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Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients | ||
| Molecular Biology Research Communications | ||
| دوره 9، شماره 4، 2020، صفحه 169-172 اصل مقاله (188.64 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2020.37397.1508 | ||
| نویسندگان | ||
| Abhaya Gupta1؛ Neetu Singh2؛ Anil Kumar2؛ Umesh Pratap Verma* 1؛ Ajay Kumar Verma3؛ Hari Shyam2؛ Nand Lal1؛ Surya Kant3؛ Ankur Kumari1 | ||
| 1Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| 2Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| 3Department of Respiratory Medicine, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| چکیده | ||
| The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (p <0.0001) in B+CP while LTB (p <0.0001), TNFSF4 (P=0.0003), TNFSF11 (p <0.0001), TNFSF13 (P=0.0003), TNFSF13B (p <0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis. | ||
| کلیدواژهها | ||
| Tumor necrosis factor superfamily؛ Lymphotoxin A gene؛ Bronchiectasis؛ Chronic periodontitis؛ Expression | ||
| مراجع | ||
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1. Gomes-Filho IS, da Cruz SS, Trindade SC, Passos-Soares JS, Carvalho-Filho PC, Figueiredo ACMG, Lyrio AO, Hintz AM, Pereira MG, Scannapieco F. Periodontitis and respiratory diseases: A systematic review with meta-analysis. Oral Dis 2020;26:439-446. 2. Henkle E, Chan B, Curtis JR, Aksamit TR, Daley CL, Winthrop KL. Characteristics and health-care utilization history of patients with bronchiectasis in US medicare enrollees with prescription drug plans, 2006 to 2014. Chest 2018;154:1311-1320.Top of FormBottom of Form 3. Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000.2014;64:57-80. 4. Boyton RJ, Altmann DM. Bronchiectasis: current concepts in pathogenesis, immunology, and microbiology. Annu Rev Pathol 2016;11:523-554. 5. Vasconcelos DFP, da Silva MAD, Marques MR, de Brito Junior RB, Vasconcelos ACCG, Barros SP. Lymphotoxin-alpha gene polymorphism +252A/G (rs909253, A/G) is associated with susceptibility to chronic periodontitis: A pilot study. ISRN Dent 2012;2012:617245. 6. Danilko KV, Korytina GF, Akhmidishina LZ, Ianbaeva DG, Zagidullin S, Victorova TV. [Association of cytokines genes (ILL, IL1RN, TNF, LTA, IL6, IL8, ILo) Polymorphic markers with chronic obstructive pulmonary disease.] Mol Biol (Mosk) 2007;41:26-36. [Article in Russian] 7. Suzuki A, Horie T, Numabe Y. Investigation of molecular biomarker candidates for diagnosis and prognosis of chronic periodontitis by bioinformatics analysis of pooled microarray gene expression datasets in Gene Expression Omnibus (GEO). BMC Oral Health 2019;19:52. 8. Singh D, Fox SM, Singer RT, Bates S, Riley JH, Celli B. Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort. PLoS One 2014; 9:e107381. | ||
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