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Pimenta, Ruan, Viana, Nayara, dos Santos, Gabriel, Candido, Patricia, Guimaraes, Vanessa, Romao, Poliana, Silva, Iran, de Camargo, Juliana, Hatanaka, Dina, Queiroz, Paula, Teruya, Alexandre, Echenique, Leandro, Besen, Bruno, Leite, Katia, Srougi, Victor, Srougi, Miguel, Reis, Sabrina. (1400). MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19. , 10(3), 141-147. doi: 10.22099/mbrc.2021.40555.1631
Ruan Pimenta; Nayara I Viana; Gabriel A dos Santos; Patricia Candido; Vanessa R Guimaraes; Poliana Romao; Iran A Silva; Juliana A de Camargo; Dina M Hatanaka; Paula G S Queiroz; Alexandre Teruya; Leandro Echenique; Bruno A M P Besen; Katia R M Leite; Victor Srougi; Miguel Srougi; Sabrina T Reis. "MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19". , 10, 3, 1400, 141-147. doi: 10.22099/mbrc.2021.40555.1631
Pimenta, Ruan, Viana, Nayara, dos Santos, Gabriel, Candido, Patricia, Guimaraes, Vanessa, Romao, Poliana, Silva, Iran, de Camargo, Juliana, Hatanaka, Dina, Queiroz, Paula, Teruya, Alexandre, Echenique, Leandro, Besen, Bruno, Leite, Katia, Srougi, Victor, Srougi, Miguel, Reis, Sabrina. (1400). 'MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19', , 10(3), pp. 141-147. doi: 10.22099/mbrc.2021.40555.1631
Pimenta, Ruan, Viana, Nayara, dos Santos, Gabriel, Candido, Patricia, Guimaraes, Vanessa, Romao, Poliana, Silva, Iran, de Camargo, Juliana, Hatanaka, Dina, Queiroz, Paula, Teruya, Alexandre, Echenique, Leandro, Besen, Bruno, Leite, Katia, Srougi, Victor, Srougi, Miguel, Reis, Sabrina. MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19. , 1400; 10(3): 141-147. doi: 10.22099/mbrc.2021.40555.1631

MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19

Molecular Biology Research Communications
دوره 10، شماره 3، 2021، صفحه 141-147    اصل مقاله (359.81 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2021.40555.1631
نویسندگان
Ruan Pimenta* 1؛ Nayara I Viana1؛ Gabriel A dos Santos1؛ Patricia Candido1؛ Vanessa R Guimaraes1؛ Poliana Romao1؛ Iran A Silva1؛ Juliana A de Camargo1؛ Dina M Hatanaka2؛ Paula G S Queiroz2؛ Alexandre Teruya2؛ Leandro Echenique2؛ Bruno A M P Besen3؛ Katia R M Leite1؛ Victor Srougi1؛ Miguel Srougi1، 2؛ Sabrina T Reis1، 2
1Laboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
2Moriah Hospital, São Paulo, SP, Brazil
3Instituto Central, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de SaoPaulo, Sao Paulo, SP, Brazil
چکیده
COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It is speculated that microRNAs may play a crucial role in host cells after infection by SARS-CoV-2. Thus, our study aimed to analyze the expression of miR-200c-3p in saliva samples from patients with COVID-19. One handred eleven samples from patients with COVID-19 were divided into 4 groups. Group I: 39 patients negative for Covid-19; Group II: 37 positive and symptomatic patients, with no indication of hospitalization; Group III: 21 patients with respiratory disorders (hospitalized); Group IV: 14 patients with severe conditions (oxygen therapy). The expression levels of miR-200c-3p were determined using qPCR. We found greater expression of miR-200c-3p in patients in group IV (p <0.0001), and also verified that patients aged ≥42 years had a higher expression of this miR (p =0.013). Logistic regression analysis revealed that the expression of miR-200c-3p and systemic arterial hypertension are factors independently associated with patients in group IV (p <0.0001). Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2.
کلیدواژه‌ها
microRNA؛ COVID-19؛ SARs-CoV-2؛ Biomarkers
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