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Computational analysis of Ayurvedic herbs to explore their potential role as anti-cervical cancer agents | ||
| Molecular Biology Research Communications | ||
| دوره 14، شماره 2، 2025، صفحه 129-141 اصل مقاله (1.18 M) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2024.51173.2038 | ||
| نویسندگان | ||
| Suhani Dange1؛ Neha Aggarwal1؛ Rivi Verma2؛ Yashika Sinha1؛ Sonakshi Dadhiya1؛ Gagan Mittal3؛ Ruchi Sachdeva* 1 | ||
| 1Department of Bioinformatics, Goswami Ganesh Dutta Sanatan Dharma College, Sector-32, Chandigarh, India | ||
| 2Department of Biotechnology, Panjab University, Chandigarh, India | ||
| 3Department of Zoology, RKSD College, Kaithal, Haryana, India | ||
| چکیده | ||
| Cervical cancer is one of the common types of cancer in women. Treatment regimens include use of chemotherapy but it leads to certain side effects thereby creating a need for safer therapeutic options. Ayurveda has a great potential to provide better treatment strategies. In this study, computational approaches have been employed to investigate the molecular mechanism of anti-cervical cancer Ayurvedic herbs. Initially, Ayurvedic plants possessing anti-cervical cancer activities were obtained from literature. Bioactive compounds present in such plants were evaluated for drug-likeliness, biological functions and associations with cancer-related pathways. This resulted in the most promising drug-like bioactive compounds which were found to target cancer pathways like microRNA and proteoglycans, Human papillomavirus infection. Anti-cervical cancer activity possessing herbs derived from the study include Camellia sinensis, Equisetum arvense, Rosmarinus officinalis. Major bioactive compounds extracted from the enlisted herbs that contribute in promoting anti-cervical cancer effects include allicin, apigenin, and mataresinol. Overall, our study has provided insights into the scientific mechanism behind anti-cervical cancer activities of the indigenous herbs of Ayurveda. In addition, this study has also highlighted key bioactive compounds which have a potential in targeting cancer related pathways and thus can further be utilized to devise better therapeutics to cure cervical cancer. | ||
| کلیدواژه‌ها | ||
| Anti-cervical cancer؛ Ayurvedic herbs؛ Pathways؛ Protein targets؛ Bioactive compounds | ||
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