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Evaluation of the therapeutic potential of infrapatellar fat pad adipose-derived stem cells and their secretome for regenerating knee articular cartilage in a rat model of osteoarthritis | ||
| Iranian Journal of Veterinary Research | ||
| دوره 25، شماره 1 - شماره پیاپی 86، 2024، صفحه 33-40 اصل مقاله (585 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2024.47870.6959 | ||
| نویسندگان | ||
| S. A. Dalir1؛ A. Meimandi Parizi* 2؛ N. Tanideh* 3، 4؛ M. Kian5، 6؛ F. Nowzari1؛ A. Iraji4؛ P. Ghaemmagham7؛ N. Azarpira4، 8؛ Sh. Zare4 | ||
| 1Ph.D. Student in Veterinary Surgery, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 2Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 3Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Ph.D. Student in Comparative Biomedical Sciences, Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Student Research Committee, Shiraz | ||
| 7Department of Biostatistics, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Mesenchymal stem cell (MSC) therapy has ameliorative effects for treating knee osteoarthritis (KOA) disease. Moreover, there is a growing interest in using MSCs-derived secretome (Sec) containing trophic factors secreted by MSCs for KOA treatment. Recently, some studies have suggested that the combination of MSCs and Sec has the potential to treat the diseases. Aims: This study aimed to evaluate the ameliorative effects of combined administration of infrapatellar fat pad (IPFP)-derived MSCs, a type of adipose-derived stem cells (ASCs), for treating degenerated cartilage in a rat model of KOA. Methods: IPFP-ASCs were isolated from the IPFP of male rats. Sec was obtained from IPFP-ASCs in the fourth passage. Eight weeks after the induction of KOA by collagenase II, the rats were divided into 5 groups (n=5), including a control group with no treatment, and four experimental groups that received sodium hyaluronate (Hyalgan®, Hya), ASCs, Sec, and IPFP-ASCs+Sec, respectively by an infrapatellar injection. To perform the pathological and radiological evaluations, the animals were sacrificed 8 weeks later. Results: Our findings indicated that combined administration of the IPFP-ASCs and Sec statistically (P<0.05) improved scores of medial tibial and femoral condyles and medial fabella osteophytes. Also, it statistically (P<0.05) enhances the cartilage surface, matrix, cell distribution and population viability, and subchondral bone indices. No statistical difference was observed between IPFP-ASCs+Sec and IPFP-ASCs. Conclusion: Administration of IPFP-ASCs+Sec has a therapeutic potential to treat KOA in rats. However, there is no difference in the combined administration of IPFP-ASCs and Sec with IPFP-ASCs alone. | ||
| کلیدواژهها | ||
| Adipose-derived stem cells؛ Articular cartilage؛ Infrapatellar fat pad؛ Osteoarthritis؛ Secretome | ||
| مراجع | ||
|
Abd-Elsayed, A (2018). Stem cells for the treatment of knee osteoarthritis: a comprehensive review. Pain Physician. 21: 229-241.
Bahmanpour, S; Talaei Khozani, T and Rezaei Tazangi, F (2019). Evaluation of the capability of the Wharton’s jelly mesenchymal stem cell aggregates to express the markers of three germ cell lineages. Arch. Iran. Med., 22: 85-90.
Chen, D; Shen, J; Zhao, W; Wang, T; Han, L; Hamilton, JL and Im, HJ (2017). Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res., 5: 1-13.
Cui, A; Li, H; Wang, D; Zhong, J; Chen, Y and Lu, H (2020). Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. E Clinical Medicine. 30: 1-13.
D’arrigo, D; Roffi, A; Cucchiarini, M; Moretti, M; Candrian, C and Filardo, G (2019). Secretome and extracellular vesicles as new biological therapies for knee osteoarthritis: a systematic review. J. Clin. Med., 8: 1-16.
Ding, DC; Wu, KC; Chou, HL; Hung, WT; Liu, HW and Chu, TY (2015). Human infrapatellar fat pad-derived stromal cells have more potent differentiation capacity than other mesenchymal cells and can be enhanced by hyaluronan. Cell Transplant. 24: 1221-1232.
Doyle, LM and Wang, MZ (2019). Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells. 8: 727-750.
Eleuteri, S and Fierabracci, A (2019). Insights into the secretome of mesenchymal stem cells and its potential applications. Int. J. Mol. Sci., 20: 1-22.
English, A; Jones, E; Corscadden, D; Henshaw, K; Chapman, T; Emery, P and Mcgonagle, D (2007). A comparative assessment of cartilage and joint fat pad as a potential source of cells for autologous therapy development in knee osteoarthritis. Rheumatology. 46: 1676-1683.
Ferreira, JR; Teixeira, GQ; Santos, SG; Barbosa, MA; Almeida-Porada, G and Gonçalves, RM (2018). Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning. Front Immunol., 9: 1-17.
Fraser, JK; Wulur, I; Alfonso, Z and Hedrick, MH (2006). Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol., 24: 150-154.
Fujii, S; Endo, K; Matsuta, S; Komori, K and Sekiya, I (2022). Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads. Regen Ther., 21: 611-619.
Garcia, J; Wright, K; Roberts, S; Kuiper, JH; Mangham, C; Richardson, J and Mennan, C (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Sci. Rep., 6: 1-11.
Grassel, S and Muschter, D (2020). Recent advances in the treatment of osteoarthritis. F1000Res. 9: 1-17.
Harrell, CR; Fellabaum, C; Jovicic, N; Djonov, V; Arsenijevic, N and Volarevic, V (2019). Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome. Cells. 8: 1-34.
Haubruck, P; Heller, R; Blaker, CL; Clarke, EC; Smith, SM; Burkhardt, D; Liu, Y; Stoner, S; Zaki, S and Shu, CC (2023). Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models. Osteoarthritis Cartilage. 31: 1602-1611.
Hermann, W; Lambova, S and Muller-Ladner, U (2018). Current treatment options for osteoarthritis. Curr Rheumato. Rev, 14: 108-116.
Householder, NA; Raghuram, A; Agyare, K; Thipaphay, S and Zumwalt, M (2023). A review of recent innovations in cartilage regeneration strategies for the treatment of primary osteoarthritis of the knee: Intra-articular injections. Orthop. J. Sports Med., 11: 1-20.
Huang, R; Li, W; Zhao, Y; Yang, F and Xu, M (2020). Clinical efficacy and safety of stem cell therapy for knee osteoarthritis: A meta-analysis. Medicine (Baltimore). 99: e19434.
Hunter, DJ; Schofield, D and Callander, E (2014). The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol, 10: 437-441.
Hussain, SM; Neilly, DW; Baliga, S; Patil, S and Meek, R (2016). Knee osteoarthritis: a review of management options. Scott. Med. J., 61: 7-16.
Kan, C; Chen, L; Hu, Y; Lu, H; Li, Y; Kessler, JA and Kan, L (2017). Microenvironmental factors that regulate mesenchymal stem cells: lessons learned from the study of heterotopic ossification. Histol Histopathol, 32: 1-16.
Kangari, P; Talaei-Khozani, T; Razeghian-Jahromi, I and Razmkhah, M (2020). Mesenchymal stem cells: amazing remedies for bone and cartilage defects. Stem Cell Res. Ther., 11: 1-21.
Kouroupis, D; Bowles, AC; Willman, MA; Perucca Orfei, C; Colombini, A; Best, TM; Kaplan, LD and Correa, D (2019). Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation. Sci. Rep., 9: Hi1-16.
Kouroupis, D; Kaplan, LD and Best, TM (2022). Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures. Sci. Rep., 12: 1-15.
Kurniawan, A; Ivansyah, MD; Dilogo, IH and Hutami, WD (2023). Umbilical cord mesenchymal stem cells combined with secretome for treating congenital pseudarthrosis of the Tibia: a case series. Eur J Orthop Surg. Traumatol., 33: 2881-2888.
Liao, HJ; Chang, CH; Huang, CF and Chen, HT (2022). Potential of using infrapatellar-fat-pad-derived mesenchymal stem cells for therapy in degenerative arthritis: Chondrogenesis, exosomes, and transcription regulation. Biomolecules. 12: 386-397.
Loo, SJQ and Wong, NK (2021). Advantages and challenges of stem cell therapy for osteoarthritis (Review). Biomed. Rep., 15: 67-78.
Mainil-Varlet, P; Aigner, T; Brittberg, M; Bullough, P; Hollander, A; Hunziker, E; Kandel, R; Nehrer, S; Pritzker, K; Roberts, S; Stauffer, E and International Cartilage Repair, S (2003). Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J. Bone Jt. Surg., 85: 45-57.
Nabavizadeh, SS; Talaei-Khozani, T; Zarei, M; Zare, S; Hosseinabadi, OK; Tanideh, N and Daneshi, S (2022). Attenuation of osteoarthritis progression through intra-articular injection of a combination of synovial membrane-derived MSCs (SMMSCs), platelet-rich plasma (PRP) and conditioned medium (secretome). J. Orthop. Surg. Res., 17: 1-12.
Nowzari, F; Zare, M; Tanideh, N; Meimandi-Parizi, A; Kavousi, S; Saneian, SM; Zare, S; Koohi-Hosseinabadi, O; Ghaemmaghami, P; Dehghanian, A; Daneshi, S; Azarpira, N; Aliabadi, A; Samimi, K; Irajie, C and Iraji, A (2023). Comparing the healing properties of intra-articular injection of human dental pulp stem cells and cell-free-secretome on induced knee osteoarthritis in male rats. Tissue Cell. 82: 1-15.
Oh, SJ; Choi, KU; Choi, SW; Kim, SD; Kong, SK; Lee, S and Cho, KSJSCI (2020). Comparative analysis of adipose-derived stromal cells and their secretome for auricular cartilage regeneration. Stem. Cells. Int., 2: 1-8.
Primorac, D; Molnar, V; Rod, E; Jeleč, Ž; Čukelj, F; Matišić, V; Vrdoljak, T; Hudetz, D; Hajsok, H and Borić, I (2020). Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations. Genes. 11: 854-892.
Ragni, E; Colombini, A; Vigano, M; Libonati, F; Perucca Orfei, C; Zagra, L and De Girolamo, L (2021). Cartilage protective and immunomodulatory features of osteoarthritis synovial fluid-treated adipose-derived mesenchymal stem cells secreted factors and extracellular vesicles-embedded miRNAs. Cells. 10: 1072-1084.
Rezuş, E; Burlui, A; Cardoneanu, A; Macovei, LA; Tamba, BI and Rezuş, C (2021). From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int. J. Mol. Sci., 22: 2697-2720.
Shariatzadeh, M; Song, J and Wilson, SL (2019). The efficacy of different sources of mesenchymal stem cells for the treatment of knee osteoarthritis. Cell Tissue Res., 378: 399-410.
Soetjahjo, B and Utomo, DN (2022). Mesenchymal stem cells secretome and osteoarthritis: A state of the art. Hip Knee J., 3: 56-63.
Sun, Y; Chen, S and Pei, M (2018). Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine. Rheumatology (Oxford). 57: 2072- 2086. Sun, C; Zhang, X; Lee, WG; Tu, Y; Li, H; Cai, X and Yang, H (2020). Infrapatellar fat pad resection or preservation during total knee arthroplasty: a meta-analysis of randomized controlled trials. J. Orthop. Surg. Res., 15: 297-305.
Tanideh, N; Nabavizadeh, SS; Ashkani-Esfahani, S; Hosseinabadi, OK; Ghaemmaghami, P; Zare, S; Azarpira, N; Tanideh, R and Daneshi, S (2021). Paracrine effect of synovial-derived stem cells on induced knee osteoarthritis in rats. Shiraz E-Med. J., 22: 1-8.
Trzyna, A and Banaś-Ząbczyk, A (2021). Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”. Biomolecules. 11: 878-901.
Vahedi, P; Moghaddamshahabi, R; Webster, TJ; Calikoglu Koyuncu, AC; Ahmadian, E; Khan, WS; Jimale Mohamed, A and Eftekhari, A (2021). The use of infrapatellar fat pad-derived mesenchymal stem cells in articular cartilage regeneration: A review. Int. J. Mol. Sci., 22: 9215-9227.
Xu, Z; Chen, T; Luo, J; Ding, S; Gao, S and Zhang, J (2017). Cartilaginous metabolomic study reveals potential mechanisms of osteophyte formation in osteoarthritis. J. Proteome Res., 16: 1425-1435.
Yao, B; Samuel, LT; Acuna, AJ; Faour, M; Roth, A; Kamath, AF and Mont, MA (2021). Infrapatellar fat pad resection or preservation during total knee arthroplasty: A systematic review. J. Knee Surg., 34: 415-421.
Zare, R; Tanideh, N; Nikahval, B; Mirtalebi, MS; Ahmadi, N; Zarea, S; Hosseinabadi, OK; Bhimani, R and Ashkani-Esfahani, S (2020). Are stem cells derived from synovium and fat pad able to treat induced knee osteoarthritis in rats? Int. J. Rheumatol., 2020: 1-8.
Zhang, R; Ma, J; Han, J; Zhang, W and Ma, J (2019). Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis. Am. J. Transl. Res., 11: 6275-6289.
Zhong, YC; Wang, SC; Han, YH and Wen, Y (2020). Recent advance in source, property, differentiation, and applications of infrapatellar fat pad adipose-derived stem cells. Stem. Cells Int., 2020: 1-14.
Zhu, X; Chan, YT; Yung, PS; Tuan, RS and Jiang, Y (2021). Subchondral bone remodeling: a therapeutic target for osteoarthritis. Front Cell Dev Biol. 8: 1-19.
Zhuang, L; Hulin, JA; Gromova, A; Tran Nguyen, TD; Yu, RT; Liddle, C; Downes, M; Evans, RM; Makarenkova, HP and Meech, R (2014). Barx2 and Pax7 have antagonistic functions in regulation of Wnt signaling and satellite cell differentiation. Stem. Cells. 32: 1661-1673. | ||
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