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An endoscopic and histopathological assessment and correlation of endoscopic score with clinical activity index (CIBDAI) in the diagnosis of canine idiopathic inflammatory bowel disease | ||
| Iranian Journal of Veterinary Research | ||
| دوره 24، شماره 1 - شماره پیاپی 82، 2023، صفحه 58-64 اصل مقاله (469.67 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2022.40974.5945 | ||
| نویسندگان | ||
| M. Sandhya Bhavani* 1؛ S. Kavitha2؛ B. Nagarajan1؛ N. Pazhanivel3؛ S. Vairamuthu4؛ A. A. Bhat5 | ||
| 1Department of Clinics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-7, Tamil Nadu, India | ||
| 2Department of Veterinary Clinical Medicine, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-7, Tamil Nadu, India | ||
| 3Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-7, Tamil Nadu, India | ||
| 4Department of Centarlised Clinical Laboratory, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-7, Tamil Nadu, India | ||
| 5Department of Veterinary Clinical Medicine, College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia | ||
| چکیده | ||
| Background: Inflammatory bowel disease (IBD) in dogs is often characterized by a relapsing and remitting clinical course. Determination of inflammatory activity is important for assessing the disease extent, severity, and tailoring appropriate treatment. Aims: The study was conducted to record the macroscopic and microscopic changes associated with IBD to assess the usefulness of endoscopy in the diagnosis of the disease and to correlate the clinical activity index (CIBDAI) with endoscopic score. Methods: Thirty-three dogs with idiopathic IBD were selected after thorough examination and exclusion. Gastroduodenoscopy and colonoscopy were performed to document the gross macroscopic intestinal lesions. Histopathology of endoscopic aided biopsy samples was used to confirm the disease. Results: Mucosal erythema and increased friability were the most predominant endoscopic findings in the stomach, duodenum, and colon of IBD dogs. Lymphoplasmacytic infiltration was predominant in the mucosal samples on histopathology and diffuse form of IBD is more common in canines. Gastroduodenoscopy and colonoscopy in combination with endoscopically guided biopsy and histopathology are of value in the assessment and diagnosis of IBD. There was no correlation between the clinical inflammatory bowel disease activity index (CIBDAI) with the endoscopic score. Conclusion: A diffuse form of IBD and colitis is more common in dogs in comparison to human IBD where the disease manifests in two distinct forms. Colonoscopy with ileal biopsy could act as a gold standard in the confirmation of diffuse IBD in dogs. CIBDAI can be used as a reliable measure of clinical signs of inflammation and histopathology can be used as a definitive diagnosis of intestinal inflammation. | ||
| کلیدواژهها | ||
| Canine؛ CIBDAI؛ Endoscopy؛ Histopathology؛ IBD | ||
| مراجع | ||
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Allenspach, K; Wieland, B; Grone, A and Gaschen, F (2007). Chronic enteropathies in dogs: Evaluation of risk factors for negative outcome. J. Vet. Int. Med., 21: 700-708.
Casamian-Sorrosal, D; Willard, MD; Murray, JK; Hall, EJ; Taylor, SS and Day, MJ (2010). Comparison of histopathologic findings in biopsies from the duodenum and ileum of dogs with enteropathy. J. Vet. Intern. Med., 24: 80-83.
Cerquetella, M; Spaterna, A; Laus, F; Tesei, B; Rossi, E; Antonelli, G; Villanacci, V and Bassotti, G (2010). Inflammatory bowel disease in the dog: Differences and similarities with human. World J. Gastroenterol., 16: 1050-1056.
Day, MJ; Blizer, T; Mansell, J; Wilcock, B; Hall, EJ; Jergens, A; Minami, T; Willard, M and Washabau, R (2008). Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: A report from the World Small Animal Veterinary Association Gastrointestinal Standardi-zation Group. J. Comp. Pathol., 138: 38-43.
Garcia-Sancho, M; Rodriguez-Franco, F; Sainz, A; Mancho, C and Rodriguez, A (2007). Evaluation of clinical, macroscopic, and histopathologic response to treatment in nonhypoproteinemic dogs with lymphocytic-plasmacytic enteritis. J. Vet. Intern. Med., 21: 11-17.
Guilford, WG (1996). Idiopathic inflammatory bowel disease. In: Guilford, WG; Center, SA; Strombeck, DR; Williams, DA and Meyer, DJ (Eds.), Strombeck’s small animal gastroenterology. (3rd Edn.), W. B. Saunders, Philadelphia. PP: 451-486.
Guilford, WG (2005). Upper gastrointestinal endoscopy. In: McCarthy, M (Ed.), Veterinary endoscopy for the small animal practitioner. (1st Edn.), USA, Elsevier Saunders. PP: 279-322.
Hall, EJ and German, AJ (2010). Diseases of the small intestine. In: Ettinger, SJ and Feldman, EC (Eds.) Textbook of veterinary medicine - Diseases of the dog and the cat. (7th Edn.), Philadelphia, Saunders. PP: 1526-1572.
Heilmann, RM; Grellet, A and Allenspach, K (2014). Association between faecal S100A12 concentration and histologic, endoscopic, and clinical disease severity in dogs with idiopathic inflammatory bowel disease. Vet. Immunol. Immunopathol., 158: 156-166.
Jergens, AE; Crandell, J; Morrison, JA; Deitz, K; Pressel, M; Ackermann, M; Suchodolski, JS; Steiner, JM and Evans, R (2010a). Comparison of oral prednisone and prednisone combined with metronidazole for induction therapy of canine inflammatory bowel disease: A randomized-controlled trial. J. Vet. Intern. Med., 24: 269-277.
Jergens, AE; Evans, RB; Ackermann, M; Hostetter, J; Willard, M; Mansell, J; Bilzer, T; Wilcock, B; Washabau, R; Hall, EJ; Minami, T; Wang, C and Day, MJ (2010b). Design of a simplified histopathologic model for gastrointestinal inflammation in dogs. Vet. Pathol., 20: 1-5.
Jergens, AE and Moore, FM (2010). Endoscopic biopsy specimen collection and histopathologic considerations. In: Tams, TR (Ed.), Small animal endoscopy. (3rd Edn.), St. Louis, Mosby. PP: 323-340.
Jergens, AE; Moore, FM; Haynes, JS and Miles, KG (1992). Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987-1990). J. Am. Vet. Med. Assoc., 201: 1603-1608.
Jergens, AE; Schreiner, CA; Frank, DE; Niyo, Y; Ahrens, FE; Eckersall, PD; Benson, TJ and Evans, R (2003). A scoring index for disease activity in canine inflammatory bowel disease. J. Vet. Intern. Med., 17: 291-297.
Jergens, AE and Simpson, KW (2012). Inflammatory bowel disease in veterinary medicine. Front. Biosci. E4: 1404-1419.
Odze, R (2003). Diagnostic problems and advances in inflammatory bowel disease. Mod. Pathol., 16: 347-358.
Richter, KP (2005). Endoscopic evaluation of the colon. In: McCarthy, M (Ed.), Veterinary endoscopy for the small animal practitioner. (2nd Edn.), USA, Elsevier Saunders. PP: 323-356.
Slovak, JE; Wang, C; Sun, Y; Otoni, C and Morrison, J (2014). Development and validation of an endoscopic activity score for canine inflaymmatory bowel disease. Vet. J., 203: 290-295. Suchodolski, JS; Dowd, SE; Wilke, V; Steiner, JM and Jergens, AE (2012). 16S rRNA gene pyrosequencing reveals bacterial dysbiosis in the duodenum of dogs with idiopathic inflammatory bowel disease. PLoS One. 7: 333-339.
Suchodolski, JS; Steiner, JM and Evans, R (2010). Comparison of oral prednisone and prednisone combined with metronidazole for induction therapy of canine inflammatory bowel disease: A randomized-controlled trial. J. Vet. Int. Med., 24: 269-277.
Tams, TR (2010). Gastrointestinal endoscopy. In: Tams, TR (Ed.), Small animal endoscopy (3rd Edn.), St. Luis, C. V. Mosby Company. PP: 275-376.
Washabau, R; Day, M; Willard, M; Hall, EJ; Jergens, AE; Mansell, J; Minami, T and Bilzer, TW (2010). ACVIM consensus statement: Endoscopic, biopsy and histo-pathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J. Vet. Intern. Med., 24: 10-26.
Zoran, DL (2001). Gastroduodenoscopy in the dog and cat. Vet. Clin. Small Anim., 31: 631-656. | ||
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