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Maleki, Mohsen, Karajibani, Mansour, Saravani, Mohsen, Montazerifar, Farzaneh, Salimi, Saeedeh, Heidari, Zahra. (1401). Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer. , 11(3), 113-118. doi: 10.22099/mbrc.2022.43012.1714
Mohsen Maleki; Mansour Karajibani; Mohsen Saravani; Farzaneh Montazerifar; Saeedeh Salimi; Zahra Heidari. "Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer". , 11, 3, 1401, 113-118. doi: 10.22099/mbrc.2022.43012.1714
Maleki, Mohsen, Karajibani, Mansour, Saravani, Mohsen, Montazerifar, Farzaneh, Salimi, Saeedeh, Heidari, Zahra. (1401). 'Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer', , 11(3), pp. 113-118. doi: 10.22099/mbrc.2022.43012.1714
Maleki, Mohsen, Karajibani, Mansour, Saravani, Mohsen, Montazerifar, Farzaneh, Salimi, Saeedeh, Heidari, Zahra. Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer. , 1401; 11(3): 113-118. doi: 10.22099/mbrc.2022.43012.1714

Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer

Molecular Biology Research Communications
دوره 11، شماره 3، 2022، صفحه 113-118    اصل مقاله (145.38 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2022.43012.1714
نویسندگان
Mohsen Maleki1؛ Mansour Karajibani* 2؛ Mohsen Saravani3؛ Farzaneh Montazerifar4؛ Saeedeh Salimi5؛ Zahra Heidari6
1Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3Cellular and Molecular Research Center, Research Institue of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
4Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
5Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
6Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
About 60-80% of thyroid cancer (TC) cases are papillary thyroid cancer (PTC). Studies have shown that serum adiponectin levels are inversely related to the risk of TC and PTC. Aim of the present study was to evaluate the association between adiponectin rs2241766 and rs266729 polymorphisms and risk of PTC. 122 PTC patients and 128 healthy subjects were enrolled in the study. PCR-RFLP and ARMS-PCR methods were used for genotype analysis. The rs266729 polymorphism did not correlate with risk of PTC. As regard rs2241766 polymorphism, the frequency of the GG genotype did not have a significant difference between the two groups, although, PTC cases showed higher frequency of GT genotype compared to controls (OR=2.87, 95% CI=1.56-5.28, P=0.001). We observed a significant association between adiponectin rs2241766 polymorphism and PTC, however, our result showed no significant relationship between adiponectin rs266729 polymorphism and risk of PTC.
کلیدواژه‌ها
Adiponectin؛ Papillary thyroid cancer؛ Polymorphism
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