اخبار و اعلانات

 آمار

تعداد نشریات24
تعداد شماره‌ها877
تعداد مقالات7,848
تعداد مشاهده مقاله14,537,422
تعداد دریافت فایل اصل مقاله12,272,581
Validi, Shamimeh, Saadat, Iraj. (1403). Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study. , 13(4), 247-252. doi: 10.22099/mbrc.2024.49125.1989
Shamimeh Validi; Iraj Saadat. "Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study". , 13, 4, 1403, 247-252. doi: 10.22099/mbrc.2024.49125.1989
Validi, Shamimeh, Saadat, Iraj. (1403). 'Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study', , 13(4), pp. 247-252. doi: 10.22099/mbrc.2024.49125.1989
Validi, Shamimeh, Saadat, Iraj. Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study. , 1403; 13(4): 247-252. doi: 10.22099/mbrc.2024.49125.1989

Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study

Molecular Biology Research Communications
دوره 13، شماره 4، 2024، صفحه 247-252    اصل مقاله (212.71 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.49125.1989
نویسندگان
Shamimeh Validi؛ Iraj Saadat*
Department of Biology, Faculty of Science, Shiraz University, Shiraz, Iran
چکیده
Gastric cancer is one of the most prevalent malignancies in the world. Various factors play a role in the development of this disease as risk factors. One of these genes is the FOXP3, which is located on the short arm of the X chromosome (Xp11.23). The rs3761548 polymorphism in the promoter region of this gene increases cell proliferation. In the current study, the association between this genetic polymorphism and the risk of gastric cancer was investigated. This study included 147 patients (55 women, 92 men) with gastric cancer and 147 healthy individuals (53 women, 94 men). The PCR-RFLP method is used for genotyping. Statistical analysis showed that there was no significant association between this polymorphism and the risk of gastric cancer. However, the analysis of genotype, family history and smoking risk factors simultane-oussly revealed a significant relationship between simultaneous occurrence of two (OR=3.79, 95% CI=1.77-8.09, p=0.001) and three risk factors (OR=6.44, 95% CI=1.76-23.5, p=0.017) and the risk of gastric cancer.
کلیدواژه‌ها
FOXP3؛ Gastric Cancer؛ Genetic Polymorphisms؛ PCR-RFLP
مراجع
  1. Lu B, Li M. Helicobacter pylori eradication for preventing gastric cancer. World J Gastroenterol 2014;20:5660-5665.
  2. Eusebi LH, Telese A, Marasco G, Bazzoli F, Zagari RM. Gastric cancer prevention strategies: A global perspective. J Gastroenterol Hepatol 2020;35:1495-1502.
  3. González CA, Sala N, Capellá G. Genetic susceptibility and gastric cancer risk. Int J Cancer 2002;100:249-260.
  4. Yasui W, Oue N, Phyu PA, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: A review. Gastric Cancer 2005;8:86-94.
  5. De Reuver PR, Mehta S, Gill P, Andrici J, D’Urso L, Clarkson A, Mittal A, Hugh TJ, Samra JS, Gill AJ. Immunoregulatory forkhead box protein p3-positive lymphocytes are associated with overall survival in patients with pancreatic neuroendocrine tumors. J Am Coll Surg 2016;222:281-287.
  6. Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006;108:1571-1579.
  7. Merkenschlager M, Von Boehmer H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J ExpMed 2010 207;1347-1350.
  8. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. J Immunol 2017:198:986-992.
  9. Ohkura N, Hamaguchi M, Sakaguchi S. FOXP3 + regulatory T cells: control of FOXP3 expression by pharmacological agents. Trends Pharmacol Sci 2011;32:158-166.
  10. Oda JM, Hirata BK, Guembarovski RL, Watanabe MA. Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases. J Genet 2013;92:163-171.
  11. Nishikawa H, Koyama S. Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies. J Immunother Cancer 2021; 9:e002591.
  12. Hou J, Yu Z, Xiang R, Li C, Wang L, Chen S, Li Q, Chen M, Wang L. Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer. Exp Mol Pathol 2014;96:284-291.
  13. Hossain DMS, Panda AK, Manna A, Mohanty S, Bhattacharjee P, Bhattacharyya S, Saha T, Chakraborty S, Kar RK, Das T, Chatterjee S, Sa G. FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells. Immunity 2013;39:1057-1069.
  14. Kwon TK, Chung EJ, Lee N, Roh EY, Song EY. Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. J Otolaryngol Head Neck Surg 2017;46:21.
  15. Banin Hirata BK, Losi Guembarovski R, Vitiello GAF, Guembarovski AL, Brajaõ De Oliveira K, Watanabe MAE. FOXP3 allelic variants and haplotype structures are associated with aggressive breast cancer subtypes. Dis Markers 2017;2017:6359603.
  16. Jafarzadeh A, Jamali M, Mahdavi R, Ebrahimi HA, Hajghani H, Khosravimashizi A, Nemati M, Najafipour H, Sheikhi A, Mohammadi MM, Daneshvar H. Circulating levels of interleukin-35 in patients with multiple sclerosis: Evaluation of the influences of FOXP3 gene polymorphism and treatment program. J Mol Neurosci 2015;55:891-897.
  17. Song P, Wang XW, Li HX, Li K, Liu L, Wei C, Jian Z, Yi XL, Li Q, Wang G, Li CY, Gao TW. Association between FOXP3 polymorphisms and vitiligo in a Han Chinese population. Br J Dermatol 2013;169:571-578.
  18. Ezzeddini R, Somi MH, Taghikhani M, Moaddab SY, Masnadi Shirazi K, Shirmohammadi M, Eftekharsadat AT, Sadighi Moghaddam B, Salek Farrokhi A. Association of FOXP3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients. Cytokine 2021;138:155351.
  19. Rafiee L, Saadat I, Saadat M. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. Mol Biol Rep 2010;37:155-158.
  20. Newton CR. Mutational analysis: Known mutations: McPherson MJ, Hames D,Taylor GR (Eds). PCR2. A Practical Approach. IRL Press Oxford 1995;219-222.
  21. Saadat M. The importance of examining the Hardy-Weinberg Equilibrium in genetic association studies. Mol Biol Res Commun 2024;13:1-2.
  22. Saadat M. Evaluation of Hardy-Weinberg equilibrium in genetic association studies. Int J Immunogenet 2024;51:183-186.
  23. Saadat M. How to estimate allele frequencies and make statistical comparisons in case-control studies of polymorphic X-linked loci. Turk J Ophthalmol 2024;54:246-247
  24. Ma GF, Chen SY, Sun ZR, Miao Q, Liu YM, Zeng XQ, Luo TC, Ma LL, Lian JJ, Song DL. FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signaling pathway. Biochem Biophys Res Commun 2013;430:804-809.
  25. Ebrahimpour S, Saadat I. Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer. Mol Biol Res Commun 2014;3:223-229.
آمار
تعداد مشاهده مقاله: 821
تعداد دریافت فایل اصل مقاله: 512


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب