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Central effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks | ||
Iranian Journal of Veterinary Research | ||
مقاله 7، دوره 11، شماره 1 - شماره پیاپی 30، 2010، صفحه 51-55 اصل مقاله (113.63 K) | ||
نوع مقاله: Full paper (Original article) | ||
شناسه دیجیتال (DOI): 10.22099/ijvr.2010.175 | ||
نویسندگان | ||
A. Ghazanfari Moghaddam1؛ H. Jonaidi2؛ M. Abbasnejad3؛ M. M. Yaghoobi4؛ H. Sepehri1 | ||
1Department of Biology, College of Sciences, University of Tehran, Tehran, Iran | ||
2Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran | ||
3Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran | ||
4Department of Biotechnology, International Center for Science and High Technology and Environmental Sciences, Mahan, Iran | ||
چکیده | ||
Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found in the gut and brain of mammals. The present study was carried out to investigate the central effect of OXM on food intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula was stereotaxically implanted into the right lateral ventricle of each bird. Two experiments were conducted on free-feeding (non-fasted) and 6-h fasted broilers. In each experiment, eight birds were used in a replicated 4 × 4 Latin square design. The birds were given an intracerebroventricular (ICV) injection of different doses of mammalian OXM. Intracerebroventricular injection of OXM at doses of 1.5, 3 and 6 nmol significantly (P<0.05) decreased food intake for 3 h post injection in both non-fasted and fasted chicks. It may be concluded that central OXM may exert a suppressive effect on food intake in chicks. | ||
کلیدواژهها | ||
Oxyntomodulin؛ Food intake؛ Intracerebroventricular injection؛ Chick | ||
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