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برگزاری کارگاه اصول انتشار کتاب در ناشران بین‌المللی
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فیلم دوره آموزشی هوش مصنوعی: SWOT و سیاست‌های ناشران بین‌المللی
ارتقاء رتبه نشریه علمی «شعرپژوهی» دانشگاه شیراز در ارزیابی سامانه رتبه‌بندی نشریات کشور
افتخارآفرینی دبیران مجلات علمی دانشگاه شیراز در عرصۀ بین‌المللی
اطلاعیه برگزاری دوره آموزشی هوش مصنوعی: SWOT و سیاست‌های ناشران بین‌المللی در تاریخ 19 خرداد 1404
ارتقاء رتبۀ مجلۀ علوم ایران از Q3 به Q2

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Messal, Ahlem, Abid, Ghania, Abdi, Meriem, Idder, Aicha, Meroufel, Naima, Zemani-Fodil, Faouzia, Fodil, Mostefa. (1402). Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population. , 12(2), 57-62. doi: 10.22099/mbrc.2023.46767.1809
Ahlem Messal; Ghania Abid; Meriem Abdi; Aicha Idder; Naima Meroufel; Faouzia Zemani-Fodil; Mostefa Fodil. "Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population". , 12, 2, 1402, 57-62. doi: 10.22099/mbrc.2023.46767.1809
Messal, Ahlem, Abid, Ghania, Abdi, Meriem, Idder, Aicha, Meroufel, Naima, Zemani-Fodil, Faouzia, Fodil, Mostefa. (1402). 'Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population', , 12(2), pp. 57-62. doi: 10.22099/mbrc.2023.46767.1809
Messal, Ahlem, Abid, Ghania, Abdi, Meriem, Idder, Aicha, Meroufel, Naima, Zemani-Fodil, Faouzia, Fodil, Mostefa. Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population. , 1402; 12(2): 57-62. doi: 10.22099/mbrc.2023.46767.1809

Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population

Molecular Biology Research Communications
دوره 12، شماره 2، 2023، صفحه 57-62    اصل مقاله (138.88 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.46767.1809
نویسندگان
Ahlem Messal* 1، 2؛ Ghania Abid1، 2؛ Meriem Abdi1، 2؛ Aicha Idder2، 3؛ Naima Meroufel1، 2؛ Faouzia Zemani-Fodil1، 2؛ Mostefa Fodil4
1Laboratory of molecular and cellular biology, Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf, USTO-MB, Oran, Algeria
2Thematic Agency for Research in Health Sciences ATRSS, Algeria
3Laboratory of medical genetic applied in ophthalmology, «Hammou Boutlilis» Ophthalmology Hospital, Oran, Algeria
4BiOSSE (Biology of Organisms: Stress, Health, Environment), Le Mans University, F-72085 Le Mans, France
چکیده
Neovascular age-related macular degeneration (nAMD) is a progressive ocular disease, responsible for central visual loss and blindness in elderly population. Increase data demonstrate that genetic factors play an important role in pathogenesis process of this disease. The aim of this study is to investigate the association between rs3732378 polymorphism in CX3CR1 gene and nAMD in a sample of Algerian patients. This case-control study consisted of 72 patients with nAMD and 124 control subjects. DNA of participants was extracted using salting out method. Genotyping was carried out using the TaqMan real-time polymerase chain reaction method. Statistical analysis was performed by SPSS.21.0. The prevalence of the risk genotype AA was higher in the nAMD group than in control group (OR=5.02, 95% CI=1.44-17.4, P=0.011). In our sample of Algerian patients, the rs3732378 polymorphism is associated with nAMD. This result may support the role of CX3CR1 gene in the pathogenesis of nAMD.  
کلیدواژه‌ها
Neovascular age-related macular degeneration؛ CX3CR1؛ polymorphism؛ Algerian population
مراجع
  1. Al-Zamil W, Yassin S. Recent developments in age-related macular degeneration: a review. Clin Interv Aging 2017;12:1313-1330.
  2. Heesterbeek TJ, Lorés-Motta L, Hoyng CB, Lechanteur YTE, den Hollander AI. Risk factors for progression of age-related macular degeneration. Ophthalmic Physiol Opt 2020;40:140-170.
  3. Husain D, Ambati B, Adamis AP, Miller JW. Mechanisms of age-related macular degeneration. Ophthalmol Clin North Am 2002;15:87-91.
  4. Schmidt S, Saunders AM, Paz MA DL, Postel EA, Heinis RM, Agarwal A, Scott WK, Gilbert JR, McDowell JG, Bazyk A, Gass JD, Haines JL, Pericak-Vance MA. Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. Mol Vis 2000;6:287-293
  5. Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002;134:411-431.
  6. Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 2003;9:1390-1397.
  7. Espinosa-Heidmann DG, Suner IJ, Hernandez EP, Monroy D, Csaky KG, Cousins SW. Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2003;44:3586-3592.
  8. Sakurada Y, Nakamura Y, Yoneyama S, Mabuchi F, Gotoh T, Tateno Y, Sugiyama A, Kubota T, Iijima H. Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Ophthalmic Res 2015;53: 2-7.
  9. CX3CR1 C-X3-C motif chemokine receptor 1 [Homo sapiens (human)] - Gene - NCBI [Gene ID: 1524, updated on 22 Jan 2023]. https://www.ncbi.nlm.nih.gov/gene/1524#gene-expression.
  10. Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997;91:521-530.
  11. Combadiere C, Salzwedel K, Smith ED, Tiffany HL, Berger EA, Murphy PM. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J Biol Chem 1998;273:23799-23804.
  12. Wong BW, Wong D, McManus BM. Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease. Cardiovasc Pathol 2002;11:332-338.
  13. Timofeeva AV, Goryunova LE, Khaspekov GL, Kovalevskii DA, Scamrov AV, Bulkina OS, Karpov YA, Talitskii KA, Buza VV, Britareva VV, Beabealashvilli Rs. Altered gene expression pattern in peripheral blood leukocytes from patients with arterial hypertension. Ann N Y Acad Sci 2006;1091:319-335.
  14. Volin MV, Woods JM, Amin MA, Connors MA, Harlow LA, Koch AE. Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis. Am J Pathol 2001;159:1521-1530.
  15. Efsen E, Grappone C, DeFranco RM, Milani S, Romanelli RG, Bonacchi A, Caligiuri A, Failli P, Annunziato F, Pagliai G, Pinzani M, Laffi G, Gentilini P, Marra F. Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans. J Hepatol 2002;37:39-47.
  16. Foussat A, Bouchet-Delbos L, Berrebi D, Durand-Gasselin I, Coulomb- L'Hermine A, Krzysiek R, Galanaud P, Levy Y, Emilie D. Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients. Blood 2001;98:1678-1686.
  17. Fujimura S, Takahashi H, Yuda K, Ueta T, Iriyama A, Inoue T, Kaburaki T, Tamaki Y, Matsushima K, Yanagi Y. Angiostatic effect of CXCR3 expressed on choroidal neovascularization. Invest Ophthalmol Vis Sci 2012;53:1999-2006.
  18. Falk MK, Singh A, Faber C, Nissen MH, Hviid T, Sørensen TL. CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. PLoS One 2014;9:e112473.
  19. Ma B, Dang G, Yang S, Duan L, Zhang Y. CX3CR1 polymorphisms and the risk of age-related macular degeneration. Int J Clin Exp Pathol 2015;8:9592-9596.
  20. Schaumberg DA, Rose L, DeAngelis MM, Semba RD, Hageman GS, Chasman DI. A prospective study of common variants in the CX3CR1 gene and risk of macular degeneration: pooled analysis from five long-term studies. JAMA Ophthalmol 2014;132:84-95.
  21. Anastasopoulos E, Kakoulidou A, Coleman AL, Sinsheimer JS, Wilson MR, Yu F, Salonikiou A, Koskosas A, Pappas T, Founti P, Lambropoulos A, Topouzis F. Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. Curr Eye Res 2012;37:1148-1155.
  22. Gupta D, Gupta V, Singh V, Chawla S, Parveen F, Agrawal S, Phadke SR. Study of Polymorphisms in CX3CR1, PLEKHA1 and VEGF genes as risk factors for age-related macular degeneration in Indian patients. Arch Med Res 2014;45:489-494.
  23. Stahl A. The diagnosis and treatment of age-related macular degeneration. Dtsch Arztebl Int 2020;20;117:513-520.
  24. Nécessité d’une prise en charge thérapeutique de la «DMLA» [Internet]. Djazairess. [cité 5 déc 2021]. Disponible sur: https://www.djazairess.com/fr/lnr/276128.
  25. Colijn JM, Meester-Smoor M, Verzijden T, de Breuk A, Silva R, Merle BMJ, Cougnard-Gregoire A, Hoyng CB, Fauser S, Coolen A, Creuzot-Garcher C, Werner Hense H, Ueffing M, Delcourt C, den Hollander AI, Klaver C, Consortium ER. Genetic Risk, Lifestyle, and age-related macular degeneration in Europe. The EYE-Risk Consortium. Ophthalmology 2021;128:1039-1049.
  26. Woo SJ, Ahn J, Morrison MA, Ahn SY, Lee J, Kim KW, DeAngelis MM, Park KH. Analysis of genetic and environmental risk factors and their interactions in Korean patients with age-related macular degeneration. PLoS One 2015;10:e0132771.
  27. Chen LJ. Genetic association of age-related macular degeneration and polypoidal choroidal vasculopathy. Asia Pac J Ophthalmol (Phila) 2020;9:104-109.
  28. Yang X, Hu J, Zhang J, Guan H. Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. Br J Ophthalmol 2010;94: 1211-1214.
  29. Hu J, Yuan Y, Shen L, Zhang J, Hu N, Guan H. Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a Han Chinese control population. Ophthalmic Epidemiol 2011;18:137-142.
  30. Li D, Peng X, Sun H. Association of CX3CR1 (V249I and T280M) polymorphisms with age-related macular degeneration: a meta-analysis. Can J Ophthalmol 2015;50:451-460.
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