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Therapeutic potential of 4-OH-coumarin in neuroblastoma: cellular, molecular, and epigenetic insights | ||
| Molecular Biology Research Communications | ||
| دوره 15، شماره 2، 2026، صفحه 103-116 اصل مقاله (973.67 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2025.54532.2228 | ||
| نویسندگان | ||
| Çağrı Öner* 1، 2؛ Halise Elif Kulakac3؛ Damla Kolcuoglu1؛ Ertuğrul Çolak4 | ||
| 1Department of Medical Biology, Medical Faculty, Kırklareli University, Kırklareli, Türkiye | ||
| 2Department of Medical Biology and Genetics, Medical Faculty, Maltepe University, İstanbul, Türkiye | ||
| 3Medical Faculty, Maltepe University, İstanbul, Türkiye | ||
| 4Department of Biostatistics, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Türkiye | ||
| چکیده | ||
| The effect of 4-OH-Coumarin, a warfarin derivate, on the cellular characteristics and metastasis of SH-SY5Y neuroblastoma cells and HUVEC cells was aimed to determine. After IC50 concentrations were detected wound healing and hematoxylin-eosin assays were performed on both cell lines. Ki-67, hTERT, PI3K, AKT, mTOR, HIF-1α, PINK1, Parkin, Cyt C, p53 gene expressions and piR-651, piR-823, miR-126 expressions were determined by RT-PCR. The proliferation, wound closure and survival decreased after 4-OH-Coumarin treatment (p<0.001). Ki-67, hTERT, PI3K, mTOR, HIF-1α, PINK1, Parkin, Cyt C and piR-823 expressions were decreased, while AKT, p53, piR-651, and miR-126 increased on SH-SY5Y (p<0.001). AKT (p<0.05), Parkin, and piR-651 expressions increased on only HUVEC cells (p<0.001). We believe that the study of various molecules that are secondary metabolites such as 4-OH-Coumarin may provide valuable data to observe the effects and mechanisms of new therapeutics that have the potential to be used for cancer treatment. | ||
| کلیدواژهها | ||
| 4-OH-Coumarin؛ Hematoxylin/Eosin؛ Migration؛ Neuroblastoma؛ Proliferation | ||
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