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Elsayed, D. H., Abdelrazek, H. M. A., Eltamany, D. A., Ebaid, H. M., El-Nahla, A. M.. (1398). Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha. , 21(1), 46-51. doi: 10.22099/ijvr.2019.31247.4717
D. H. Elsayed; H. M. A. Abdelrazek; D. A. Eltamany; H. M. Ebaid; A. M. El-Nahla. "Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha". , 21, 1, 1398, 46-51. doi: 10.22099/ijvr.2019.31247.4717
Elsayed, D. H., Abdelrazek, H. M. A., Eltamany, D. A., Ebaid, H. M., El-Nahla, A. M.. (1398). 'Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha', , 21(1), pp. 46-51. doi: 10.22099/ijvr.2019.31247.4717
Elsayed, D. H., Abdelrazek, H. M. A., Eltamany, D. A., Ebaid, H. M., El-Nahla, A. M.. Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha. , 1398; 21(1): 46-51. doi: 10.22099/ijvr.2019.31247.4717

Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha

Iranian Journal of Veterinary Research
مقاله 8، دوره 21، شماره 1 - شماره پیاپی 70، 2020، صفحه 46-51    اصل مقاله (562.66 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2019.31247.4717
نویسندگان
D. H. Elsayed1؛ H. M. A. Abdelrazek* 2؛ D. A. Eltamany3؛ H. M. Ebaid4؛ A. M. El-Nahla2
1Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
2Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
3Nutrition and Food Science, Home Economic Department, Faculty of Education, Suez Canal University, Ismailia, Egypt
4Department of Zoology, Faculty of Sciences, Suez Canal University, Ismailia, Egypt
چکیده
Background: Implantation is a crucial period determining the success of a full pregnancy. Endocrine disruptors such as phytoestrogens (PEs) were thought to adversely influence embryonic implantations. However, the mechanism by which they upset implantation was not fully elucidated. Aims: The effect of administering soy isoflavones on the implantation of Wistar rats was studied through the detection of progesterone receptors (PR), vascular endothelial growth factor (VEGF), and estradiol receptor alpha (ER-α) protein expression at gestation day 6 (GD6). Methods: Eighteen cyclic female Wistar rats were distributed into two groups, group A: control (n=9) were fed with a casein based diet, and group B (n=9) were fed with a casein diet and gavaged 50 mg/kg/day soy isoflavones’ extract 40% starting from gestation day zero (GD0) to GD6. Feed intake, body weight (BW), body gain, and uterine weights were recorded. At the end of GD6 the number of corpora lutae (CLs) and implantation rates were recorded. Histopathology and immunohistochemistry (IHC) for PR, VEGF, and ER-α protein expression in implanted uteri were performed. Results: Soy isoflavones significantly reduced feed intake, weight gain, uterine weights CL numbers, and implantation rates of the treated pregnant dams. The endometrium of the soy treated dams showed less proliferation than that of the control. Immunostaining percentage of PR and VEGF proteins significantly reduced in soy treated dams compared to the control. However, the mean expression percentage of ER-α exhibited significant elevation in the soy treated dams in comparison to the control group. Conclusion: Implantation losses caused by soy isoflavones seemed to be due to the down regulation of PR that failed to down regulate ER-α action and decreased VEGF production.
کلیدواژه‌ها
ER-α؛ Implantation؛ Isoflavones؛ Progesterone؛ VEGF
مراجع

Achache, H and Revel, A (2006). Endometrial receptivity markers, the journey to successful embryo implantation. Hum. Reprod. Update. 12: 731-746.

Amal, M; Abdoon, A; Ismail, A; Heba, M; Hend, M and Gihan, G (2014). Teratogenic effects of dietary genistein and daidzein are mediated by over regulation of Oct-4 and down regulation of Cdx2 expression in post implantation Albino rat embryos. Int. J. Chem. Environ. Biol. Sci., 2: 129-135.

Amini, L; Tehranian, N; Movahedin, M; Tehrani, FR and Ziaee, S (2015). Antioxidants and management of polycystic ovary syndrome in Iran: a systematic review of clinical trials. Iran. J. Reprod. Med., 13: 1-8.

Bancroft, JD and Gamble, M (2008). Theory and practice of histological techniques. 6th Edn., Churchill Livingstone, UK, Elsevier Health Sciences. PP: 53-134.

Borini, A; Tarozzi, N; Bizzaro, D; Bonu, M; Fava, L; Flamigni, C and Coticchio, G (2006). Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART. Hum. Reprod., 21: 2876-2881.

Branham, WS; Dial, SL; Moland, CL; Hass, BS; Blair, RM; Fang, H; Shi, L; Tong, W; Perkins, RG and Sheehan, DM (2002). Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor. J. Nutr., 132: 658-664.

Casanova, M; You, L; Gaido, KW; Archibeque-Engle, S; Janszen, DB and Heck, HA (1999). Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. Toxicol. Sci., 51: 236-244.

Cha, J; Sun, X and Dey, SK (2012). Mechanisms of implantation: strategies for successful pregnancy. Nat. Med., 18: 1754-1767.

Chandrareddy, A; Muneyyirci-Delale, O; McFarlane, SI and Murad, OM (2008). Adverse effects of phytoestrogens on reproductive health: a report of three cases. Complement Ther. Clin. Pract., 14: 132-135.

Cline, JM; Register, TC and Clarkson, TB (2002). Comparative effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on the reproductive tract of female cynomolgus monkeys. Menopause. 9: 242-252.

Douglas, NC; Zimmermann, RC; Tan, QK; Sullivan-Pyke, CS; Sauer, MV; Kitajewski, JK and Shawber, CJ (2014). VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment. Vasc. Cell. 6: 16-26.

Ebaid, HM; Elgawish, RAR; Abdelrazek, HM; Gaffer, G and Tag, HM (2016). Prenatal exposure to soy isoflavones altered the immunological parameters in female rats. Int. J. Toxicol., 35: 274-283.

Elgawish, RAR; Rahman, HGA and Abdelrazek, HMA (2015). Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis. Toxicol. Rep., 2: 1149-1156.

Gaffer, GG; Elgawish, RA; Abdelrazek, HMA; Ebaid, HM and Tag, HM (2018). Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats. Toxicol. Rep., 5: 296-301.

Goddard, LM; Murphy, TJ; Org, T; Enciso, JM; Hashimoto-Partyka, MK; Warren, CM; Domigan, CK; McDonald, A; He, H; Sanchez, LA; Allen, NC1; Orsenigo, F; Chao, LC; Dejana, E; Tontonoz, P; Mikkola, HK and Iruela-Arispe, ML (2014). Progesterone receptor in the vascular endothelium triggers physiological uterine permeability pre-implantation. Cell. 156: 549-562.

Helmy, S; Emarah, H and Abdelrazek, H (2014). Estrogenic effect of soy phytoestrogens on the uterus of ovariectomized female rats. Clin. Pharmacol. Biopharm., S2:001 doi:10.4172/2167-065X.S2-001.

Hiremath, SP; Badami, S; Hunasagatta, SK and Patil, SB (2000). Antifertility and hormonal properties of flavones of Striga orobanchioides. Eur. J. Pharmacol., 391: 193-197.

Jefferson, WN; Padilla-Banks, E and Newbold, RR (2005). Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses. Biol. Reprod., 73: 798-806.

Jefferson, WN; Padilla-Banks, E and Newbold, RR (2006). Studies of the effects of neonatal exposure to genistein on the developing female reproductive system. JAOAC Int., 89: 1189-1196.

Kallela, K; Heinonen, K and Saloniemi, H (1984). Plant oestrogens; the cause of decreased fertility in cows. A case report. Nord Vet. Med., 36: 124-129.

Kodaman, PH; Arici, A and Seli, E (2004). Evidence-based diagnosis and management of tubal factor infertility. Curr. Opin. Obstet. Gynecol., 16: 221-229.

Matsumoto, H and Sato, E (2006). Uterine angiogenesis during implantation and decidualization in mice. Reprod. Med. Biol., 5: 81-86.

Meena, R and Sreenivasula Reddy, P (2014). Do phytoestrogens affect reproductive performance in male rats. J. Infertil. Reprod. Biol., 2: 1-5.

Messina, M (2010). A brief historical overview of the past two decades of soy and isoflavone research. J. Nutr., 140: 1350S-1354S.

Morley, F; Axelsen, A and Bennett, D (1966). Recovery of normal fertility after grazing on oestrogenic red clover. Aust. Vet. J., 42: 204-206.

Mueller, MD; Vigne, JL; Minchenko, A; Lebovic, DI; Leitman, DC and Taylor, RN (2000). Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β. Proc. Natl. Acad. Sci. U.S.A., 97: 10972-10977.

Norwitz, ER; Schust, DJ and Fisher, SJ (2001). Implantation and the survival of early pregnancy. N. Engl. J. Med., 345: 1400-1408.

Oludare, G and Iranloye, B (2016). Implantation and pregnancy outcome of Sprague-Dawley rats fed with low and high salt diet. Middle East Fertil. Soc. J., 21: 228-235.

Piesta, A; Maj, T and Chełmońska-Soyta, A (2009). The influence of mating on estrogen receptor alpha protein level in spleen and uterine macrophages in female mice. Reprod. Biol., 9: 225-240.

Rabbani, ML and Rogers, PA (2001). Role of vascular endothelial growth factor in endometrial vascular events before implantation in rats. Reproduction. 122: 85-90.

Rockwell, LC; Pillai, S; Olson, CE and Koos, RD (2002). Inhibition of vascular endothelial growth factor/vascular permeability factor action blocks estrogen-induced uterine edema and implantation in rodents. Biol. Reprod., 67: 1804-1810.

Sepehr, E; Cooke, G; Robertson, P and Gilani, GS (2007). Bioavailability of soy isoflavones in rats Part I: application of accurate methodology for studying the effects of gender and source of isoflavones. Mol. Nutr. Food Res., 51: 799-812.

Setchell, KD (2001). Soy isoflavones benefits and risks from nature’s selective estrogen receptor modulators (SERMs). J. Am. Coll. Nutr., 20: 354S-362S.

Soucy, NV; Parkinson, HD; Sochaski, MA and Borghoff, SJ (2005). Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol. Sci., 90: 230-240.

Spósito, DR; Santos Jr, AR; Spósito, D and Santos Jr, A (2011). Histochemical study of early embryo implantation in rats. Int. J. Morphol., 29: 187-192.

Suzuki, S; Nakashima, N; Kageyama, M and Yamagata, K (2017). A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1β in endometrial epithelial cells. Reprod. Biol., 17: 259-267.

Szkudelska, K; Nogowski, L and Szkudelski, T (2000). Genistein affects lipogenesis and lipolysis in isolated rat adipocytes. J. Steroid Biochem. Mol. Biol., 75: 265-271.

Tan, W; Chen, L; Guo, L; Ou, X; Xie, D and Quan, S (2014). Relationship between macrophages in mouse uteri and angiogenesis in endometrium during the peri-implantation period. Theriogenology. 82: 1021-1027.

Thongon, N; Boonmuen, N; Suksen, K; Wichit, P; Chairoungdua, A; Tuchinda, P; Suksamrarn, A; Winuthayanon, W and Piyachaturawat, P (2017). Selective estrogen receptor modulator (SERM)-like activities of diarylheptanoid, a phytoestrogen from curcuma comosa, in breast cancer cells, pre-osteoblast cells, and rat uterine tissues. J. Agric. Food Chem., 65: 3490-3496.

Wade, GN (1975). Some effects of ovarian hormones on food intake and body weight in female rats. J. Comp. Physiol. Psychol., 88: 183-193.

Wetendorf, M and DeMayo, FJ (2012). The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network. Mol. Cell. Endocrinol., 357: 108-118.

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