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Antimicrobial resistance patterns of multidrug resistant ESBL-producing Escherichia coli and Klebsiella pneumoniae isolated from sheep and goats in Punjab, India | ||
| Iranian Journal of Veterinary Research | ||
| دوره 26، شماره 2 - شماره پیاپی 91، 2025، صفحه 170-178 اصل مقاله (320.04 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2025.51659.7682 | ||
| نویسندگان | ||
| A. Mushtaq* 1؛ T. S. Rai1؛ A. K. Arora1؛ M. Chandra1؛ J. S. Bedi2؛ J. Singh3 | ||
| 1Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India | ||
| 2Centre of One Health, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India | ||
| 3Department of Veterinary and Animal Husbandry Extension, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India | ||
| چکیده | ||
| Background: A serious community concern worldwide is the alarming spread of enterobacteria producing extended-spectrum beta-lactamase (ESBL) enzymes. The food-producing animals harbor ESBL-producing enterobacterales and disseminate these resistant strains of pathogens through faeces. ESBL producers are multidrug-resistant phenotype posing a challenge to the disease management in clinical settings. Aims: The objective of the present study was to investigate the prevalence of ESBL-producing Escherichia coli, and Klebsiella pneumoniae from fecal samples (n=340) of healthy (n=300) and diarrhoeic (n=40) sheep and goats and hand swabs (n=70) of animal handlers. Methods: Presumptive ESBL producing bacteria were identified using ESBL agar, which were then confirmed by combined disc method (CDM). Genotypic detection of beta-lactamase, quinolones and tetracycline resistance genes was done using PCR. Results: A total of 156 enteropathogenic E. coli were recovered from sheep (79/170) and goats (77/170). Phenotypic antimicrobial resistance data revealed high resistance against cefazolin with 91.13% and 84.41% in sheep and goats, respectively. Low resistance was recorded against carbapenems. All the ESBL producing isolates revealed a multiple antibiotic resistance (MAR) index >0.2. The predominant β-lactamase gene found was the blaTEM detected in 110 (70.51%) isolates followed by blaCTXM in 80 (51.28%) isolates. Conclusion: The findings of the present study revealed a high prevalence of multidrug resistance E. coli and K. pneumoniae in food-producing animals. It represents an issue of concern and requires serious need for implementing effective approaches to reduce multidrug resistance in commensal organisms. | ||
| کلیدواژهها | ||
| Antimicrobial resistance؛ Combined disc method؛ Extended-spectrum beta-lactamase؛ Multiple antibiotic resistance | ||
| مراجع | ||
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