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The effects of advanced age on electrocardiographic parameters, lipid profile and redox balance in male rats: role of long-term cinnamon consumption | ||
| Iranian Journal of Veterinary Research | ||
| دوره 25، شماره 2 - شماره پیاپی 87، 2024، صفحه 107-116 اصل مقاله (742.2 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2024.47879.6948 | ||
| نویسندگان | ||
| M. Salari1؛ S. Nakhaee2؛ Z. Ataie3؛ K. Farrokhfall* 4 | ||
| 1MD, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran | ||
| 2Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran | ||
| 3MD, Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran | ||
| 4Cardiovascular Diseases Research Center, College of Medicine, Birjand University of Medical Sciences, Birjand, Iran | ||
| چکیده | ||
| Background: Oxidative stress damages biological molecules and plays a role in aging-related cardiovascular diseases. Cinnamomum zeylanicum is a major source of antioxidants that may work against age-related cardiovascular changes. Aims: This study aimed to assess the changes in electrocardiography and lipid profile as well as indicators of the oxidant-antioxidant system with advanced age in rats. Also, the possible beneficial effect of cinnamon on these parameters has been investigated. Methods: In this experimental study, thirty male Sprague-Dawley rats were randomly assigned to five groups. The control groups of 12, and 20 months received a normal chow diet, while the investigation group was given a control diet mixed with cinnamon powder (1% of the diet). Also, a control group of 3-month-old rats was considered for assessment of age effects. Systolic blood pressure (SBP), ECG, serum lipid profiles, and heart oxidative stress markers were compared in different groups at the end of the study. Results: Systolic BP, serum cholesterol, HDL and LDL-cholesterol, the heart level of malondialdehyde (MDA) and nitric oxide metabolites (NOx), the ECG parameters including QRS duration, PR, Tpeak-Tend, and QT interval, as well as QTc increased significantly in older rats (20 months vs 3 months). Cinnamon consumption restored MDA levels, QRS duration, and Tpeak-Tend interval in aging hearts. Whereas, neither aging nor cinnamon consumption could affect SOD activity. Conclusion: The results demonstrated that aging is associated with ECG alteration, oxidative stress, and an increase in TC, LDL, and HDL cholesterol. Cinnamon improved electrical heart activity in aged rats (20 months) by restoration of QRS duration and Tpeak-Tend interval as well as amelioration of heart oxidative stress. Altogether, cinnamon supplementation has a cardioprotective effects during aging in rats. | ||
| کلیدواژهها | ||
| Aging؛ Cinnamomum zeylanicum؛ Electrocardiography؛ Heart؛ Oxidative stress | ||
| مراجع | ||
|
Aguilar-Alonso, P; Vera-López, O; Brambila-Colombres, E; Segura-Badilla, O; Avalos-López, R; Lazcano-Hernández, M and Navarro-Cruz, AR (2018). Evaluation of oxidative stress in cardiomyocytes during the aging process in rats treated with resveratrol. Oxid. Med. Cell. Longev., 2018: 1390483.
Andoh, T; Lee, SY and Chiueh, CC (2000). Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress. FASEB. J., 14: 2144-2146.
Antzelevitch, C and Di Diego, JM (2019). Reply to the Editor — Tpeak-Tend is alive and well. Heart Rhythm., 16: e49-e50.
Arifin, WN and Zahiruddin, WM (2017). Sample size calculation in animal studies using resource equation approach. Malays. J. Med. Sci., 24: 101-105.
Ataie, Z; Mehrani, H; Ghasemi, A and Farrokhfall, K (2019). Cinnamaldehyde has beneficial effects against oxidative stress and nitric oxide metabolites in the brain of aged rats fed with long-term, high-fat diet. J. Funct. Foods., 52: 545-551.
Badalzadeh, R; Shaghaghi, M; Mohammadi, M; Dehghan, G and Mohammadi, Z (2014). The effect of cinnamon extract and long-term aerobic training on heart function, biochemical alterations and lipid profile following exhaustive exercise in male rats. Adv. Pharm. Bull., (Suppl. 2), 4: 515-520.
Barouch, LA; Harrison, RW; Skaf, MW; Rosas, GO; Cappola, TP; Kobeissi, ZA; Hobai, IA; Lemmon, CA; Burnett, AL and O’Rourke, B (2002). Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature. 416: 337-339.
Bhupathiraju, SN and Tucker, KL (2011). Coronary heart disease prevention: nutrients, foods, and dietary patterns. Clin. Chim. Acta., 412: 1493-1514.
Chadda, KR; Ajijola, OA; Vaseghi, M; Shivkumar, K; Huang, CL and Jeevaratnam, K (2018). Ageing, the autonomic nervous system and arrhythmia: From brain to heart. Ageing Res. Rev., 48: 40-50.
Collaborators, GA (2022). Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. BMJ., 376: e068208.
El-Sawalhi, MM; Darwish, HA; Mausouf, MN and Shaheen, AA (2013). Modulation of age-related changes in oxidative stress markers and energy status in the rat heart and hippocampus: a significant role for ozone therapy. Cell. Biochem. Funct., 31: 518-525.
Gälman, C; Matasconi, M; Persson, L; Parini, P; Angelin, B and Rudling, M (2007). Age-induced hyper-cholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol. Am. J. Physiol. Endocrinol. Metab., 293: E737-742.
Grinin, L; Grinin, A and Korotayev, A (2023). Global aging: An integral problem of the future. How to turn a problem into a development driver?. In: Sadovnichy, V; Akaev, A; Ilyin, I; Malkov, S; Grinin, L; Korotayev, A (Eds.), Reconsidering the limits to growth. World-Systems evolution and global futures. (1st Edn.), Springer, Cham., https://doi.org/10.1007/978-3-031-34999-7_7. PP: 117-135.
Guo, Y; Lu, M; Qian, J and Cheng, YL (2009). Alagebrium chloride protects the heart against oxidative stress in aging rats. J. Gerontol. A Biol. Sci. Med. Sci., 64A: 629-635.
Harada, M; Hirayama, Y and Yamazaki, R (1982). Pharmacological studies on Chinese cinnamon. V. Catecholamine releasing effect of cinnamaldehyde in dogs. J. Pharmacobiodyn., 5: 539-546.
Izzo, C; Vitillo, P; Di Pietro, P; Visco, V; Strianese, A; Virtuoso, N; Ciccarelli, M; Galasso, G; Carrizzo, A and Vecchione, C (2021). The role of oxidative stress in cardiovascular aging and cardiovascular diseases. Life. 11: 60.
Khan, A; Safdar, M; Ali Khan, MM; Khattak, KN and Anderson, RA (2003). Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 26: 3215-3218.
Kim, YM; Bombeck, CA and Billiar, TR (1999). Nitric oxide as a bifunctional regulator of apoptosis. Circ. Res., 84: 253-256.
Kmecova, J and Klimas, J (2010). Heart rate correction of the QT duration in rats. Eur. J. Pharmacol., 641: 187-192.
Kumar, P; Kusumoto, FM and Goldschlager, N (2012). Bradyarrhythmias in the elderly. Clin. Geriatr. Med., 28: 703-715.
Lee, JS; Jeon, SM; Park, EM; Huh, TL; Kwon, OS; Lee, MK and Choi, MS (2003). Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J. Med. Food., 6: 183-191.
Li, J; Liu, T; Wang, L; Guo, X; Xu, T; Wu, L; Qin, L and Sun, W (2012). Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice. J. Tradit. Chin. Med., 32: 446-452.
Lorenz, JN (2002). A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol., 282: R1565-1582.
Lu, L; Xiong, Y; Zhou, J; Wang, G; Mi, B and Liu, G (2022). The therapeutic roles of cinnamaldehyde against cardiovascular diseases. Oxid. Med. Cell. Longev., 2022: 9177108.
Macfarlane, PW (2018). The influence of age and sex on the electrocardiogram. Adv. Exp. Med. Biol., 1065: 93-106.
Marques, GL; Neto, FF; de Oliveira Ribeiro, CA; Liebel, S; de Fraga, R and Bueno, RD (2015). Oxidative damage in the aging heart: An experimental rat model. Open. Cardiovasc. Med. J., 9: 78-82.
Martín-Fernández, B and Gredilla, R (2016). Mitochondria and oxidative stress in heart aging. GeroScience. 38: 225-238.
Maruthamuthu, R and Ramanathan, K (2016). Phytochemical analysis of bark extract of cinnamomum verum: a medicinal herb used for the treatment of coronary heart disease in malayali tribes, Pachamalai Hills, Tamil Nadu, India. Int. J. Pharmacogn. Phytochem. Res., 8: 1218-1222.
Nakhaee, S; Dastjerdi, M; Roumi, H; Mehrpour, O and Farrokhfall, K (2021). N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test. BMC. Pharmacol. Toxicol., 22: 1-7.
Oknińska, M; Paterek, A; Bierła, J; Czarnowska, E; Mączewski, M and Mackiewicz, U (2021). Effect of age and sex on the incidence of ventricular arrhythmia in a rat model of acute ischemia. Biomed. Pharmacother., 142: 111983. https://doi.org/10.1016/j.biopha.2021.111983.
Pagan, LU; Gomes, MJ; Gatto, M; Mota, GA; Okoshi, K and Okoshi, MP (2022). The role of oxidative stress in the aging heart. Antioxidants. 11: 336. https://doi.org/10.3390/ antiox11020336.
Parini, P; Angelin, B and Rudling, M (1999). Cholesterol and lipoprotein metabolism in aging: reversal of hyper-cholesterolemia by growth hormone treatment in old rats. Arterioscler. Thromb. Vasc. Biol., 19: 832-839.
Pender, DN; Crawford, PF; Clark, JM; Crawford, AJ; Prats, AA and Shah, SA (2018). Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial. Complement. Ther. Med., 41: 302-305.
Piantoni, C; Carnevali, L; Molla, D; Barbuti, A; DiFrancesco, D; Bucchi, A and Baruscotti, M (2021). Age-Related changes in cardiac autonomic modulation and heart rate variability in mice. Front. Neurosci., 15: 617698. https://doi.org/10.3389/fnins.2021.617698.
Reagan-Shaw, S; Nihal, M and Ahmad, N (2008). Dose translation from animal to human studies revisited. FASEB. J., 22: 659-661.
Revnic, C; Revnic, F and Voinea, S (2019). Cholesterol receptors behavior in aging male rat aorta. The effect of serum factors from patients with lipid metabolic disorders. Atherosclerosis. 287: e259-e260.
Sato, D; Xie, LH; Sovari, AA; Tran, DX; Morita, N; Xie, F; Karagueuzian, H; Garfinkel, A; Weiss, JN and Qu, Z (2009). Synchronization of chaotic early after-depolarizations in the genesis of cardiac arrhythmias. Proc. Natl. Acad. Sci., 106: 2983-2988.
Sedighi, M; Nazari, A; Faghihi, M; Rafieian-Kopaei, M; Karimi, A; Moghimian, M; Mozaffarpur, SA; Rashidipour, M; Namdari, M and Cheraghi, M (2018). Protective effects of cinnamon bark extract against ischemia-reperfusion injury and arrhythmias in rat. Phytother. Res., 32: 1983-1991.
Soerensen, M; Christensen, K; Stevnsner, T and Christiansen, L (2009). The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Mech. Ageing Dev., 130: 308-314.
Spadaccio, C; Rainer, A; Mozetic, P; Trombetta, M; Dion, RA; Barbato, R; Nappi, F and Chello, M (2015). The role of extracellular matrix in age-related conduction disorders: a forgotten player? J. Geriatr. Cardiol., 12: 76-82.
Spasojević Kosić, L; Trailović, DR and Krstić, N (2017). Age-dependent electrocardiographic and echocardiographic changes in German Shepherd dogs. Iran. J. Vet. Res., 18: 43-48.
Spindler, SR; Mote, PL; Flegal, JM and Teter, B (2013). Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice. Rejuvenation Res., 16: 143-151.
Suh, JH; Shigeno, ET; Morrow, JD; Cox, B; Rocha, AE; Frei, B and Hagen, TM (2001). Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB. J., 15: 700-706.
Triposkiadis, F; Xanthopoulos, A and Butler, J (2019). Cardiovascular aging and heart failure: JACC review topic of the week. J. Am. Coll. Cardiol., 74: 804-813.
Tse, G; Gong, M; Wong, WT; Georgopoulos, S; Letsas, KP; Vassiliou, VS; Chan, YS; Yan, BP; Wong, SH and Wu, WK (2017). The Tpeak-Tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: A systematic review and meta- analysis. Heart Rhythm., 14: 1131-1137. Wu, J; Xia, S; Kalionis, B; Wan, W and Sun, T (2014). The role of oxidative stress and inflammation in cardiovascular aging. Biomed. Res. Int., 2014: 615312. http://dx.doi.org/ 10.1155/2014/615312.
Xue, T; Xue, Y; Fang, Y; Lu, C; Fu, Y; Lai, Z; Qin, X; Huang, F; Zeng, Z and Huang, J (2023). Exploring myocardial ischemia-reperfusion injury mechanism of cinnamon by network pharmacology, molecular docking, and experiment validation. Comput. Math. Methods Med., 2023: 1066057. https://doi.org/10.1155/2023/1066057.
Zieman, SJ; Gerstenblith, G; Lakatta, EG; Rosas, GO; Vandegaer, K; Ricker, KM and Hare, JM (2001). Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to L-arginine. Circ. Res., 88: 97-102. | ||
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