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Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease | ||
| Molecular Biology Research Communications | ||
| دوره 10، شماره 2، 2021، صفحه 55-61 اصل مقاله (303.89 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2021.39141.1574 | ||
| نویسندگان | ||
| Mahsa Eskandari1؛ Ali Awsat Mellati1؛ khalil Mahmoodi2؛ Koorosh Kamali3؛ Mohammad Soleiman Soltanpour* 4 | ||
| 1Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| 2Department of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| 3Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| 4Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| چکیده | ||
| Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, p <0.001) was significantly associated with CAD risk. Further analysis identified CYP1A1 rs4646903 polymorphism as a significant risk factor for early onset (P= 0.005) but not late onset (P=0.066) CAD. However, the frequency of heterozygous and homozygous mutant genotype of rs4646903 polymorphism did not differ significantly among the CAD patients with various number of stenotic vessel (P>0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD. | ||
| کلیدواژهها | ||
| Coronary artery disease؛ CYP1A1؛ rs4646903؛ Polymorphism؛ PCR-RFLP | ||
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