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Mozhdeganloo, Z., Moghadam Jafari, A., Koohi, M.K., Heidarpour, M.. (1394). Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C. , 17(1), 31-35. doi: 10.22099/ijvr.2016.3600
Z. Mozhdeganloo; A. Moghadam Jafari; M.K. Koohi; M. Heidarpour. "Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C". , 17, 1, 1394, 31-35. doi: 10.22099/ijvr.2016.3600
Mozhdeganloo, Z., Moghadam Jafari, A., Koohi, M.K., Heidarpour, M.. (1394). 'Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C', , 17(1), pp. 31-35. doi: 10.22099/ijvr.2016.3600
Mozhdeganloo, Z., Moghadam Jafari, A., Koohi, M.K., Heidarpour, M.. Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C. , 1394; 17(1): 31-35. doi: 10.22099/ijvr.2016.3600

Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C

Iranian Journal of Veterinary Research
مقاله 6، دوره 17، شماره 1 - شماره پیاپی 54، 2016، صفحه 31-35    اصل مقاله (176.26 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2016.3600
نویسندگان
Z. Mozhdeganloo1؛ A. Moghadam Jafari2؛ M.K. Koohi3؛ M. Heidarpour* 4
1Post-Graduate Student, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
4Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده
The objective of this study was to investigate the propensity of permethrin (PTN) to induce oxidative stress and changes in enzyme activities in liver of rainbow trout and its possible attenuation by vitamin C. Forty-eight fish were randomly assigned to 1 of 6 treatment groups and their livers were used for liver perfusion method: control (0 μgL-1 permethrin and 0 mgL-1 vitamin C), PTN-0.16 (0.16 μgL-1 permethrin), PTN-0.32 (0.32 μgL-1 permethrin), PTN-0.64 (0.64 μgL-1 permethrin), Vit. C (17.2 mgL-1 vitamin C), and PTN-0.64 + Vit. C (0.64 μgL-1 permethrin and 17.2 mgL-1 vitamin C). Results obtained showed that permethrin significantly (P<0.05) increased ALT, AST and LDH activities in the liver perfusion medium and malondialdehyde (MDA) level in liver tissue. The values of reduced glutathione (GSH) and total antioxidant capacity (FRAP) in the liver tissue were significantly decreased due to permethrin administration. Pearson’s correlation analysis revealed a positive correlation between MDA concentration and ALT, AST and LDH activities in the permethrin groups, suggesting that the enhanced lipid peroxidation may be linked to hepatic damage caused by permethrin. On the other hand, treatment with vitamin C in the PTN-0.64 + Vit. C group increased the values of GSH and FRAP, and decreased the level of MDA and the activities of hepatic enzymes, when compared to the PTN-0.64 group. The present study revealed that vitamin C could ameliorate permethrin-induced oxidative damage by decreasing lipid peroxidation and altering antioxidant defense system in liver of rainbow trout.
کلیدواژه‌ها
Liver؛ Oxidative stress؛ Permethrin؛ Rainbow trout؛ Vitamin C
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