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Validi, Shamimeh, Saadat, Iraj. (1403). Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study. , 13(4), 247-252. doi: 10.22099/mbrc.2024.49125.1989
Shamimeh Validi; Iraj Saadat. "Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study". , 13, 4, 1403, 247-252. doi: 10.22099/mbrc.2024.49125.1989
Validi, Shamimeh, Saadat, Iraj. (1403). 'Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study', , 13(4), pp. 247-252. doi: 10.22099/mbrc.2024.49125.1989
Validi, Shamimeh, Saadat, Iraj. Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study. , 1403; 13(4): 247-252. doi: 10.22099/mbrc.2024.49125.1989

Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study

Molecular Biology Research Communications
دوره 13، شماره 4، 2024، صفحه 247-252    اصل مقاله (212.71 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.49125.1989
نویسندگان
Shamimeh Validi؛ Iraj Saadat*
Department of Biology, Faculty of Science, Shiraz University, Shiraz, Iran
چکیده
Gastric cancer is one of the most prevalent malignancies in the world. Various factors play a role in the development of this disease as risk factors. One of these genes is the FOXP3, which is located on the short arm of the X chromosome (Xp11.23). The rs3761548 polymorphism in the promoter region of this gene increases cell proliferation. In the current study, the association between this genetic polymorphism and the risk of gastric cancer was investigated. This study included 147 patients (55 women, 92 men) with gastric cancer and 147 healthy individuals (53 women, 94 men). The PCR-RFLP method is used for genotyping. Statistical analysis showed that there was no significant association between this polymorphism and the risk of gastric cancer. However, the analysis of genotype, family history and smoking risk factors simultane-oussly revealed a significant relationship between simultaneous occurrence of two (OR=3.79, 95% CI=1.77-8.09, p=0.001) and three risk factors (OR=6.44, 95% CI=1.76-23.5, p=0.017) and the risk of gastric cancer.
کلیدواژه‌ها
FOXP3؛ Gastric Cancer؛ Genetic Polymorphisms؛ PCR-RFLP
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