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HIV-1 reverse transcriptase subtyping revealed CRF35-AD as a current subtype in the northeast of Iran | ||
| Molecular Biology Research Communications | ||
| دوره 14، شماره 3، 2025، صفحه 237-241 اصل مقاله (251.29 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2025.52193.2089 | ||
| نویسندگان | ||
| Zahra Mazaheri1؛ Masoud Youssefi* 1، 2 | ||
| 1Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Previously, the sequence of the HIV-1 reverse transcriptase gene was analyzed to identify mutations associated with drug resistance. We statistically analyzed the relationship between a set of additional data and increasing mutations. Existing sequences were also phylogenetically analyzed. Of all patients tested for phylogenetic tree analysis, one individual had the F subtype, two had the CRF01-AE strain, and two had the A subtype. Phylogenetic tree analysis revealed that HIV-1 CRF35-AD was the most prevalent subtype (88.6%) among the cases studied. The number of treatment discontinuations (r=0.621, df=20, p=0.002) and the duration of treatment (r=0.452, df=20, p=0.035) were significantly correlated with an increase in mutations. | ||
| کلیدواژهها | ||
| HIV؛ Phylogenetic tree؛ Reverse Transcriptase؛ Drug Resistance Mutation؛ Iran | ||
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آمار تعداد مشاهده مقاله: 138 تعداد دریافت فایل اصل مقاله: 135 |
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