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Unusual histopathological features of a uterine leiomyosarcoma in a dog | ||
| Iranian Journal of Veterinary Research | ||
| دوره 26، شماره 1 - شماره پیاپی 90، 2025، صفحه 88-93 اصل مقاله (965.57 K) | ||
| نوع مقاله: Scientific report | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2025.50585.7473 | ||
| نویسندگان | ||
| T. R. Akhila1؛ T. N. Ganesh2؛ A. Azimah3؛ M. K. Kok4؛ A. Salleh* 4، 5 | ||
| 1MVSc in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 2Ph.D. in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 3DVM, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia | ||
| 4Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia | ||
| 5Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia | ||
| چکیده | ||
| Background: Uterine leiomyosarcoma is a malignant neoplasm arising from leiomyocytes in the uterus. Case description: A 12-year-old mixed-breed intact female dog was presented with vaginal bleeding for the past 2 weeks. Abdominal ultrasonography revealed a mixed echogenic mass in the uterus, and right lateral abdominal radiography showed a large mid-abdominal mass. Exploratory celiotomy was performed, revealing a solid mass in the entire uterine body and both uterine horns. Ovariohysterectomy was performed and the uterine mass sample was microscopically examined. Findings/treatment and outcome: The mass was composed of a dense proliferation of neoplastic cells that display two morphologic features; spindloid and epithelioid appearances. Additionally, chondroid-like matrix was noted. Both components were negative for cytokeratin AE1/AE3, and strongly positive for vimentin. The spindloid component was strongly positive for α-SMA, while the epithelioid-like component was moderately positive for alpha-smooth muscle actin. These findings are suggestive of a leiomyosarcoma. Although the recovery immediately following surgery was smooth and without complications, the dog’s condition worsened over the following month, ultimately leading to euthanasia. Conclusion: This report describes the histopathologic features and clinical outcome of an unusual variant of uterine leiomyosarcoma in a dog. | ||
| کلیدواژهها | ||
| Dog؛ Immunohistochemistry؛ Pathology؛ Uterine leiomyosarcoma | ||
| مراجع | ||
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