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Moghtit, Fatima Zohra, Boughrara, Wefa, Dorgham, Samia, Koriche, Ilies, Ouahba, Imene, Ammour, Amina, Bekadja, Amine, Aberkane, Meriem Samia. (1403). Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia. , 13(3), 175-182. doi: 10.22099/mbrc.2024.49437.1955
Fatima Zohra Moghtit; Wefa Boughrara; Samia Dorgham; Ilies Koriche; Imene Ouahba; Amina Ammour; Amine Bekadja; Meriem Samia Aberkane. "Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia". , 13, 3, 1403, 175-182. doi: 10.22099/mbrc.2024.49437.1955
Moghtit, Fatima Zohra, Boughrara, Wefa, Dorgham, Samia, Koriche, Ilies, Ouahba, Imene, Ammour, Amina, Bekadja, Amine, Aberkane, Meriem Samia. (1403). 'Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia', , 13(3), pp. 175-182. doi: 10.22099/mbrc.2024.49437.1955
Moghtit, Fatima Zohra, Boughrara, Wefa, Dorgham, Samia, Koriche, Ilies, Ouahba, Imene, Ammour, Amina, Bekadja, Amine, Aberkane, Meriem Samia. Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia. , 1403; 13(3): 175-182. doi: 10.22099/mbrc.2024.49437.1955

Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia

Molecular Biology Research Communications
دوره 13، شماره 3، 2024، صفحه 175-182    اصل مقاله (325.65 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2024.49437.1955
نویسندگان
Fatima Zohra Moghtit* 1؛ Wefa Boughrara2، 3؛ Samia Dorgham2؛ Ilies Koriche2؛ Imene Ouahba2؛ Amina Ammour4؛ Amine Bekadja5؛ Meriem Samia Aberkane2، 6
1Department of biology, Faculty of Science and Technology, University of Ain Temouchent-Belhadj Bouchaib-, Algeria
2Service de Cytogénétique et de Biologie moléculaire de l’Etablissement Hospitalo-universitaire d’Oran (1er Novembre)
3École Supérieure en Sciences Biologiques d'Oran (ESSBO), BP 1042, Saim Mohamed 31003, Oran, Algeria
4Université des sciences et de la technologie d’Oran Mohamed Boudiaf
5Service d’hématologie et de thérapie cellulaire de l’Etablissement Hospitalo-universitaire d’Oran (1er Novembre)
6Département de pharmacie, Faculté de Médecine, Université Oran1
چکیده
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (FLT3-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of FLT3-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for FLT3-ITD mutation by using polymerase chain reaction. FLT3-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the FLT3 mutated group. This preliminary study provides first-time prevalence estimates for FLT3-ITD mutation in acute myeloid leukemia patients from the West region of Algeria. 
کلیدواژه‌ها
FLT3؛ ITD؛ Acute myeloid leukemia؛ Prevalence؛ West of Algeria
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