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The anti-proliferative and apoptotic effects of curcumin on feline mammary gland tumor cells in vitro | ||
| Iranian Journal of Veterinary Research | ||
| دوره 22، شماره 3 - شماره پیاپی 76، 2021، صفحه 222-229 اصل مقاله (1004.92 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2021.40452.5866 | ||
| نویسندگان | ||
| A. Deveci Ozkan1؛ G. Guney Eskiler1؛ O. Turna* 2؛ N. Kazan3؛ E. Sozen Kucukkara4؛ A. Baykal5؛ K. Sonmez6 | ||
| 1Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey | ||
| 2Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey | ||
| 3MSc Student in Medical Biology, Department of Medical Biology, Institute of Health Science, Sakarya University, Sakarya, Turkey | ||
| 4Ph.D. Student in Biochemistry, Department of Medical Biochemistry, Institute of Health Science, Sakarya University, Sakarya, Turkey | ||
| 5Ph.D. Student in Gynecology, Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey | ||
| 6Department of Pathology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey | ||
| چکیده | ||
| Background: Feline mammary gland tumors (FMGTs) are the third most diagnosed tumors in cats. Feline mammary gland tumors have aggressive biological behavior and poor response to both surgical and medical treatments, thus, new therapeutic approaches are essential to improve. Curcumin (CUR) is a polyphenol component exhibiting anti-cancer effects and induces apoptosis through different mechanisms especially in human breast cancer. However, there is no study investigating the effects of CUR on FMGTs. Aims: The aim of this study was to determine the anti-proliferative and apoptotic effects of CUR on primary cell lines from FMGT tissue samples of two cases classified as carcinoma-simple, tubular type (grade III). Methods: The cytotoxic effect of CUR was determined by water-soluble tetrazolium salt-1 (WST-1) assay. Annexin V, cell cycle, and acridine orange (AO) analyses were performed to determine the apoptotic effect of CUR. Results: Our results showed that CUR had an anti-proliferative and apoptotic effect through induction of apoptosis and cell cycle arrest (G0/G1) on FMGT cells. Conclusion: Therefore, this is the first study that shows the effects of CUR on FMGTs. However, further molecular studies are required to compare the effects of CUR on different histopathological phenotypes and to determine the further molecular mechanisms including the potential apoptotic and cellular pathways affected by CUR. | ||
| کلیدواژهها | ||
| Apoptosis؛ Cell cycle؛ Curcumin؛ Feline mammary gland tumor | ||
| مراجع | ||
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