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The role of the histaminergic system on the inhibitory effect of ghrelin on feed intake in broiler chickens | ||
Iranian Journal of Veterinary Research | ||
مقاله 5، دوره 11، شماره 1 - شماره پیاپی 30، 2010، صفحه 38-45 اصل مقاله (132.75 K) | ||
نوع مقاله: Full paper (Original article) | ||
شناسه دیجیتال (DOI): 10.22099/ijvr.2010.173 | ||
نویسندگان | ||
M. Taati* 1؛ H. Nayebzadeh1؛ H. Khosravinia2؛ J. Cheraghi3 | ||
1Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran | ||
2Department of Animal Sciences, Faculty of Agriculture, Lorestan University, Khorramabad, Iran | ||
3Department of Physiology, College of Veterinary Medicine, Ilam University, Ilam, Iran | ||
چکیده | ||
This study was conducted to investigate the possible involvement of the histaminergic system in the mediation of ghrelin-induced feeding behavior in broiler chickens. In the trial 1, the effect of intracerebroventricular (ICV) injection of ghrelin on feed intake was examined in 3-h feed-deprived broiler chickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine (an H1 receptor antagonist) and cimetidine (an H2 receptor antagonist) prior to ghrelin injection, respectively. Cumulative feed intake was measured at 3-h post injections. Infusion of ghrelin (0.3, 0.6 and 1.2 nmol) decreased feed intake dosedependently (P<0.05). Pre-treatment of chlorpheniramine (100 μg) attenuated the inhibitory effect of ghrelin on feed intake (P<0.05), while such an effect was not noticed by pre-injection of cimetidine (100 μg). The results suggest that there is an interaction between ghrelin and the histaminergic system (through H1 receptors) on control of feed intake in broiler chickens. | ||
کلیدواژهها | ||
Ghrelin؛ Histaminergic system؛ Feed intake؛ Chicken | ||
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