| تعداد نشریات | 24 |
| تعداد شمارهها | 907 |
| تعداد مقالات | 8,106 |
| تعداد مشاهده مقاله | 15,506,338 |
| تعداد دریافت فایل اصل مقاله | 13,154,111 |
Association of two single nucleotide polymorphisms rs10407022 and rs3741664 with the risk of primary ovarian insufficiency in a sample of Iraqi women | ||
| Molecular Biology Research Communications | ||
| دوره 9، شماره 4، 2020، صفحه 141-144 اصل مقاله (83.69 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2020.36371.1477 | ||
| نویسندگان | ||
| Tamadher Abbas Rafaa1؛ Ahmed Abduljabar Suleiman* 2؛ Mustafa Falah Dawood3؛ Ali Mohammad Al-Rawi1 | ||
| 1University Headquarter, University of Anbar, Ramadi, Iraq | ||
| 2College of Science, University of Anbar, Ramadi, Iraq | ||
| 3College of Education for Pure Science, University of Anbar, Ramadi, Iraq | ||
| چکیده | ||
| Primary ovarian insufficiency (POI) can be a devastating disease impacting women below the age of forty. This involves a major decrease in the amount and quality of oocytes, or ovarian reserve in a woman. The distribution of single-nucleotide polymorphisms, rs10407022 and rs3741664, in Iraqi people and its association with primary ovarian insufficiency is the main objective of this study. The mean of FSH and LH levels of patients with POI was higher than control, while the mean of AMH levels of patients was lower compared to control. For rs10407022, the GT and TT genotypes were positively associated with the risk of POI. For the rs3741664, the AG genotype was negatively associated with the risk of POI. The results lead to the main conclusion that rs10407022 and rs3741664 polymorphisms may significantly affected the serum levels of AMH and FSH and thus affect POI etiology. | ||
| کلیدواژهها | ||
| Tetra arms PCR؛ POI؛ AMH؛ FSH؛ LH | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
1. Rafique S, Sterling EW, Nelson LM. A new approach to primary ovarian insufficiency. Obstet Gynecol Clin North Am 2012;39:567-586. 2. Cox L, Liu JH. Primary ovarian insufficiency: an update. Int J Womens Health 2014;235.243. 3. Torrealday S, Kodaman P, Pal L. Premature ovarian insufficiency - an update on recent advances in understanding and management. F1000Res 2017;6:2069. 4. Fenton AJ. Premature ovarian insufficiency: Pathogenesis and management. J Midlife Health 2015;6:147-153. 5. Grynnerup AGA, Lindhard A, Sorensen S. The role of anti-Müllerian hormone in female fertility and infertility - an overview. Acta Obstet Gynecol Scand 2012;91:1252-1260. 6. Kruszyńska A, Słowińska-Srzednicka J. Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Prz Menopauzalny 2017;16:47-50. 7. Visser JA, Schipper I, Laven JSE, Themmen A. Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency. Nat Rev Endocrinol 2012;8:331-341. 8. Knauff EAH, Eijkemans MJC, Lambalk CB, Ten Kate-Booij MJ, Hoek A, Beerendonk CCM, Themmen AP, de Jong FH, Fauser BC. Anti-Müllerian hormone, inhibin B, and antral follicle count in young women with ovarian failure. J Clin Endocrinol Metab 2009;94:786-792. 9. La Marca A, Brozzetti A, Sighinolfi G, Marzotti S, Volpe A, Falorni A. Primary ovarian insufficiency: autoimmune causes. Curr Opin Obstet Gynecol 2010;22:277-282. 10. Usta T, Oral E. Is the measurement of anti-Müllerian hormone essential? Curr Opin Obstet Gynecol 2012;24:151-157. 11. Peluso C, Fonseca FLA, Gastaldo GG, Christofolini DM, Cordts EB, Barbosa CP, Bianco B. AMH and AMHR2 polymorphisms and AMH serum level can predict assisted reproduction outcomes: A cross-sectional study. Cell Physiol Biochem 2015;35:1401-1412. 12. Jurczak A, Szkup M, Grzywacz A, Safranow K, Grochans E. The relationship between AMH and AMHR2 polymorphisms and the follicular phase in late reproductive stage women. Int J Environ Res Public Health 2016;13:185. 13. Kevenaar ME, Themmen APN, Laven JSE, Sonntag B, Fong SL, Uitterlinden AG, de Jong FH, Pols HA, Simoni M, Visser JA. Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women. Hum Reprod 2007;22:1547-1554. 14. Karagiorga I, Partsinevelos GA, Mavrogianni D, Anagnostou E, Zervomanolakis I, Kallianidis K, Drakakis P, Loutrdis D. Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile49Ser) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology. J Assist Reprod Genet 2015;32:357-367. 15. Greiber IK, Hagen CP, Busch AS, Mieritz MG, Aksglæde L, Main K, Almstrup K, Juul A. The AMH genotype (rs10407022 T> G) is associated with circulating AMH levels in boys, but not in girls. Endocr Connect 2018;7:347-354. 16. Čuš M, Vlaisavljević V, Repnik K, Potočnik U, Kovačič B. Could polymorphisms of some hormonal receptor genes, involved in folliculogenesis help in predicting patient response to controlled ovarian stimulation. J Assist Reprod Genet 2019;36:47-55. | ||
|
آمار تعداد مشاهده مقاله: 2,090 تعداد دریافت فایل اصل مقاله: 2,458 |
||
