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Abdalla, Menas, Hamdan, Hamdan. (1403). IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study. , 14(1), 27-30. doi: 10.22099/mbrc.2024.50865.2017
Menas A. Abdalla; Hamdan Z. Hamdan. "IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study". , 14, 1, 1403, 27-30. doi: 10.22099/mbrc.2024.50865.2017
Abdalla, Menas, Hamdan, Hamdan. (1403). 'IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study', , 14(1), pp. 27-30. doi: 10.22099/mbrc.2024.50865.2017
Abdalla, Menas, Hamdan, Hamdan. IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study. , 1403; 14(1): 27-30. doi: 10.22099/mbrc.2024.50865.2017

IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study

Molecular Biology Research Communications
دوره 14، شماره 1، 2025، صفحه 27-30    اصل مقاله (188.62 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.50865.2017
نویسندگان
Menas A. Abdalla1؛ Hamdan Z. Hamdan* 2
1Department of Pharmacology, Faculty of Pharmacy, Al-Neelain University, Khartoum, Sudan
2Department of Pathology, College of Medicine, Qassim University, Saudi Arabia
چکیده
Genetic polymorphisms in interleukin-13 (IL13) gene have been associated with asthma susceptibility in different ethnicities. We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients. A case-control study was conducted at Al-Shaab Teaching Hospital between April and October 2022. Involving fifty asthmatic patients and fifty controls. The genotypes were determined using an allele-specific polymerase chain reaction. For rs1800925, a significant association with asthma in multivariate analysis (aOR=3.15, 95% CI: 1.13–8.76; p=0.028). The T allele was the most frequent in cases and showed a significant association with asthma (aOR=1.99, 95% CI: 1.13–3.5; p=0.016). The rs20541 did not show any association with asthma. The rs1800925 is associated with an increased risk of asthma in Sudanese patients.
کلیدواژه‌ها
Bronchial asthma؛ Gene mutation؛ Genetic variation؛ IL-13
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