri-Javadhesari* 1؛ Nasser Pouladi1؛ Mohammad Ali Hosseinpour-Feizi2
1Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
2Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
چکیده
Thyroid cancer is the most common malignancy of the endocrine system. LncRNAs play critical role in various cellular processes and are associated with several diseases. CCAT2 is a lncRNA molecule overexpressed in thyroid cancer. Single nucleotide polymorphisms in CCAT2 gene can cause changes in the structure and function of CCAT2 transcripts and susceptibility to several diseases. This study aimed to evaluate the association of rs6983267 in CCAT2 gene with thyroid cancer susceptibility in the Azeri population of Iran. In this "case-control" study, genomic DNA was extracted from peripheral blood of 102 individuals affected by thyroid cancer and 103 healthy individuals as controls. Genotyping was performed using TETRA-ARMS polymerase chain reaction. Statistical analysis showed no significant association between genotypes and/or alleles with the occurrence of thyroid cancer in the studied population, patients' gender, and tumor type. Nevertheless, we found that the allelic and genotypic distribution of this SNP was associated with the size of thyroid tumors in patients. It is assumed that investigating more individuals from both case and control group may further determine the genotypic and allelic frequencies of this SNP locus in Iranian-Azeri population.
کلیدواژه‌ها
Thyroid cancer؛ Polymorphism؛ rs6983267؛ lncRNA؛ CCAT2
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