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Deocaris, Custer, Alinsug, Malona. (1402). Molecular mimicry and COVID-19: Potential implications for global fertility. , 12(2), 71-76. doi: 10.22099/mbrc.2023.47122.1819
Custer C. Deocaris; Malona V. Alinsug. "Molecular mimicry and COVID-19: Potential implications for global fertility". , 12, 2, 1402, 71-76. doi: 10.22099/mbrc.2023.47122.1819
Deocaris, Custer, Alinsug, Malona. (1402). 'Molecular mimicry and COVID-19: Potential implications for global fertility', , 12(2), pp. 71-76. doi: 10.22099/mbrc.2023.47122.1819
Deocaris, Custer, Alinsug, Malona. Molecular mimicry and COVID-19: Potential implications for global fertility. , 1402; 12(2): 71-76. doi: 10.22099/mbrc.2023.47122.1819

Molecular mimicry and COVID-19: Potential implications for global fertility

Molecular Biology Research Communications
دوره 12، شماره 2، 2023، صفحه 71-76    اصل مقاله (169.61 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.47122.1819
نویسندگان
Custer C. Deocaris* ؛ Malona V. Alinsug
Atomic Research Division, Philippine Nuclear Research Institute, Department of Science and Technology, Commonwealth Avenue, Diliman, Quezon City 1101 Philippines
چکیده
There has been a concerning increase in the incidence of autoimmune diseases following SARS-CoV-2 infection, with molecular mimicry proposed as a potential mechanism. Our study identified nine fertility-associated proteins (AMH, BMP2, CUBN, DNER, ERCC1, KASH5, MSLN, TPO, and ZP3) that exhibit potential molecular mimicry with MHC-II epitopes of SARS-CoV-2 proteins (N, ORF1A, ORF1AB, and S). We screened for epitopes based on in silico binding using DR-, DQ-, and DP-haplotypes that predispose susceptible individuals to autoimmune diseases. Our systematic analysis revealed that 41 countries with population coverage of over 50% had a pre-COVID pandemic total fertility rate of less than 2.1 births per woman. With over 761 million people from 229 countries and territories infected since December 2019, there may be a potential for a foreseeable negative effect on fertility in specific countries, particularly in high-income economies experiencing rapid demographic changes.
کلیدواژه‌ها
SARS-CoV-2؛ Autoimmune diseases؛ Molecular mimicry؛ Fertility؛ MHC-II epitopes؛ In silico binding
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مراجع
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