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Valiullina, Aigul kh., Zmievskaya, Ekaterina A., Ganeeva, Irina A., Zhuravleva, Margarita N., Garanina, Ekaterina E., Rizvanov, Albert A., Petukhov, Alexey V., Bulatov, Emil R.. (1402). Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. , 12(4), 139-148. doi: 10.22099/mbrc.2023.47125.1820
Aigul kh. Valiullina; Ekaterina A. Zmievskaya; Irina A. Ganeeva; Margarita N. Zhuravleva; Ekaterina E. Garanina; Albert A. Rizvanov; Alexey V. Petukhov; Emil R. Bulatov. "Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line". , 12, 4, 1402, 139-148. doi: 10.22099/mbrc.2023.47125.1820
Valiullina, Aigul kh., Zmievskaya, Ekaterina A., Ganeeva, Irina A., Zhuravleva, Margarita N., Garanina, Ekaterina E., Rizvanov, Albert A., Petukhov, Alexey V., Bulatov, Emil R.. (1402). 'Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line', , 12(4), pp. 139-148. doi: 10.22099/mbrc.2023.47125.1820
Valiullina, Aigul kh., Zmievskaya, Ekaterina A., Ganeeva, Irina A., Zhuravleva, Margarita N., Garanina, Ekaterina E., Rizvanov, Albert A., Petukhov, Alexey V., Bulatov, Emil R.. Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. , 1402; 12(4): 139-148. doi: 10.22099/mbrc.2023.47125.1820

Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line

Molecular Biology Research Communications
دوره 12، شماره 4، 2023، صفحه 139-148    اصل مقاله (365.56 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.47125.1820
نویسندگان
Aigul kh. Valiullina1؛ Ekaterina A. Zmievskaya1؛ Irina A. Ganeeva1؛ Margarita N. Zhuravleva1؛ Ekaterina E. Garanina1؛ Albert A. Rizvanov1؛ Alexey V. Petukhov2؛ Emil R. Bulatov* 1، 3
1Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
2Institute of Hematology, Almazov National Medical Research Center, 197341 Saint Petersburg, Russia
3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
چکیده
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2.26 million new cases of cancer in 2020.  Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of solid tumors, such as breast cancer.  In this work the effectiveness of CAR-T cells against monolayer and three-dimensional bioprinted tumor-like structures made of modified MCF-7 breast cancer cells was assessed. The cytokine profile of supernatants after co-cultivation of MCF-7 tumor cell models with CAR-T cells was also measured to reveal the inflammatory background associated with this interaction.
کلیدواژه‌ها
Breast cancer؛ MCF-7؛ CAR-T؛ Immunotherapy؛ Solid tumor
مراجع
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