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Malik, Saima Shakil, Mubarik, Sumaira, Baig, Mehreen, Masood, Nosheen, Chaudhry, Nayyer. (1397). Genetic polymorphism in ERCC5 and breast cancer risk. , 8(1), 27-31. doi: 10.22099/mbrc.2019.32294.1383
Saima Shakil Malik; Sumaira Mubarik; Mehreen Baig; Nosheen Masood; Nayyer Chaudhry. "Genetic polymorphism in ERCC5 and breast cancer risk". , 8, 1, 1397, 27-31. doi: 10.22099/mbrc.2019.32294.1383
Malik, Saima Shakil, Mubarik, Sumaira, Baig, Mehreen, Masood, Nosheen, Chaudhry, Nayyer. (1397). 'Genetic polymorphism in ERCC5 and breast cancer risk', , 8(1), pp. 27-31. doi: 10.22099/mbrc.2019.32294.1383
Malik, Saima Shakil, Mubarik, Sumaira, Baig, Mehreen, Masood, Nosheen, Chaudhry, Nayyer. Genetic polymorphism in ERCC5 and breast cancer risk. , 1397; 8(1): 27-31. doi: 10.22099/mbrc.2019.32294.1383

Genetic polymorphism in ERCC5 and breast cancer risk

Molecular Biology Research Communications
مقاله 4، دوره 8، شماره 1، 2019، صفحه 27-31    اصل مقاله (127.5 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2019.32294.1383
نویسندگان
Saima Shakil Malik* 1؛ Sumaira Mubarik2؛ Mehreen Baig3؛ Nosheen Masood1؛ Nayyer Chaudhry4
1Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, The Mall Rawalpindi
2Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China
3Surgical Unit, Fauji Foundation Hospital, Rawalpindi
4Armed Forces Institute of Pathology, Rawalpindi
چکیده
ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 females including one hundred breast cancer cases and age matched seventy-five healthy controls. Genotyping was performed with Tetra amplification-refractory mutation system (ARMS) PCR and products were observed through electrophoresis. Multivariate logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (95% CI) investigating relationship between genotypes, clinical parameters and risk of breast cancer. Statistical analysis exhibited significant relationship between the TC genotype (OR=7.2, 95% CI=1.5-34.3) and increased breast cancer risk. Moreover, family history (OR=6.25; 95% CI= 2.61-15.00) and late menopause (OR=2.41; 95% CI=1.20-4.83) were found to be breast cancer associated risk factors. In conclusion, ERCC5 (rs1047768 T>C) polymorphism may contribute towards increased risk of breast cancer in Pakistani population.
کلیدواژه‌ها
ERCC5؛ breast cancer؛ NER؛ ARMS-PCR
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