| تعداد نشریات | 24 |
| تعداد شمارهها | 929 |
| تعداد مقالات | 8,346 |
| تعداد مشاهده مقاله | 16,803,502 |
| تعداد دریافت فایل اصل مقاله | 14,117,643 |
Unusual histopathological features of a uterine leiomyosarcoma in a dog | ||
| Iranian Journal of Veterinary Research | ||
| دوره 26، شماره 1 - شماره پیاپی 90، 2025، صفحه 88-93 اصل مقاله (965.57 K) | ||
| نوع مقاله: Scientific report | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2025.50585.7473 | ||
| نویسندگان | ||
| T. R. Akhila1؛ T. N. Ganesh2؛ A. Azimah3؛ M. K. Kok4؛ A. Salleh* 4، 5 | ||
| 1MVSc in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 2Ph.D. in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 3DVM, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 4Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia | ||
| 5Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia | ||
| چکیده | ||
| Background: Uterine leiomyosarcoma is a malignant neoplasm arising from leiomyocytes in the uterus. Case description: A 12-year-old mixed-breed intact female dog was presented with vaginal bleeding for the past 2 weeks. Abdominal ultrasonography revealed a mixed echogenic mass in the uterus, and right lateral abdominal radiography showed a large mid-abdominal mass. Exploratory celiotomy was performed, revealing a solid mass in the entire uterine body and both uterine horns. Ovariohysterectomy was performed and the uterine mass sample was microscopically examined. Findings/treatment and outcome: The mass was composed of a dense proliferation of neoplastic cells that display two morphologic features; spindloid and epithelioid appearances. Additionally, chondroid-like matrix was noted. Both components were negative for cytokeratin AE1/AE3, and strongly positive for vimentin. The spindloid component was strongly positive for α-SMA, while the epithelioid-like component was moderately positive for alpha-smooth muscle actin. These findings are suggestive of a leiomyosarcoma. Although the recovery immediately following surgery was smooth and without complications, the dog’s condition worsened over the following month, ultimately leading to euthanasia. Conclusion: This report describes the histopathologic features and clinical outcome of an unusual variant of uterine leiomyosarcoma in a dog. | ||
| کلیدواژهها | ||
| Dog؛ Immunohistochemistry؛ Pathology؛ Uterine leiomyosarcoma | ||
| مراجع | ||
|
Agnew, DW and Maclachlan, NJ (2017). Tumors of the genital systems. In: Meuten, DJ (Ed.), Tumors in domestic animals. (5th Edn.), Ames, Iowa, John Wiley & Sons. PP: 689-722.
Barozzi, MCM; Saba, CF and Gendron, KP (2021). CT characteristics of uterine and vaginal mesenchymal tumours in dogs. J. Small Anim. Pract., 62: 293-299.
Boisclair, J and Dore, M (2001). Uterine angiolipoleiomyoma in a dog. Vet. Pathol., 38: 726-728.
Bray, JP (2016). Soft tissue sarcoma in the dog - Part 1: A current review. J. Small Anim. Pract., 57: 510-519.
Carvalho, MI; Silva-Carvalho, R; Pires, I; Prada, J; Bianchini, R; Jensen-Jarolim, E and Queiroga, FL (2016). A comparative approach of tumor-associated inflammation in mammary cancer between humans and dogs. Biomed. Res. Int., 2016: 4917387.
Chapel, DB; Nucci, MR; Quade, BJ and Parra-Herran, C (2022). Epithelioid leiomyosarcoma of the uterus: modern outcome-based appraisal of diagnostic criteria in a large institutional series. Am. J. Surg. Pathol., 46: 464-475.
Fraser, C; Keong Kok, M; Shameha Abdul Razak, I; Puspitasari, Y and Salleh, A (2024). Diagnostic challenge in veterinary pathology: Metastatic mammary tumor in a female tiger (Panthera tigris). Vet. Pathol., 61: 508-511.
Greten, FR and Grivennikov, SI (2019). Inflammation and cancer: triggers, mechanisms, and consequences. Immunity. 51: 27-41.
Grivennikov, SI; Greten, FR and Karin, M (2010). Immunity, inflammation, and cancer. Cell. 140: 883-899.
Hagman, R (2014). Diagnostic and prognostic markers for uterine diseases in dogs. Reprod. Domest. Anim., 49: 16-20.
Kazmierczak, J; Sugai, NJ; Withowski, KE; Jonatan, A; LeRoith, T and Cecere, JT (2023). Case report: A case of oviductal and uterine leiomyosarcoma in an 11-year-old dog. Front. Vet. Sci., 10: 1227799.
Kurman, RJ; Carcangiu, ML and Herrington, CS (2014). WHO classification of tumours of female reproductive organs. 4th Edn., Lyon, France: International Agency for Research on Cancer.
Liptak, JM and Forrest, LJ (2007). Soft tissue sarcomas. In: Withrow, SJ and MacEwen, EG (Eds.), Withrow and MacEwen’s small animal clinical oncology. (4th Edn.), St. Louis, Missouri: Elsevier. PP: 425-454.
Maruyama, S; Yamazaki, M; Abé, T; Cheng, J; Saku, T and Tanuma, JI (2023). Hypoxia-induced biosynthesis of the extracellular matrix molecules, perlecan and fibronectin, promotes the growth of pleomorphic adenoma cells in vitro models. Biomedicines. 11: 2981.
Mazlan, M; Khairani-Bejo, S; Hamzah, H; Nasruddin, NS; Salleh, A and Zamri-Saad, M (2021). Pathological changes, distribution and detection of Brucella melitensis in foetuses of experimentally-infected does. Vet. Q., 41: 36-49.
Miettinen, M (2014). Immunohistochemistry of soft tissue tumours–review with emphasis on 10 markers. Histopathology. 64: 101-118.
Mohan, D; Maiti, SK; Shivaraju, S; Ramith, KR; Sangeetha, P; Bindhuja, BV and Kumar, N (2018). Surgical management of multiple uterine tumours in a dog. MOJ Anat. Physiol., 5: 117-118.
Patsikas, M; Papazoglou, LG; Jakovljevic, S; Papaioannou, NG; Papadopoulou, PL; Soultani, CB; Chryssogonidis, IA; Kouskouras, KA; Tziris, NE and Charitanti, AA (2014). Radiographic and ultrasonographic findings of uterine neoplasms in nine dogs. J. Am. Anim. Hosp. Assoc.; 50: 330-337. Pena, FJ; Gines, JA; Duque, J; Vieitez, V; Martinez-Perez, R; Madejón, L; Martinez, IN; Moran, JM and Fernández-García, S (2006). Endometrial adeno-carcinoma and mucometra in a 6-year-old Alaska Malamute dog. Reprod. Domest. Anim., 41: 189-190.
Percival, A; Singh, A; Zur Linden, RA; Watrous, G; Patten, S; Valverde, A and Ratsep, E (2018). Massive uterine lipoleiomyoma and leiomyoma in a miniature poodle bitch. Can. Vet. J., 59: 845-850.
Richards, HG; McNeil, PE; Thompson, H and Reid, SWJ (2001). An epidemiological analysis of a canine-biopsies database compiled by a diagnostic histopathology service. Prev. Vet. Med., 51: 125-136.
Russo, M; England, GCW; Catone, G and Marino, G (2021). Imaging of canine neoplastic reproductive disorders. Animals. 11: 1213.
Salleh, A; Zainuddin, ZZ; Mohamed Tarmizi, MR; Yap, KC and Zamri-Saad, M (2020). Two variants of uterine leiomyoma in Malaysia’s last Sumatran rhinoceros (Dicerorhinus sumatrensis). Vet. Q., 40: 250-257.
Serin, G; Aydogan, A; Yaygingul, R and Tunca, R (2010). Uterine leiomyosarcoma in a dog: a case report. Vet. Med. (Praha), 55: 405-408.
Tsioli, VG; Gouletsou, PG; Loukopoulos, P; Zavlaris, M and Galatos, AD (2011). Uterine leiomyosarcoma and pyometra in a dog. J. Small Anim. Pract., 52: 121-124. | ||
|
آمار تعداد مشاهده مقاله: 538 تعداد دریافت فایل اصل مقاله: 480 |
||