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Hormonal, biochemical and hematological changes in neonatal calves with sepsis induced by enteritis | ||
| Iranian Journal of Veterinary Research | ||
| دوره 27، شماره 1 - شماره پیاپی 94، 2026، صفحه 71-80 اصل مقاله (329.81 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2025.52264.7798 | ||
| نویسندگان | ||
| M. Sezer* 1؛ E. Akyüz1؛ Y. U. Bati1؛ M. Kuru2؛ G. Gökce1 | ||
| 1Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey | ||
| 2Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey | ||
| چکیده | ||
| Background: Diarrhea is one of the most important problems seen in calves during the neonatal period. Sepsis caused by diarrhea is the main cause of death. In the case of sepsis, many hormonal, hematological and biochemical changes occur in calves. It is extremely important to evaluate these parameters together. Aims: The present study aimed to investigate hormonal, biochemical, and hematological changes in neonatal calves affected by septic enteritis to obtain more information about the pathogenesis of sepsis. Methods: The study included a sepsis group consisting of 40 calves aged 0-15 days with enteritis, and a control group composed of 20 clinically and hematologically healthy calves of similar age. Calves presenting with enteritis, anorexia, severe dehydration, and general condition deterioration were examined, and those meeting the sepsis criteria were included in the study. Hematological, hormonal, and biochemical measurements were performed on blood samples obtained from the calves. Additionally, pathogenic agents causing enteritis were identified using immunochromatographic methods on fecal samples. Results: In the sepsis group, creatinine, total protein, and urea levels, as well as the enzymatic activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and creatine kinase (CK) were significantly higher compared with the healthy group (P<0.05), while cholesterol levels were significantly lower (P<0.001). The total leukocyte count (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and granulocyte count were also found to be higher in the sepsis group compared with the control group (P<0.05). Furthermore, calves in the sepsis group were determined to be hypothermic, tachycardic and tachypneic compared with the control group (P<0.05). In the sepsis group, notable reductions in free T3, free T4 and erythropoietin (EPO) levels were observed (P<0.05). However, cortisol, insulin, and adrenocorticotropic hormone (ACTH) levels were significantly higher than those in the healthy group (P<0.05). Conclusion: Sepsis causes significant hematological, biochemical and hormonal changes in neonatal calves. | ||
| کلیدواژهها | ||
| Calf؛ Hematology؛ Hormone؛ Neonatal period؛ Sepsis | ||
| مراجع | ||
|
Akyüz, E and Gökce, G (2021). Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis. Trop. Anim. Health Prod., 53: 354-362.
Akyüz, E; Naseri, A; Erkılıç, EE; Makav, M; Uzlu, E; Kırmızıgül, AH and Gökce, G (2017). Neonatal calf diarrhea and sepsis. KAUFBED. 10: 181-191.
Akyüz, E; Ölmez, M; Kuru, M; Merhan, O; Makav, M; Öğün, M; Bozukluhan, K; Naseri, A; Uzlu, E and Gökce, G (2020). Evaluation of some biochemical parameters in female Gurcu goats before, during and after pasture. Dicle Univ. J. Fac. Vet. Med., 13: 33-38.
Al, M and Balıkçı, E (2012). Diagnosis of rotavirus, coronavirus, E. coli K99 and Cryptosporidium parvum in calves with neonatal diarrhea using rapid test kits and the relationship between enteropathogen and maternal immunity. Fırat Univ. Vet. J. Health Sci., 26: 73-78.
Andanson, S; Boissy, A and Veissier, I (2020). Conditions for assessing cortisol in sheep: the total form in blood v. the free form in saliva. Animal. 14: 1916-1922.
Bal, D (2019). Etiological studies on neonatal calf diarrhea in Manisa region. MSc Thesis, Afyon Kocatepe University, Afyonkarahisar. PP: 7-6
Başer, DF and Civelek, T (2013). Correlation between venous acid-base status and renal function in neonatal calves with acute diarrhea. Kocatepe Vet. J., 6: 25-31.
Brückmann, A; Höck, C; Linke, K; Hennies, M and Schallenberger, E (2000). Alterations of growth hormone, cortisol, luteinizing hormone, and insulin concentrations in early-postnatal calves affected with diarrhea. Domest. Anim. Endocrinol., 18: 187-197.
Cho, YI and Yoon, KJ (2014). An overview of calf diarrhea-infectious etiology, diagnosis, and intervention. J. Vet. Sci., 15: 1-17.
Constable, PD (2007). General medicine. In: Radostits, OM (Ed.), Veterinary medicine. (10th Edn.), Philadelphia, USA, Saunders Elsevier. PP: 51-58.
Çorapsız, MF and Birdane, FM (2023). Evaluation of thyroid and some blood-serum parameters in neonatal calf diarrhea. MSc Thesis, Afyon Kocatepe University, Afyonkarahisar. PP: 1-20.
De Castro, R; Ruiz, D; Lavín, BA; Lamsfus, JA; Vazquez, L; Montalban, C; Marcano, G; Sarabia, R; Paz-Zulueta, M; Blanco, C and Santibanez, M (2019). Cortisol and adrenal androgens as independent predictors of mortality in septic patients. PLoS One. 14: e0214312-e0214325.
De Clue, A (2017). Sepsis and the systemic inflammatory response syndrome. In: Ettinger, SJ; Feldman, EC and Cote, E (Eds.), Textbook of veterinary ınternal medicine. (8th Edn.), St. Louis, Missouri, Saunders. PP: 523-527.
den Brinker, M; Joosten, KF; Visser, TJ; Hop, WC; de Rijke, YB; Hazelzet, JA; Boonstra, VH and Hokken-Koelega, AC (2005). Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. J. Clin. Endocrinol. Metab., 90: 5613-5620.
Dengler, F; Hammon, HM; Liermann, W; Görs, S; Bachmann, L; Helm, C and Ulrich, R and Delling, C (2023). Cryptosporidium parvum competes with the intestinal epithelial cells for glucose and impairs systemic glucose supply in neonatal calves. Vet. Res., 54: 40-56.
El-Deeb, W; Iacob, O; Fayez, M; Elsohaby, I; Alhaider, A; Mkrtchyan, HV; Ibrahim, A and Alhumam, N (2022). Assessment of the immune response of clinically infected calves to Cryptosporidium parvum infection. Agriculture. 12: 1151-1164.
Eroğlu, MS and Kırbaş, A (2020). Systemic inflammatory response syndrome and sepsis. Fırat Univ. Vet. J. Health Sci., 34: 61-67.
Eschbach, JW; Mladenovic, J; Garcia, JF; Wahl, PW and Adamson, JW (1984). The anemia of chronic renal failure in sheep. Response to erythropoietin-rich plasma in vivo. J. Clin. Invest., 74: 434-41.
Gold, JR; Divers, TJ; Barton, MH; Lamb, SV; Place, NJ; Mohammed, HO and Bain, FT (2007). Plasma adrenocorticotropin, cortisol, and adrenocorticotropin/ cortisol ratios in septic and normal-term foals. J. Vet. Intern. Med., 21: 791-796.
Greenspan, FS and Gardner, DG (2004). Basic and clinical endocrinology. 7th Edn., New York, Mc Graw Hill. PP: 1-976.
Gülşen, N and Umucalılar, HD (2009). Calf nutrition and nutritional diseases. 1st Edn., Konya, Turkey, Konya SU Printing Office. PP: 91-100.
Hajimohammadi, A; Roshan-Ghasrodashti, A; Forouzesh, SM and Saeb, M (2015). A survey on relationships between thyroid hormone levels and clinical findings in dairy calf diarrhea. Vet. Sci. Dev., 5: 5835-5838
Kahl, S; Elsasser, T and Blum, J (2000). Effect of endotoxin challenge on hepatic 5′-deiodinase activity in cattle. Domest. Anim. Endocrinol., 18: 133-143.
Kozat, S and Tuncay, İ (2018). Prevalence of rotavirus, coronavirus, cryptosporidium spp, Escherichia coli K99 and Giardia lamblia agents in calves with neonatal diarrhea in Siirt region. Van Vet. J., 29: 17-22.
Lekkou, A; Mouzaki, A; Siagris, D; Ravani, I and Gogos, CA (2014). Serum lipid profile cytokine production and clinical outcome in patients with severe sepsis. J. Crit. Care. 29: 723-727.
Mebis, L and Van den Berghe, G (2011). Thyroid axisfunction and dysfunction in critical illness. Best Pract. Res. Clin. Endocrinol. Metab., 25: 745-757.
Melis, MJ; Miller, M; Peters, VBM and Singer, M (2023). The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction. Clin. Sci., 137: 707-725.
Melmed, S; Polonsky, KS; Larsen, PR and Kronenberg, HM (2011). Williams textbook of endocrinology E-Book. 12th Edn., Philadelphia, USA, Elsevier Health Sciences. PP: 545-577.
Merhan, O; Bozukluhan, K; Gökçe, G and Yılmaz, O (2016). Investigation of haptoglobin, ceruloplasmin and some biochemical parameter levels in diarrheic calves. Fırat Univ. Vet. J. Health Sci., 30: 195-198.
Perello, M; Friedman, T; Paez-Espinosa, V; Shen, X; Stuart, RC and Nillni, EA (2006). Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 147: 2705-2716.
Rahman, M; Haque, M; Towhidul, A; Amin, N; Parveen, H; Al Mahmuda, N and Abbas G (2016). Serum erythropoietin level in chronic kidney disease patients with anemia: A baseline study at Chittagong Medical College, Chittagong, Bangladesh. J. Clin. Exp. Med., 4: 20-25. Şahal, M; Terzi, OS; Ceylan, E and Kara, E (2018). Calf diarrhea and prevention methods. Lalahan Hay. Araşt. Enst. Derg., 58: 41-49.
Savaş, HB and Gültekin, F (2017). Insulin resistance and its clinical significance. Med. J. SDU, 24: 116-125.
Sezer, M (2021). Studies on sTREM-1, Mr-Pro-Adrenomedullin (Mr-Pro-ADM), clinical biochemistry and hematology in calves suspected of sepsis. Ph.D. Thesis, Kafkas University, Kars. PP: 1-40
Sezer, M and Gökce, G (2024). sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis. J. Hell. Vet. Med. Soc., 74: 6481-6490.
Silverstein, D and Otto, CM (2012). Sepsis. In: Greene, CE (Ed.), Infectious diseases of the dog and cat. (4th Edn.), St. Louis, Missouri, USA, Saunders Elsevier. PP: 359-369.
Squires, EJ (2003). Applied animal endocrinology. 1st Edn., Trowbridge, UK, CABI Publishing. PP: 1-234
Tamion, F; Le Cam-Duchez, V; Menard, JF; Girault, C; Coquerel, A and Bonmarchand, G (2005). Serum erythropoietin levels in septic shock. Anaesth. Intens. Care. 33: 578-584.
Tokgöz, BS; Özdemir, R; Turut, N; Mirioğlu, M; İnce, H; Mahanoğlu, B; Yoldas, A and Tuzcu, N (2013). Determination of morbidity and mortality rates and risk factors of neonatal calf infections observed in the Adana region. AVKAE. J., 3: 7-14.
Tothova, C; Nagy, O; Kovac, G and Nagyova, V (2016). Changes in the concentrations of serum proteins in calves during the first month of life. J. Appl. Anim. Res., 44: 338-346.
Traş, B; Yazar, E and Elmas, M (2012). Veterinary medicine. 1st Edn., Olgun-Çelik Printing, Konya. PP: 125-140.
Uzlu, E; Karapehlivan, M; Çitil, M; Gökçe, E and Erdoğan, HM (2010). Investigation of serum sialic acid and certain biochemical parameters in calves exhibiting diarrhea symptoms. Van Vet. J., 21: 83-86.
Van den Berghe, G; Teblick, A; Langouche, L and Gunst, J (2022). The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions. E-Bio Med., 84: 104284-104294.
Walden, AP; Young, JD and Sharples, E (2010). Bench to bedside: A role for erythropoietin in sepsis. Crit. Care. 14: 227-235.
Whittaker, AC and Gallagher, S (2019). Caregiving alters immunity and stress hormones: a review of recent research. Curr. Opin. Behav. Sci., 28: 93-97.
Yüceer, B (2008). The effect of colostrum on immunity, growth, disease incidence, and survival rate in calves that received colostrum. MSc Thesis, Ankara University, Ankara, Turkey. PP: 1-8
Zeybek, S (2013). Time-dependent effects of intravenous isotonic sodium bicarbonate administration on venous acid-base status and renal function in neonatal calves with acute diarrhea. MSc Thesis, Afyon Kocatepe Univ, Afyonkarahisar. PP: 39-46. | ||
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