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Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population | ||
| Molecular Biology Research Communications | ||
| مقاله 4، دوره 8، شماره 4، 2019، صفحه 167-170 اصل مقاله (185.12 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2019.34904.1438 | ||
| نویسندگان | ||
| Nikhil Kirtipal* 1، 2؛ Hitender Thakur1، 2؛ Ranbir Chander Sobti1 | ||
| 1Department of Biotechnology, Panjab University, Chandigarh-160014, India | ||
| 2Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India | ||
| چکیده | ||
| This research aimed to explore the ACE (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of ACE (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001). | ||
| کلیدواژهها | ||
| ACE؛ COPD؛ Polymorphism؛ Genotype | ||
| مراجع | ||
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