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Najafi, Samaneh, Salehi, Zivar, Mashayekhi, Farhad, Saidi-Saedi, Hamid. (1404). Expression patterns of circRFX3 and miR-587 in colorectal cancer patients. , 14(3), 243-248. doi: 10.22099/mbrc.2025.52016.2080
Samaneh Najafi; Zivar Salehi; Farhad Mashayekhi; Hamid Saidi-Saedi. "Expression patterns of circRFX3 and miR-587 in colorectal cancer patients". , 14, 3, 1404, 243-248. doi: 10.22099/mbrc.2025.52016.2080
Najafi, Samaneh, Salehi, Zivar, Mashayekhi, Farhad, Saidi-Saedi, Hamid. (1404). 'Expression patterns of circRFX3 and miR-587 in colorectal cancer patients', , 14(3), pp. 243-248. doi: 10.22099/mbrc.2025.52016.2080
Najafi, Samaneh, Salehi, Zivar, Mashayekhi, Farhad, Saidi-Saedi, Hamid. Expression patterns of circRFX3 and miR-587 in colorectal cancer patients. , 1404; 14(3): 243-248. doi: 10.22099/mbrc.2025.52016.2080

Expression patterns of circRFX3 and miR-587 in colorectal cancer patients

Molecular Biology Research Communications
دوره 14، شماره 3، 2025، صفحه 243-248    اصل مقاله (315.92 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2025.52016.2080
نویسندگان
Samaneh Najafi1؛ Zivar Salehi* 2؛ Farhad Mashayekhi2؛ Hamid Saidi-Saedi3
1Department of Biology, University Campus 2, University of Guilan, Rasht, Iran
2Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
3Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
چکیده
Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has established a connection between circRNAs and cancer progression. The objective of this project was to evaluate the expression levels of a newly discovered circRNA, circRFX3 (hsa_circRFX3_003), along with its target gene, miR-587. The study involved 60 patients diagnosed with Colorectal cancer (CRC) and 60 healthy individuals as controls. Total RNA was extracted from blood samples, converted into cDNA, and analyzed using qRT-PCR. The findings revealed an up-regulation of miR-587 and a down-regulation of circRFX3 in the blood samples of CRC patients. An inverse relationship was observed between the levels of miR-587 and circRFX3; however, there was no significant difference in circRFX3 expression levels between stages I+II and stages III+IV. The levels of miR-587 expression were linked to tumor size and location. Both circRFX3 and miR-587 play significant roles in the pathophysiology of CRC; however, additional research is necessary to elucidate their specific contributions to CRC development.    
کلیدواژه‌ها
circRFX3؛ miR-587؛ CRC؛ Gene expression؛ Real-time PCR
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