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Saify, Khyber. (1401). The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha. , 12(1), 51-55. doi: 10.22099/mbrc.2023.46890.1813
Khyber Saify. "The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha". , 12, 1, 1401, 51-55. doi: 10.22099/mbrc.2023.46890.1813
Saify, Khyber. (1401). 'The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha', , 12(1), pp. 51-55. doi: 10.22099/mbrc.2023.46890.1813
Saify, Khyber. The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha. , 1401; 12(1): 51-55. doi: 10.22099/mbrc.2023.46890.1813

The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha

Molecular Biology Research Communications
دوره 12، شماره 1، 2023، صفحه 51-55    اصل مقاله (233.22 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2023.46890.1813
نویسنده
Khyber Saify*
Department of Biology, College of Education Sciences, Kunduz University, Kunduz, Afghanistan
چکیده
Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system. HLA genes are classified into three classes (I, II, and III). The HLA-DQB1 belongs to class II, is mainly involved in the actions of the human immune system and plays a fundamental role in donor-recipient matching in transplantation and can be associated with most autoimmune diseases. In this study, the potential influence(s) of the G-71C (rs71542466) and T-80C (rs9274529) genetic polymorphisms were investigated. These polymorphisms, located in the HLA-DQB1 promoter region, have a significant frequency in the world population. The online software ALGGEN-PROMO.v8.3 was used in this work. The results indicate that the C allele at the -71 position actually creates a new potential binding site for NF1/CTF and the C allele at the -80 position changes the TFII-D binding site into a GR-alpha response element. The NF1/CTF plays the role of activator and the GR-alpha is the inhibitor; thus, according to the roles of these transcription factors, it is suggested that the above-mentioned polymorphisms alter the expression levels of HLA-DQB1. Therefore, this genetic variation is associated with autoimmune diseases; however, this cannot be generalized because this is the first report and more studies are needed in the future.
کلیدواژه‌ها
GR-alpha؛ HLA-DQB1؛ NF1/CTF؛ Polymorphism
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