| تعداد نشریات | 24 |
| تعداد شمارهها | 917 |
| تعداد مقالات | 8,230 |
| تعداد مشاهده مقاله | 16,274,702 |
| تعداد دریافت فایل اصل مقاله | 13,751,924 |
An investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattle | ||
| Iranian Journal of Veterinary Research | ||
| دوره 24، شماره 1 - شماره پیاپی 82، 2023، صفحه 51-57 اصل مقاله (965.77 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2022.43152.6282 | ||
| نویسندگان | ||
| E. Karakurt* 1؛ N. Coskun2؛ U. Aydın3؛ E. Beytut1؛ S. Dag1؛ V. S. Ataseven4؛ V. Yılmaz2؛ F. Dogan4؛ H. Nuhoglu5؛ C. S. Ermutlu3؛ M. Kuru6؛ A. Yıldız5 | ||
| 1Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey | ||
| 2Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey | ||
| 3Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey | ||
| 4Department of Virology, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Turkey | ||
| 5Ph.D. Student in Pathology, Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey | ||
| 6Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey | ||
| چکیده | ||
| Background: Ocular squamous cell carcinomas (OSCCs) in cattle has been studied for many years, but no definite etiology has been established. Squamous cell carcinomas (SCCs) may occur in different body parts of cattle. Depending on the location, it can cause an economic loss of varying degrees. Aims: The aim of this study was to investigate the causes of OSCCs in the eye region of cattle. Methods: Sixty tumoral masses taken form 60 cattle with proliferation in the eye region that were collected between the years 2012-2022 were used. These cases were admitted to our department for routine diagnosis. The tissues were diagnosed as OSCC using histopathological methods. The presence of bovine papillomavirus (BPV), one of the causative factors, was investigated using immunohistochemical and polymerase chain reaction (PCR). Results: Macroscopically masses were nodular or cauliflower-like and fragile and had hemorrhagic surfaces. Considering the keratin pearls, tumoral islands, and squamous differentiation, 20 out of 60 cases were classified as well, 20 as moderately, and 20 as poorly-differentiated OSCCs. 47 of the 60 cases were BPV positive using immunohistochemical methods. However, BPV nucleic acid was detected in only two cases with PCR. Only one of the cases could be sequenced. After phylogenetic analysis, virus strain was identified as BPV-1. Conclusion: Our results indicated that papillomaviruses can contribute to the development of OSCCs, in both precursor lesions and also advanced stage OSCCs. We found that BPV-1 has a possible causative role; however, more studies are needed to investigate the role of other viral agents and their interaction with secondary factors. | ||
| کلیدواژهها | ||
| Bovine papillomavirus؛ Immunohistochemistry؛ Ocular squamous cell carcinoma؛ PCR | ||
| مراجع | ||
|
Alloway, E; Linder, K; May, S; Rose, T; DeLay, J; Bender, S; Tucker, A and Luff, J (2020). A subset of Equine gastric squamous cell carcinomas is associated with equus caballus papillomavirus-2 infection. Vet. Pathol., 57: 427-431.
Altamura, G; Cardeti, G; Cersini, A; Eleni, C; Cocumelli, C; Bartolomé Del Pino, LE; Razzuoli, E; Martano, M; Maiolino, P and Borzacchiello, G (2020). Detection of Felis catus papillomavirus type-2 DNA and viral gene expression suggest active infection in feline oral squamous cell carcinoma. Vet. Comp. Oncol., 18: 494-501.
Altschul, SF; Madden, TL; Schäffer, AA; Zhang, J; Zhang, Z; Miller, W and Lipman, DJ (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res., 25: 3389-3402.
Armando, F; Mecocci, S; Orlandi, V; Porcellato, I; Cappelli, K; Mechelli, L; Brachelente, C; Pepe, M; Gialletti, R; Ghelardi, A; Passeri, B and Razzuoli, E (2021). Investigation of the epithelial to mesenchymal transition (EMT) process in Equine papillomavirus-2 (EcPV-2)-positive penile squamous cell carcinomas. Int. J. Mol. Sci., 22: 10588.
Beytut, E (2017). Pathological and immunohistochemical evaluation of skin and teat papillomas in cattle. Turk. J. Vet. Anim. Sci., 41: 204-212.
Carvalho, T; Vala, H; Pinto, C; Pinho, M and Peleteiro, MC (2005). Immunohistochemical studies of epithelial cell proliferation and p53 mutation in bovine ocular squamous cell carcinoma. Vet. Pathol., 42: 66-73.
Chang, CY; Chen, WT; Haga, T; Yamashita, N; Lee, CF; Tsuzuki, M and Chang, HW (2020). The detection and association of canine papillomavirus with benign and malignant skin lesions in dogs. Viruses. 12: 170.
Chu, S; Wylie, TN; Wylie, KM; Johnson, GC; Skidmore, ZL; Fleer, M; Griffith, OL and Bryan, JN (2020). A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors. Vet. Microbiol., 240: 108491.
Coşkun, N (2022). Investigation of DNA and RNA viruses from paraffin-embedded tissue blocks using molecular methods. J. Antakya Vet. Sci., 1: 9-12.
Cutarelli, A; De Falco, F; Uleri, V; Buonavoglia, C and Roperto, S (2021). The diagnostic value of the droplet digital PCR for the detection of bovine deltapapillomavirus in goats by liquid biopsy. Transbound. Emerg. Dis., 68: 3624-3630.
Emin, K; Nuvit, C; Serpil, D; Enver, B; Ataseven, VS; Volkan, Y; Firat, D; Hilmi, N; Celal Sahin, E; Ugur, A; Mushap, K and Ayfer, Y (2022). Molecular detection of Papillomavirus and immunohistochemical investigation of p53 gene expressions in bovine papillomas and fibro-papillomas. Arch Microbiol., 204: 278.
Ford, JN; Jennings, PA; Spradbrow, PB and Francis, J (1982). Evidence for papillomaviruses in ocular lesions in cattle. Res. Vet. Sci., 32: 257-259.
Fornazari, GA; Kravetz, J; Kiupel, M; Sledge, D; Filho, I and Montiani-Ferreira, F (2017). Ocular squamous cell carcinoma in Holstein cows from the South of Brazil. Vet. World. 10: 1413-1420.
Forslund, O; Antonsson, A; Nordin, P; Stenquist, B and Göran Hansson, B (1999). A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J. Gen. Virol., 80: 2437-2443.
Gharagozlou, MJ; Hekmati, P and Asrafihelan, J (2007). A clinical and histopathological study of ocular neoplasms in dairy cattle. Vet. Arh., 77: 409-426.
Greenwood, S; Chow-Lockerbie, B; Epp, T; Knight, C; Wachoski-Dark, G; MacDonald-Dickinson, V and Wobeser, B (2020). Prevalence and prognostic impact of Equus caballus papillomavirus type 2 infection in equine squamous cell carcinomas in western Canadian horses. Vet. Pathol., 57: 623-631.
Hall, TA (1999). BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp. Ser., 41: 95-98.
Hibi, H; Hatama, S; Obata, A; Shibahara, T and Kadota, K (2019). Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse. J. Vet. Med. Sci., 81: 1029-1033.
Karakurt, E; Aydın, U; Beytut, E; Dağ, S; Ermutlu, CŞ; Aksoy, Ö; Nuhoğlu, H; Yıldız, A and Kurtbaş, E (2021). Prognostic significance of PCNA, MMP-9 and p53 in bovine ocular squamous cell carcinomas. J. Res. Vet. Med., 40: 98-105.
Karakurt, E; Coşkun, N; Beytut, E; Keleş, ÖF; Dağ, S; Yılmaz, V; Nuhoğlu, H; Yıldız, A and Kurtbaş, E (2023). Evaluation of the relationship between in-flammatory reaction and interleukins in ovine pulmonary adenocarcinomas. Vet. Res. Forum. 14: 1-6.
Luff, J; Rowland, P; Mader, M; Orr, C and Yuan, H (2016). Two canine papillomaviruses associated with metastatic squamous cell carcinoma in two related Basenji dogs. Vet. Pathol., 53: 1160-1163.
Munday, JS; Dunowska, M; Laurie, RE and Hills, S (2016). Genomic characterization of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma. Vet. Microbiol., 182: 135-140.
Munday, JS; French, A and Harvey, CJ (2015). Molecular and immunohistochemical studies do not support a role for papillomaviruses in canine oral squamous cell carcinoma development. Vet. J., 204: 223-225.
Ogawa, T; Tomita, Y; Okada, M; Shinozaki, K; Kubonoya, H; Kaiho, I and Shirasawa, H (2004). Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin. J. Gen. Virol., 85: 2191-2197.
Pikor, LA; Enfield, KS; Cameron, H and Lam, WL (2011). DNA extraction from paraffin-embedded material for genetic and epigenetic analyses. J. Vis. Exp., 49: 2763.
Podarala, V; Prasanna Lakshmi, M; Venkata, S and Devalam, RP (2020). Efficacy of BCG vaccine and Mitomycin C for the treatment of ocular squamous cell carcinoma in bovines. Res. Vet. Sci., 133: 48-52.
Pugliese, M; Mazzullo, G; Niutta, PP and Passantino, A (2014). Bovine ocular squamous cell carcinoma: a report of cases from the Caltagirone area, Italy. Vet. Arh., 84: 449-457.
Ramsauer, AS; Kubacki, J; Favrot, C; Ackermann, M; Fraefel, C and Tobler, K (2019). RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events. J. Gen. Virol., 100: 985-998.
Rutten, VP; Klein, WR; De Jong, MA; Quint, W; Den Otter, W; Ruitenberg, EJ and Melchers, WJ (1992). Search for bovine papilloma virus DNA in bovine ocular squamous cell carcinomas (BOSCC) and BOSCC-derived cell lines. Am. J. Vet. Res., 53: 1477-1481.
Sabattini, S; Savini, F; Gallina, L; Scagliarini, A; Bassi, P and Bettini, G (2016). p16 immunostaining of canine squamous cell carcinomas is not associated with papillomaviral DNA. PloS One. 11: e0159687.
Sambrook, J and Russell, DW (2001). Molecular cloning: a laboratory manual. 3rd Edn., New York, USA, Cold Spring Harbor Laboratory Press. PP: 4-8.
Sözmen, M; Devrim, AK; Sudağıdan, M; Kabak, YB; Beytut, E and Özba, B (2019). Significance of angiogenic growth factors in bovine ocular squamous cell carcinoma. J. Comp. Pathol., 170: 60-69. Tamura, K; Peterson, D; Peterson, N; Stecher, G; Nei, M and Kumar, S (2011). MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol., 28: 2731-2739.
Tsujita, H and Plummer, CE (2010). Bovine ocular squamous cell carcinoma. Vet. Clin. North Am. Food Anim. Pract., 26: 511-529.
Vala, H; Carvalho, T; Pinto, C; Pereira, MA; Mesquita, JR; C Peleteiro, M; Ferrer, L and Fondevila, D (2020). Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma. Vet. Sci., 7: 70.
Yamashita-Kawanishi, N; Gushino, Y; Chang, CY; Chang, HW; Chambers, JK; Uchida, K and Haga, T (2021). Full-genome characterization of a novel Felis catus papillomavirus 4 subtype identified in a cutaneous squamous cell carcinoma of a domestic cat. Virus Genes. 57: 380-384.
Yamashita-Kawanishi, N; Sawanobori, R; Matsumiya, K; Uema, A; Chambers, JK; Uchida, K; Shimakura, H; Tsuzuki, M; Chang, CY; Chang, HW and Haga, T (2018). Detection of felis catus papillomavirus type 3 and 4 DNA from squamous cell carcinoma cases of cats in Japan. J. Vet. Med. Sci., 80: 1236-1240.
Yamashita-Kawanishi, N; Tsuzuki, M; Wei, Z; Kok, MK; Ishiyama, D; Chambers, JK; Uchida, K; Dong, J; Shimakura, H and Haga, T (2019). Identification of bovine papillomavirus type 1 and 2 from bovine anogenital fibropapillomas. J. Vet. Med. Sci., 81: 1000-1005. | ||
|
آمار تعداد مشاهده مقاله: 1,283 تعداد دریافت فایل اصل مقاله: 859 |
||