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Kirtipal, Nikhil, Thakur, Hitender, Sobti, Ranbir Chander. (1398). Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population. , 8(4), 167-170. doi: 10.22099/mbrc.2019.34904.1438
Nikhil Kirtipal; Hitender Thakur; Ranbir Chander Sobti. "Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population". , 8, 4, 1398, 167-170. doi: 10.22099/mbrc.2019.34904.1438
Kirtipal, Nikhil, Thakur, Hitender, Sobti, Ranbir Chander. (1398). 'Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population', , 8(4), pp. 167-170. doi: 10.22099/mbrc.2019.34904.1438
Kirtipal, Nikhil, Thakur, Hitender, Sobti, Ranbir Chander. Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population. , 1398; 8(4): 167-170. doi: 10.22099/mbrc.2019.34904.1438

Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Molecular Biology Research Communications
مقاله 4، دوره 8، شماره 4، 2019، صفحه 167-170    اصل مقاله (185.12 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22099/mbrc.2019.34904.1438
نویسندگان
Nikhil Kirtipal* 1، 2؛ Hitender Thakur1، 2؛ Ranbir Chander Sobti1
1Department of Biotechnology, Panjab University, Chandigarh-160014, India
2Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India
چکیده
This research aimed to explore the ACE (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of ACE (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).  
کلیدواژه‌ها
ACE؛ COPD؛ Polymorphism؛ Genotype
مراجع

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