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Gupta, Abhaya, Singh, Neetu, Kumar, Anil, Verma, Umesh Pratap, Verma, Ajay Kumar, Shyam, Hari, Lal, Nand, Kant, Surya, Kumari, Ankur. (1399). Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients. , 9(4), 169-172. doi: 10.22099/mbrc.2020.37397.1508
Abhaya Gupta; Neetu Singh; Anil Kumar; Umesh Pratap Verma; Ajay Kumar Verma; Hari Shyam; Nand Lal; Surya Kant; Ankur Kumari. "Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients". , 9, 4, 1399, 169-172. doi: 10.22099/mbrc.2020.37397.1508
Gupta, Abhaya, Singh, Neetu, Kumar, Anil, Verma, Umesh Pratap, Verma, Ajay Kumar, Shyam, Hari, Lal, Nand, Kant, Surya, Kumari, Ankur. (1399). 'Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients', , 9(4), pp. 169-172. doi: 10.22099/mbrc.2020.37397.1508
Gupta, Abhaya, Singh, Neetu, Kumar, Anil, Verma, Umesh Pratap, Verma, Ajay Kumar, Shyam, Hari, Lal, Nand, Kant, Surya, Kumari, Ankur. Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients. , 1399; 9(4): 169-172. doi: 10.22099/mbrc.2020.37397.1508

Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients

Molecular Biology Research Communications
دوره 9، شماره 4، 2020، صفحه 169-172    اصل مقاله (188.64 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22099/mbrc.2020.37397.1508
نویسندگان
Abhaya Gupta1؛ Neetu Singh2؛ Anil Kumar2؛ Umesh Pratap Verma* 1؛ Ajay Kumar Verma3؛ Hari Shyam2؛ Nand Lal1؛ Surya Kant3؛ Ankur Kumari1
1Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India
2Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India
3Department of Respiratory Medicine, King George’s Medical University, Uttar Pradesh, Lucknow, India
چکیده
The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (p <0.0001) in B+CP while LTB (p <0.0001), TNFSF4 (P=0.0003), TNFSF11 (p <0.0001), TNFSF13 (P=0.0003), TNFSF13B (p <0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.
کلیدواژه‌ها
Tumor necrosis factor superfamily؛ Lymphotoxin A gene؛ Bronchiectasis؛ Chronic periodontitis؛ Expression
مراجع

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