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Clinicopathological investigation of nutritional osteodystrophia fibrosa in a flock of young stall-fed goats | ||
| Iranian Journal of Veterinary Research | ||
| دوره 24، شماره 4 - شماره پیاپی 85، 2023، صفحه 351-356 اصل مقاله (977.9 K) | ||
| نوع مقاله: Scientific report | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2023.47971.6968 | ||
| نویسندگان | ||
| A. T. Faslu Rahman1؛ M. Sharma1؛ A. K. Mariappan2؛ S. D. Vinay Kumar1؛ D. S. Rana1؛ D. K. Pankaj3؛ N. Kumar1؛ P. M. Nair4؛ P. Thamizhan5؛ G. Saikumar2؛ V. Singh2؛ P. Kumar* 2 | ||
| 1Ph.D. Student in Veterinary Pathology, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India | ||
| 2Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India | ||
| 31Ph.D. Student in Veterinary Pathology, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India | ||
| 4Ph.D. Student in Animal Nutrition, Division of Animal Nutrition, ICAR-National Dairy Research Institute, Karnal, 132001, Haryana, India | ||
| 5Ph.D. Student in Animal Nutrition, Division of Animal Nutrition, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India | ||
| چکیده | ||
| Background: Osteodystrophia fibrosa (ODF) is a metabolic disorder affecting the skeletal system, causing progressive loss of calcified bone mass and its replacement with fibrous tissue, which may be a sequel to primary or secondary hyperparathyroidism. This report intends to document the clinicopathological findings of ODF in a flock of young goats fed primarily on a wheat bran-rich diet. Case description: In a flock of 50 stall-fed goats aged 1 to 2 years, seven were clinically presented with bilateral facial enlargement, leading to dyspnea and difficulty in prehension and mastication. Among the seven clinically affected goats, four died in 2 months. Findings/treatment and outcome: The clinical examination revealed bilateral mandibular enlargement and limb deformities. On radiography, the maxilla and mandible had decreased radiopacity. Fine needle aspiration cytology (FNAC) from the affected bones showed occasional fibroblasts and individual osteoclasts clusters. On necropsy, the enlarged mandible revealed a meaty consistency. Undecalcified histological sections of the mandible showed severe osteopenia, multiple osteoclasts, Howship’s lacunae, and extensive fibroplasia. Dietary corrective measures led to the prevention of ODF in the rest of the flock. Conclusion: Excessive wheat bran feeding in stallfed goats might have led to calcium and phosphorus imbalance, resulting in nutritional secondary hyperparathyroidism and subsequent skeletal deformities. FNAC of the affected bones, gross and histological findings provide a clinicopathological diagnosis of ODF. | ||
| کلیدواژهها | ||
| Goat؛ Osteodystrophia fibrosa؛ Secondary hyperparathyroidism | ||
| مراجع | ||
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