اخبار و اعلانات

 آمار

تعداد نشریات24
تعداد شماره‌ها935
تعداد مقالات8,388
تعداد مشاهده مقاله16,988,551
تعداد دریافت فایل اصل مقاله14,377,094
Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. (1402). The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed. , 12(3), 109-115. doi: 10.22099/mbrc.2023.47336.1827
Serbulent Yiğit; Selim Kul; Recai Aci; Adem Keskin; Tuğçe Tuygun; Esra Duman. "The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed". , 12, 3, 1402, 109-115. doi: 10.22099/mbrc.2023.47336.1827
Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. (1402). 'The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed', , 12(3), pp. 109-115. doi: 10.22099/mbrc.2023.47336.1827
Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed. , 1402; 12(3): 109-115. doi: 10.22099/mbrc.2023.47336.1827

The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed

Molecular Biology Research Communications
دوره 12، شماره 3، 2023، صفحه 109-115    اصل مقاله (173.41 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.47336.1827
نویسندگان
Serbulent Yiğit1، 2؛ Selim Kul3؛ Recai Aci* 4؛ Adem Keskin5؛ Tuğçe Tuygun6؛ Esra Duman7
1Department of Genetics, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkiye
2Department of Medical Biology, Graduate Institute, Ondokuz Mayis University, Samsun, Turkiye
3Faculty of Veterinary Medicine, Department of Animal Breeding, Fırat University, Elazig, Turkiye
4Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkiye
5University Faculty of Medicine, Department of Biochemistry, Aydın, Turkiye
6Department of Parasitology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkiye
7Department of Gastrology and Hepatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye
چکیده
In this study, the relationship between RORA 23bp indel genotype and allele frequency with twin pregnancy, fertility, live weight and milk yield in 106 female Akkaraman ewes raised in Elazığ province was investigated. In the study conducted in Elâzığ province, 10ml milk was collected from 106 Akkaraman sheep and DNA was extracted from these milk. In RORA 23bp indel genotype frequency, DD genotype was found more than ID and II genotypes and RORA 23bp indel ın allele frequency, the D allele was found to be higher than the I allele. In both the first and second parity, the twinning rate was found to be lower.  In both the first and second parity, the twinning rate was higher in the DD genotype, and it was observed that this genotype promınated mıddle lıvestock weıght and mılk yıeld. According to the results of our study, mutations in the RORA gene, which is a gene affecting reproductive efficiency in sheep, do not have a positive effect on fertility and twinning rate in Akkaraman sheep. To sum, this study provided theoretical references for the comprehensively research of the function of RORA gene and the breeding of Akkaraman  Sheep. The 23-bp indel variants can be considered as molecular markers for litter size of sheep for marker-assisted selection breeding.
کلیدواژه‌ها
Sheep؛ RORA؛ Insertion/deletion (Indel)؛ Mmutation؛ Litter size
مراجع
  1. AKTAŞ AH, Ankarali B, Halici I, Demirci U, Atik A, Yaylaci E. Growth traits and survival rates of Akkaraman lambs in breeder flocks in Konya Province. Turkish J Vet Anim Sci 2014;38:40-45.
  2. Bayram D, Akyuz B, Arslan K, Ozdemir F, Aksel E, Çinar MU. DGAT1, CAST and IGF-I gene polymorphisms in Akkaraman lambs and their effects on live weights up to weaning age. Kafkas Univ Vet Fak Derg 2019;25:9-15.
  3. Safari E, Fogarty NM, Gilmour AR. A review of genetic parameter estimates for wool, growth, meat and reproduction traits in sheep. Livest Prod Sci 2005;92:271-289.
  4. Esmailizadeh AK. A partial genome scan to identify quantitative trait loci affecting birthweight in Kermani sheep. Small Rumin Res 2010;94:73-78.
  5. Ranjbari M, Hashemi A, Mardani K, Darvishzadeh R. Allelic polymorphism of Makoei sheep calpastatin gene identified by polymerase chain reaction and single strand conformation polymorphism. J Agric Sci Technol 2012;14:533-538.
  6. Jetten AM, Cook DN. (Inverse) Agonists of retinoic acid–related orphan receptor γ: regulation of immune responses, inflammation, and autoimmune disease. Annu Rev Pharmacol Toxicol 2020;60:371-390.
  7. Burris TP. Nuclear hormone receptors for heme: REV-ERBα and REV-ERBβ are ligand-regulated components of the mammalian clock. Mol Endocrinol 2008;22:1509-1520.
  8. Kang HS, Angers M, Beak JY, Wu X, Gimble JM, Wada T, Wada T, Xie W, Collins JB, Grissom SF, Jetten AM. Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism. Physiol Genomics 2007;31:281-294.
  9. Sarachana T, Xu M, Wu RC, Hu VW. Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One 2011;6:e17116.
  10. Lu P, Feng X, Zhou JS, Liu XB, Chen QX, Li M. Identification and analysis of a 5-bp indel of a porcine BMP7 gene promoter. Genet Mol Res 2014;13:4326-4335.
  11. Li H, Xu H, Akhatayeva Z, Liu H, Lin C, Han X, Lu X, Lan X, Zhang Q, Pan C. Novel indel variations of the sheep FecB gene and their effects on litter size. Gene 2021;767: 145176.
  12. Hui Y, Zhang Y, Wang K, Pan C, Chen H, Qu L, Song X, Lan X. Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads. Theriogenology 2020;147:108-115.
  13. Kang Z, Jiang E, Wang K, Pan C, Chen H, Yan H, Zhu H, Liu J, Qu L, Lan X. Goat membrane associated ring-CH-type finger 1 (MARCH1) mRNA expression and association with litter size. Theriogenology 2019;128:8-16.
  14. Berberoğlu S. Akkaraman ırkı koyunlarda üreme mevsimi dışında östrüsü uyarmak amacıyla kullanılan vaginal sünger uygulamalarında ilave progesteron uygulamalarının üreme performansı üzerine etkisi n.d. Acik Bilim 2020.
  15. Calus MPL, De Haas Y, Pszczola M, Veerkamp RF. Predicted accuracy of and response to genomic selection for new traits in dairy cattle. Animal 2013;7:183-191.
  16. Abdoli R, Zamani P, Mirhoseini SZ, Ghavi Hossein‐Zadeh N, Nadri S. A review on prolificacy genes in sheep. Reprod Domest Anim 2016;51:631-637.
  17. Özmen Ö, Kul S, Gök T. Elazığ ilinde halk elinde yetiştirilen akkaraman ırkı koyun ve kuzulara ait bazı verim özellikleri. Fırat Üniversitesi Sağlık Bilim Vet Derg 2015;29:81-85.
  18. Nguyen A, Rauch TA, Pfeifer GP, Hu VW. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J 2010; 24:3036-3051.
  19. Yang Y, Hu H, Mao C, Jiang F, Lu X, Han X, Hao K, Lan X, Zhang Q, Pan C. Detection of the 23-bp nucleotide sequence mutation in retinoid acid receptor related orphan receptor alpha (RORA) gene and its effect on sheep litter size. Anim Biotechnol 2022;33:70-78.
  20. Sarachana T, Hu VW. Differential recruitment of coregulators to the RORA promoter adds another layer of complexity to gene (dys) regulation by sex hormones in autism. Mol Autism 2013;4:1-17.
  21. Ozmen O, Kul S, Gok T. Determination of genetic diversity of the Akkaraman sheep breed from Turkey. Small Rumin Res 2020;182:37-45.
  22. KIRIKÇI K. Polymorphism of the calpastatin (CAST) and growth differentiation factor 9 (GDF9) genes in Akkaraman Sheep Breed. Hayvansal Üretim 2022;63:21-26.
  23. Saygili E, Ozdemir M. Determinatıon of the MSTN/HaeIII gene polymorphism in indigenous Morkaraman sheep. J Hell Vet Med Soc 2023;74:5449-5456.
آمار
تعداد مشاهده مقاله: 2,278
تعداد دریافت فایل اصل مقاله: 1,192


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب