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Prevalence of genetic polymorphisms of methylenetetrahydrofolate reductase C677T and angiotensin I-converting enzyme (insertion/deletion) in Sétif population, Algeria | ||
| Molecular Biology Research Communications | ||
| مقاله 3، دوره 2، 1-2، تیر 2013، صفحه 19-27 اصل مقاله (71.85 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2013.1469 | ||
| نویسندگان | ||
| Bakhouche Houcher* 1؛ Samia Begag1؛ Zahira Houcher1؛ Afife Karabiyik2؛ Yonca Egin2؛ Nejat Akar2 | ||
| 1Faculty of Life and Nature Sciences, University of Sétif, Sétif 19000, Algeria | ||
| 2Paediatric Molecular Genetics Department of Ankara University Medical School, Ankara, Turkey | ||
| چکیده | ||
| The aim of the present study was to assess the frequencies of angiotensin I-converting enzyme (ACE; OMIM: 106180) and methylenetetrahydrofolate reductase (MTHFR; OMIM: 607093) polymorphisms in the Algerian population to further facilitate investigations on possible associations with various pathologies. The study was carried out on 146 apparently healthy individuals (65 males, 81 females) who were randomly selected from an Algerian population of the Setif region (north-eastern Algeria). Their age ranged from 24 to 48 years. Using polymerase chain reaction based methods, genotypic frequencies of MTHFR C677T (rs. 1801133) and ACE I/D (rs. 1799752) polymorphisms were determined. No significant difference was found between genders regarding the distribution of ACE I/D and MTHFR C677T polymorphisms. In general, the prevalence of the D allele of the ACE polymorphism was 70.5%. The study population was in the Hardy-Weinberg equilibrium (Chi-Square=0.55, df=1, P=0.758). The allelic frequency of the 677T allele (for MTHFR C677T polymorphism) was 35.3%. The study population was in the Hardy-Weinberg equilibrium (Chi-Square=1.05, df=1, P=0.304). The surprisingly high incidence of minor alleles of the polymorphisms among our population requires further studies in vascular and other diseases. | ||
| کلیدواژهها | ||
| ACE؛ Algerian Population؛ MTHFR؛ Polymorphism | ||
| مراجع | ||
|
1. Kumar RS, Kusari J, Roy SM, Soofer RL, Sen GC. Structure of testicular angiotensin-converting enzyme. J Biol Chem 1989;264:16754-16758.
2. Lieberman J, Sastre A. Serum angiotensin-converting enzyme: elevations in diabetes mellitus. Ann Intern Med 1980;93:825-826.
3. Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Suzuki Y, Mezzano S, Plaza JJ, Egido J. Role of renin-angiotensin system in vascular diseases. Hypertension 2001;38: 382-1393.
4. Mattei MG, Hubert C, Alhenc-Gelas F, Roeckel N, Corvol P, Soubrier F. Angiotensin I-converting enzyme gene is on chromosom 17. Cytogent Cell Gene 1989;51:1041.
5. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin-converting enzyme gene (DCPI) (dipepdidylcarboxypeptidase I). Nucleic Acids Res 1992;20:1433.
6. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-1346.
7. Velasquez MT, Bhathena SJ, Striffler JS, Thibault N, Scalbert E. Role of angiotensin-converting enzyme inhibition in glucose metabolism and renal injury in diabetes. Metabolism 1998;47:7-11.
8. Mehri S, Koubaa N, Nakbi A, Hammami S, Chaaba R, Mahjoub S, Zouari B, Abid M, Ben Arab S, Baudin B, Hammami M. Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients. Clin Biochem 2010;43:259-266.
9. Loscalzo J. Homocysteine trials: clear outcomes for complex reasons. N Engl J Med 2006;354:1429-1632.
10. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, Van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolte reductase. Nat Genet 1995;10:11-13.
11. Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003;101:2483-2488.
12. Rieder MJ, Taylor SL, Clark AG, Nickerson D. Sequence variation in the human angiotensin converting enzyme. Nature Genet 1999;22:59-62.
13. Comas D, Calafell F, Benchemsi N, Helal A, Lefranc G, Stoneking M, Batzer MA, Bertranpetit J, Sajantila A. Alu insertion polymorphisms in NW Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gibraltar Straits. Hum Genet 2000;107:312-319.
14. Rice GI, Foy CA, Grant PJ. Angiotensin-converting enzyme and angiotensin II type 1-receptor gene polymorphisms and risk of ischaemic heart disease. Cardiovasc Res 1999;41:746-753.
15. Fatini C, Gensini F, Sticchi E, Battaglini B, Prisco D, Fedi S, Brunelli T. ACE DD genotype: an independent predisposition factor to venous thromboembolism. Eur J Clin Invest 2003;33:642-647
16. Algasham A, Ismail D, Dewaidar M, Settin AA Methylenetetrahydrofolate reductase and angiotensin-converting enzyme gene polymorphisms among Saudi population from Qassim region. Genet Test Mol Biomarkers 2009;13:817-820.
17. Salem AH, Batzer MA. High frequency of the D allele of the angiotensin-converting enzyme gene in Arabic populations. BMC Res Notes 2009;2: 99.
18. Staessen JA, Ginocchio G, Wang JG, Saavedra AP, Soubrier F, Vlietinck R, Fagard R. Genetic variability in the renin-angiotensin system: Prevalence of alleles and genotypes. J Cardiovasc Risk 1977;4:401-422.
19. Saab YB, Gard PR, Overall ADJ. The geographic distribution of the ACE II genotype: A novel finding. Genet Res 2007;89:259-267.
20. Shimizu E, Hashimoto K, Ohgake S, Koizumi H, Okamura N, Koike K. Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:99-103.
21. Sakuma H, Hirata RD, Hirata MH. Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals. J Clin Lab Anal 2004;18:309-316.
22. Obineche EN, Frossard PM, Bokhari AM. An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs. Hypertens Res 2001;24:635-639.
23. Akar N, Aras O, Omurlu K, Cin S. Deletion polymorphism at the angiotensin-converting enzyme gene in Turkish patients with coronary artery disease. Scand J Clin Lab Inves 1998,58:491-495.
24. Gesang L, Liu G, Cen W, Qiu C, Zhuoma C, Zhuang L, Ren D, Pincuo Z, Chan Y. Angiotensin-converting enzyme gene polymorphism and its association with essential hypertension in a Tibetan population. Hypertens Res 2002;25:481-485.
25. Das M, Pal S, Ghosh A. Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and hypertension in adult Asian Indians: a population-based study from Calcultta, India. Hum Biol 2008;80:303-312.
26. Kennon B, Petrie JR, Small M, Connell JM Angiotensin-converting enzyme gene and diabetes mellitus. Diabet Med 1999;16:448-458.
27. Arzu-Ergen H, Hatemi H, Agachan B, Camlica H, Isbir T. Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients. Exp Mol Med 2004;36:345-350.
28. Pfohl M, Koch M, Prescod S, Haase KK, Haring HU, Karsch KR. Angiotensin I-converting enzyme gene polymorphism, coronary artery disease and myocardial infraction. An angiographically controlled study. Eur Heart J 1999;20:1318-1325.
29. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH. A prospective evaluation of an angiotensin-converting enzyme gene polymorphism and the risk of ischemic heart disease. N EnglJ Med 1995;332:706-711.
30. Zaman MM, Yoshiike N, Date C, Yokoyama T, Matsumura Y, Ikemoto S, Tanaka H. Angiotensin converting enzyme genetic polymorphism is not associated with hypertension in a cross-sectional sample of a Japanese population: The Shibata study. J Hypertens 2001;19:47-53.
31. Grammer TB, Renner W, Von Karger S, Boehm BO, Winkelmann BR, Maerz W. The angiotensin–I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography (The Ludwingshaften Risk and Cardiovascular Health Study). Mol Genet Metab 2006;88:378-383.
32. Acartük E, Attila G, Bozkurt A, Akpinar O, Matyar S, Seydaoglu G. Insertion/deletion polymorphism of the angiotensin converting enzyme gene in coronary artery disease in Southern Turkey. J Biochem Mol Biol 2005;38:486-490.
33. Akra-Ismail M, Fakhoury-Makki R, Nakkash-Chmaisse H, Kazma A, Khoueiry-Zgheib N. Association between angiotensin-converting enzyme insertion/deletion genetic polymorphism and hypertension in a sample of Lebanese patients. Genet Test Mol Biomarkers 2010;14:787-792.
34. Guillen M, Corella D, Portoles O, Gonzalez JI, Mulet F, Saiz C. Prevalence of methylenetetrahydrofolate reductase 677C>T mutation in the Mediterranean Spanish population. Association with cardiovascular risk factors. Eur J Epidemiol 2001;17:255-261.
35. Hessner MJ, Dinauer DM, Kwiatkowski R, Neri B, Raife TJ. Age-dependent prevalence of vascular disease-associated polymorphisms among 2689 volunteer blood donors. Clin Chem 2001;47:1879-1884.
36. Bertina RM, Reitsma RH, Rosendaal FR, Vandenbroucke JP. Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis. Thromb Haemost 1995;74:449-453.
37. Li C, Zhang C, Qiu S, Lu X, Zeng Y, Wu H, Chen W, Luo W, Liu J. Polymorphisms of ACE-I and MTHFR genes and genetic susceptibility of ischemic stroke. Zhongua Yixue Zazhi 2002;82:1046-1049.
38. Wang HY, Li CM, Wang Z, Yang F. Relationships between polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase genes and genetic susceptibility to pregnancy induced hypertension. Zhonghua Fu Chan Ke Za Zhi 2004;39:369-372.
39. Joshi G, Pradhan S, Mittal B. Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. J Neurol Sci 2009; 277:133-137.
40. Goracy I. Polymorphism of genes coding for angiotensin I converting enzyme and methylenetetrahydrofolate reductase in patients with ischemic heart disease. Ann Acad Med Stetin 2004;46:97-108. | ||
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