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Khoshnegah, J., Jamshidi, Sh., Mohammadi, M., Shojaee Tabrizi, A., Mohajerani, N., Zahraei Salehi, T.. (1387). Experimental infection of stray cats with human isolates of Helicobacter pylori. , 9(2), 150-157. doi: 10.22099/ijvr.2008.539
J. Khoshnegah; Sh. Jamshidi; M. Mohammadi; A. Shojaee Tabrizi; N. Mohajerani; T. Zahraei Salehi. "Experimental infection of stray cats with human isolates of Helicobacter pylori". , 9, 2, 1387, 150-157. doi: 10.22099/ijvr.2008.539
Khoshnegah, J., Jamshidi, Sh., Mohammadi, M., Shojaee Tabrizi, A., Mohajerani, N., Zahraei Salehi, T.. (1387). 'Experimental infection of stray cats with human isolates of Helicobacter pylori', , 9(2), pp. 150-157. doi: 10.22099/ijvr.2008.539
Khoshnegah, J., Jamshidi, Sh., Mohammadi, M., Shojaee Tabrizi, A., Mohajerani, N., Zahraei Salehi, T.. Experimental infection of stray cats with human isolates of Helicobacter pylori. , 1387; 9(2): 150-157. doi: 10.22099/ijvr.2008.539

Experimental infection of stray cats with human isolates of Helicobacter pylori

Iranian Journal of Veterinary Research
مقاله 7، دوره 9، شماره 2 - شماره پیاپی 23، 2008، صفحه 150-157    اصل مقاله (256.56 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2008.539
نویسندگان
J. Khoshnegah1؛ Sh. Jamshidi* 2؛ M. Mohammadi3؛ A. Shojaee Tabrizi2؛ N. Mohajerani3؛ T. Zahraei Salehi4
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
2Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
4Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
چکیده
To improve our understanding of Helicobacter  infection in cats and to determine whether they are reservoirs for H. pylori  and sources of zoonotic transmission to humans, we selected cats as an experimental animal model for gastric colonization by H. pylori. Sixteen stray cats underwent Helicobacter  eradication treatment followed by three consecutive oral inoculations of a cocktail of human H. pylori  isolates. Four out of sixteen inoculated cats became colonized by H. pylori  as confirmed by genus- and species-specific PCR. In conclusion, human  H. pylori  isolates are able to colonize the stomach of cats. It seems that the stray cat can be used as an experimental model in the future investigations of H. pylori -induced pathogenesis as well as evaluation of anti- H. pylori  prevention and treatment regimens. Further experimental studies using more animals are needed to identify the usefulness of the cat as an experimental model.
 
 
کلیدواژه‌ها
H. pylori؛ Colonization؛ PCR؛ Cat
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