| تعداد نشریات | 24 |
| تعداد شمارهها | 859 |
| تعداد مقالات | 7,646 |
| تعداد مشاهده مقاله | 13,578,486 |
| تعداد دریافت فایل اصل مقاله | 11,684,905 |
Morphology and Mechanical Properties of 3D Porous PLA/PCL Scaffolds | ||
| Iranian Journal of Materials Forming | ||
| دوره 11، شماره 3، مهر 2024، صفحه 21-27 اصل مقاله (1.29 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22099/ijmf.2024.51296.1305 | ||
| نویسندگان | ||
| M. Dolatkhahan؛ M. Peiravi؛ Z. Sherafat* | ||
| Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran | ||
| چکیده | ||
| Fabrication and evaluation of tissue engineering scaffolds is a new research field that has significant applications in medicine. Various polymers have been considered for the fabrication of bone scaffolds due to their biocompatibility, biodegradability, and excellent mechanical properties. Polycaprolactone and polylactic acid are both biodegradable and biocompatible polymers, nevertheless, polylactic acid is brittle and polycaprolactone is hydrophobic, which reduces cell adhesion on the surface. Therefore, the mixture of these two polymers can be an effective way to develop a new biomaterial. In the present study, PLA/PCL scaffolds with different PLA/PCL weight ratios were fabricated by solvent casting/particle leaching method. To evaluate morphology, wettability, and mechanical properties of the scaffolds, scanning electron microscopy (SEM), contact angle goniometer, compression and tensile test were respectively used. The SEM images of the samples showed that all the samples have porosity in the range of 70-85% with a size of 250-500 micrometers, which is suitable for infiltration, proliferation and growth of cells. The measurement of the contact angle of the samples showed that the presence of PLA has increased the hydrophilicity of composite samples. PCL/PLA samples have less ductility and higher stiffness than pure PCL. However, the weak interface of PLA and PCL has caused some composite samples to have less strength than PCL. PCL/PLA scaffold can be a promising candidate for bone tissue engineering. | ||
| کلیدواژهها | ||
| Polycaprolactone؛ Polylactic acid؛ Solvent casting/particle leaching؛ Bone tissue engineering | ||
| مراجع | ||
|
[1] Amini, A. R., Laurencin, C. T., & Nukavarapu, S. P. (2012). Bone tissue engineering: recent advances and challenges. Critical Reviews™ in Biomedical Engineering, 40(5), 363-408. https://doi.org/10.1615/CritRevBiomedEng.v40.i5.10
[2] Wang, W., & Yeung, K. W. (2017). Bone grafts and biomaterials substitutes for bone defect repair: A review. Bioactive Materials, 2(4), 224-247. https://doi.org/10.1016/j.bioactmat.2017.05.007
[3] Fang, R., Zhang, E., Xu, L., & Wei, S. (2010). Electrospun PCL/PLA/HA based nanofibers as scaffold for osteoblast-like cells. Journal of Nanoscience and Nanotechnology, 10(11), 7747-7751. https://doi.org/10.1166/jnn.2010.2831
[4] Qu, H., Fu, H., Han, Z., & Sun, Y. (2019). Biomaterials for bone tissue engineering scaffolds: A review. RSC Advances, 9(45), 26252-26262. https://doi.org/10.1039/C9RA05214C
[5] Ghassemi, T., Shahroodi, A., Ebrahimzadeh, M. H., Mousavian, A., Movaffagh, J., & Moradi, A. (2018). Current concepts in scaffolding for bone tissue engineering. Archives of Bone and Joint Surgery, 6(2), 90-99. https://doi.org/10.22038/abjs.2018.26340.1713
[6] Suamte, L., Tirkey, A., Barman, J., & Babu, P. J. (2023). Various manufacturing methods and ideal properties of scaffolds for tissue engineering applications. Smart Materials in Manufacturing, 1, 100011. https://doi.org/10.1016/j.smmf.2022.100011
[7] Farzamfar, S., Naseri-Nosar, M., Sahrapeyma, H., Ehterami, A., Goodarzi, A., Rahmati, M., Ahmadi Lakalayeh, G., Ghorbani, S., Vaez, A., & Salehi, M. (2019). Tetracycline hydrochloride-containing poly (ε-caprolactone)/poly lactic acid scaffold for bone tissue engineering application: In vitro and in vivo study. International Journal of Polymeric Materials and Polymeric Biomaterials, 68(8), 472-479. https://doi.org/10.1080/00914037.2018.1466133
[8] Perez-Puyana, V., Jiménez-Rosado, M., Romero, A., & Guerrero, A. (2020). Polymer-based scaffolds for soft-tissue engineering. Polymers, 12(7), 1566. https://doi.org/10.3390/polym12071566
[9] Abodunrin, O. D., Bricha, M., & El Mabrouk, K. (2024). Developments in 3D-printed polymeric Materials and Bioactive Materials Integration for Biomedical Applications. In Reference Module in Materials Science and Materials Engineering. Elsevier. https://doi.org/10.1016/B978-0-323-95486-0.00028-4
[10] Mateos-Timoneda, M. A. (2009). Polymers for bone repair. In Bone repair biomaterials (pp. 231-251). Woodhead Publishing. https://doi.org/10.1533/9781845696610.2.231
[11] Patrício, T., Domingos, M., Gloria, A., D'Amora, U., Coelho, J. F., & Bártolo, P. J. (2014). Fabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineering. Rapid Prototyping Journal, 20(2), 145-156. https://doi.org/10.1108/RPJ-04-2012-0037
[12] Rodan, G. A. (1992). Introduction to bone biology. Bone, 13, S3-S6. https://doi.org/10.1016/S8756-3282(09)80003-3
[13] Ning, L., & Chen, X. (2017). A brief review of extrusion‐based tissue scaffold bio‐printing. Biotechnology Journal, 12(8), 1600671. https://doi.org/10.1002/biot.201600671
[14] Zaroog, O. S., Borhana, A. A., & Perumal, S. S. (2019). Biomaterials for bone replacements: past and present. In Reference Module in Materials Science and Materials Engineering. Elsevier. https://doi.org/10.1016/B978-0-12-803581-8.11442-0
[15] Hassanajili, S., Karami-Pour, A., Oryan, A., & Talaei-Khozani, T. (2019). Preparation and characterization of PLA/PCL/HA composite scaffolds using indirect 3D printing for bone tissue engineering. Materials Science and Engineering: C, 104, 109960. https://doi.org/10.1016/j.msec.2019.109960
[16] Hutmacher, D. W. (2001). Scaffold design and fabrication technologies for engineering tissues—state of the art and future perspectives. Journal of Biomaterials Science, Polymer Edition, 12(1), 107-124. https://doi.org/10.1163/156856201744489
[17] Sola, A., Bertacchini, J., D'Avella, D., Anselmi, L., Maraldi, T., Marmiroli, S., & Messori, M. (2019). Development of solvent-casting particulate leaching (SCPL) polymer scaffolds as improved three-dimensional supports to mimic the bone marrow niche. Materials Science and Engineering: C, 96, 153-165. https://doi.org/10.1016/j.msec.2018.10.086
[18] Xu, T., Yao, Q., Miszuk, J. M., Sanyour, H. J., Hong, Z., Sun, H., & Fong, H. (2018). Tailoring weight ratio of PCL/PLA in electrospun three-dimensional nanofibrous scaffolds and the effect on osteogenic differentiation of stem cells. Colloids and Surfaces B: Biointerfaces, 171, 31-39. https://doi.org/10.1016/j.colsurfb.2018.07.004
[19] Peiravi, M., & Sherafat, Z. (2024). Morphology and mechanical properties of 3D printed PCL-PLA-ZnO nanocomposite scaffolds for bone regeneration. Journal of Ultrafine Grained and Nanostructured Materials, 57(1), 28-34. https://doi.org/10.22059/jufgnsm.2024.01.04
[20] Meng, M., Le, H. R., Rizvi, M. J., & Grove, S. M. (2015). The effects of unequal compressive/tensile moduli of composites. Composite Structures, 126, 207-215. https://doi.org/10.1016/j.compstruct.2015.02.064
[21] Brydone, A. S., Meek, D., & Maclaine, S. (2010). Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224(12), 1329-1343. https://doi.org/10.1243/09544119JEIM770 | ||
|
آمار تعداد مشاهده مقاله: 191 تعداد دریافت فایل اصل مقاله: 185 |
||