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Tabatabaei, M., Moazzeni Jula, G. R., Jabbari, A. R., Esmailzadeh, M.. (1385). Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia. , 8(1), 40-44. doi: 10.22099/ijvr.2007.2706
M. Tabatabaei; G. R. Moazzeni Jula; A. R. Jabbari; M. Esmailzadeh. "Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia". , 8, 1, 1385, 40-44. doi: 10.22099/ijvr.2007.2706
Tabatabaei, M., Moazzeni Jula, G. R., Jabbari, A. R., Esmailzadeh, M.. (1385). 'Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia', , 8(1), pp. 40-44. doi: 10.22099/ijvr.2007.2706
Tabatabaei, M., Moazzeni Jula, G. R., Jabbari, A. R., Esmailzadeh, M.. Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia. , 1385; 8(1): 40-44. doi: 10.22099/ijvr.2007.2706

Pathogenicity and immunogenicity of native and mutant strains of Pasteurella multocida, the causative agents of haemorrhagic septicaemia

Iranian Journal of Veterinary Research
مقاله 6، دوره 8، شماره 1 - شماره پیاپی 18، 2007، صفحه 40-44    اصل مقاله (133.69 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2007.2706
نویسندگان
M. Tabatabaei* 1؛ G. R. Moazzeni Jula2؛ A. R. Jabbari2؛ M. Esmailzadeh3
1Department of Microbiology, Faculty of Veterinary Medicine, University of Urmia, Urmia, Iran
2Department of Aerobic Vaccine Production, Razi Vaccine and Serum Research Institute, Karadj, Iran
3Department of Biotechnology, Razi Vaccine and Serum Research Institute, Karadj, Iran
چکیده
Haemorrhagic septicaemia (HS) is a fatal systemic disease of cattle and buffaloes. Some control is
achieved with administration of alum-precipitated or oil-adjuvanted killed whole-cell vaccines injected
subcutaneously. These vaccines, however, provide only short-term immunity and for effective use, they
should be administered annually. We constructed an aroA attenuated derivative of a Pasteurella multocida
serotype B:2 strain by allelic exchange of the native aroA sequence with aroA sequences disrupted with a
kanamycin resistance cassette. This strain was confirmed to be aroA mutant by PCR. The aroA derivative
was highly attenuated for virulence in a mouse model of HS and rabbits. Mouse and rabbit challenge
experiments showed that i.p. or i.m. vaccination of an aroA strain completely protected mice or rabbits
against challenge with a high dose (>1000 LD50) of the parent strain.
کلیدواژه‌ها
Pasteurella multocida؛ Live vaccine؛ aroA mutant؛ Haemorrhagic septicaemia
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