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Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients | ||
| Molecular Biology Research Communications | ||
| دوره 9، شماره 4، 2020، صفحه 169-172 اصل مقاله (188.64 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2020.37397.1508 | ||
| نویسندگان | ||
| Abhaya Gupta1؛ Neetu Singh2؛ Anil Kumar2؛ Umesh Pratap Verma* 1؛ Ajay Kumar Verma3؛ Hari Shyam2؛ Nand Lal1؛ Surya Kant3؛ Ankur Kumari1 | ||
| 1Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| 2Department of Molecular Biology, Center for Advanced Research, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| 3Department of Respiratory Medicine, King George’s Medical University, Uttar Pradesh, Lucknow, India | ||
| چکیده | ||
| The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (p <0.0001) in B+CP while LTB (p <0.0001), TNFSF4 (P=0.0003), TNFSF11 (p <0.0001), TNFSF13 (P=0.0003), TNFSF13B (p <0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis. | ||
| کلیدواژهها | ||
| Tumor necrosis factor superfamily؛ Lymphotoxin A gene؛ Bronchiectasis؛ Chronic periodontitis؛ Expression | ||
| مراجع | ||
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