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Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. (1402). The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed. , 12(3), 109-115. doi: 10.22099/mbrc.2023.47336.1827
Serbulent Yiğit; Selim Kul; Recai Aci; Adem Keskin; Tuğçe Tuygun; Esra Duman. "The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed". , 12, 3, 1402, 109-115. doi: 10.22099/mbrc.2023.47336.1827
Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. (1402). 'The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed', , 12(3), pp. 109-115. doi: 10.22099/mbrc.2023.47336.1827
Yiğit, Serbulent, Kul, Selim, Aci, Recai, Keskin, Adem, Tuygun, Tuğçe, Duman, Esra. The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed. , 1402; 12(3): 109-115. doi: 10.22099/mbrc.2023.47336.1827

The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed

Molecular Biology Research Communications
دوره 12، شماره 3، 2023، صفحه 109-115    اصل مقاله (173.41 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.47336.1827
نویسندگان
Serbulent Yiğit1، 2؛ Selim Kul3؛ Recai Aci* 4؛ Adem Keskin5؛ Tuğçe Tuygun6؛ Esra Duman7
1Department of Genetics, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkiye
2Department of Medical Biology, Graduate Institute, Ondokuz Mayis University, Samsun, Turkiye
3Faculty of Veterinary Medicine, Department of Animal Breeding, Fırat University, Elazig, Turkiye
4Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkiye
5University Faculty of Medicine, Department of Biochemistry, Aydın, Turkiye
6Department of Parasitology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkiye
7Department of Gastrology and Hepatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye
چکیده
In this study, the relationship between RORA 23bp indel genotype and allele frequency with twin pregnancy, fertility, live weight and milk yield in 106 female Akkaraman ewes raised in Elazığ province was investigated. In the study conducted in Elâzığ province, 10ml milk was collected from 106 Akkaraman sheep and DNA was extracted from these milk. In RORA 23bp indel genotype frequency, DD genotype was found more than ID and II genotypes and RORA 23bp indel ın allele frequency, the D allele was found to be higher than the I allele. In both the first and second parity, the twinning rate was found to be lower.  In both the first and second parity, the twinning rate was higher in the DD genotype, and it was observed that this genotype promınated mıddle lıvestock weıght and mılk yıeld. According to the results of our study, mutations in the RORA gene, which is a gene affecting reproductive efficiency in sheep, do not have a positive effect on fertility and twinning rate in Akkaraman sheep. To sum, this study provided theoretical references for the comprehensively research of the function of RORA gene and the breeding of Akkaraman  Sheep. The 23-bp indel variants can be considered as molecular markers for litter size of sheep for marker-assisted selection breeding.
کلیدواژه‌ها
Sheep؛ RORA؛ Insertion/deletion (Indel)؛ Mmutation؛ Litter size
مراجع
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