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Maleki, Reza, Noorbakhsh, Mohammad Foad, Kazemipour, Nasrin, Masudian, Malihe, Namazi, Fatemeh, Nazifi, Saeed. (1403). The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat. , 13(4), 193-200. doi: 10.22099/mbrc.2024.49925.1964
Reza Maleki; Mohammad Foad Noorbakhsh; Nasrin Kazemipour; Malihe Masudian; Fatemeh Namazi; Saeed Nazifi. "The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat". , 13, 4, 1403, 193-200. doi: 10.22099/mbrc.2024.49925.1964
Maleki, Reza, Noorbakhsh, Mohammad Foad, Kazemipour, Nasrin, Masudian, Malihe, Namazi, Fatemeh, Nazifi, Saeed. (1403). 'The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat', , 13(4), pp. 193-200. doi: 10.22099/mbrc.2024.49925.1964
Maleki, Reza, Noorbakhsh, Mohammad Foad, Kazemipour, Nasrin, Masudian, Malihe, Namazi, Fatemeh, Nazifi, Saeed. The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat. , 1403; 13(4): 193-200. doi: 10.22099/mbrc.2024.49925.1964

The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat

Molecular Biology Research Communications
دوره 13، شماره 4، 2024، صفحه 193-200    اصل مقاله (608.69 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.49925.1964
نویسندگان
Reza Maleki1؛ Mohammad Foad Noorbakhsh1؛ Nasrin Kazemipour* 1؛ Malihe Masudian2؛ Fatemeh Namazi3؛ Saeed Nazifi4
1Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2Molecular Department of Central Laboratory, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
4Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
چکیده
Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective properties of sitagliptin against cyclophosphamide-induced hepatotoxicity. Fifty male rats were randomly divided into five groups. They were pre-treated with either sitagliptin or normal saline once a day for the first ten days of the study. To induce acute hepatotoxicity, cyclophosphamide (200 mg/kg, i.p) was injected only one time and 45 min after the last dose of sitagliptin. The rats were sacrificed on the 11th day, and their blood and liver were collected for biochemical, gene expression, and histopathological assessments. Our results showed that cyclophosphamide induced obvious liver toxicity as marked by an increase in serum levels of alanine transaminase and aspartate transaminase, reduced serum albumin and total protein levels, in addition to histopathological changes. The malondialdehyde, tumor necrosis factor-, and interleukin-6 levels were also elevated and total antioxidant capacity declined in serum and hepatic homogenates. Sitagliptin magnificently attenuated the cylophosphamide-induced histological alterations, improved liver function tests, enhanced total antioxidant capacity, and decreased malondialdehyde, tumor necrosis factor-α, and interleukin-6 in the blood and hepatic tissues. These findings suggest that sitagliptin has hepatoprotective activity against cyclophosphamide toxicity, which may be due to its antioxidant and anti-inflammatory effects.
کلیدواژه‌ها
Cyclophosphamide؛ Hepatotoxicity؛ Oxidative Stress؛ Sitagliptin
مراجع
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