Humic acid as a feed additive in poultry diets: a review

Abd El-Hack, ME and Alagawany, M (2015). Performance, egg quality, blood profile, immune function, and antioxidant enzyme activities in laying hens fed diets with thyme powder. J. Anim. Feed Sci., 24: 127-133.

Abdel-Mageed, M (2012). Effect of using organic acids on performance of japanese quail fed optimal and sub-optimal energy and protein levels 2. Butyric acid. Egypt. Poult. Sci. J., 32: 625-644.

Abdi, E; Babapour, S; Majnounian, B; Amiri, GZ and Deljouei, A (2018). How does organic matter affect the physical and mechanical properties of forest soil? J. For. Res., 29: 657-662.

Abdo, M and Zeinb, A (2004). Efficacy of acetic acid in improving the utilization of low protein-low energy broiler diets. Egypt. Poult. Sci. J., 24: 123-141.

Aksu, T and Bozkurt, AS (2009). Effect of dietary essential oils and/or humic acids on broiler performance, microbial population of intestinal content and antibody titres in the summer season. Kafkas Univ. Vet. Fak. Derg., 15: 185-190.

Alagawany, M and Abd El-Hack, ME (2015). The effect of rosemary herb as a dietary supplement on performance, egg quality, serum biochemical parameters, and oxidative status in laying hens. J. Anim. Feed Sci., 24: 341-347.

Alagawany, M; Abd El-Hack, ME; Farag, MR; Sachan, S; Karthik, K and Khama, K (2018). The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition. Environ. Sci. Pollut. Res. Int., 25: 10611-10618.

Arafat, RY; Khan, SH; Abbas, G and Iqbal, J (2015). Effect of dietary humic acid via drinking water on the performance and egg quality of commercial layers. Am. J. Biol. Life Sci., 3: 26-30.

Arafat, RY; Khan, SH and Baig, S (2017). Evaluation of humic acid as an aflatoxin binder in broiler chickens. Ann. Anim. Sci., 17: 241-255.

Arif, M; Rehman, A; Saeed, M; Abd El-Hack, ME; Arain, MA; Haseebarshad, M; Zakria, HM and Abbasi, IH (2016). Impacts of dietary humic acid supplementation on growth performance, some blood metabolites and carcass traits of broiler chicks. Indian J. Anim. Sci., 86: 1073-1078.

Arpášová, H; Kačániová, M; Pistová, V; Gálik, B; Fik, M and Hleba, L (2016). Effect of probiotics and humic acid on egg production and quality parameters of laying hens eggs. Anim. Sci. Biotechnol., 49: 1-9.

Cetin, E; Guclu, BK and Cetin, N (2011). Effect of dietary humate and organic acid supplementation on social stress induced by high stocking density in laying hens. J. Anim. Vet. Adv., 10: 2402-2407.

Ceylan, N; Ciftci, I and Ilhan, Z (2003). The effects of some alternative feed additives for antibiotic growth promoters on the performance and gut microflora of broiler chicks. Turk. J. Vet. Anim. Sci., 27: 727-733.

Chang-Hua, C; Jun-Jen, L; FungJou, L; Mei-Ling, Y; Yashang, L and Tien-Shang, H (2003). The effect of humic acid on the adhesibility of neutrophils. Thromb. Res., 108: 67-76.

Dabovich, L; Hulbert, L; Rudine, A; Ji, SKF and Mcglone, J (2003). Evaluation of nutriceutical effects on pig immunity: effects of promox. Proceedings of the 2003 Southern Section ASAS meeting. Pork Industry Institute, Department of Animal and Food Science, Texas Tech University, Lubbock, TX.79409.

Dhama, K; Latheef, SK; Mani, S; Abdul Samad, H; Karthik, K; Tiwari, R; Khan, RU; Alagawany, M; Mayada, RF; Alam, GM; Laudadio, V and Tufarelli, V (2015). Multiple beneficial applications and modes of action of herbs in poultry health and production. A review. Int. J. Pharmacol., 11: 152-176.

Dibner, JJ and Buttin, P (2002). Use of organic acids as a model to study the impact of gut microflora on nutrition and metabolism. J. Appl. Poult. Res., 11: 453-463.

Disetlhe, ARP; Marume, U; Mlambo, V and Dinev, I (2017). Humic acid and enzymes in canola-based broiler diets: effects on bone development, intestinal histomorphology and immune development. S. Afr. J. Anim. Sci., 47: 914-922.‏

Dobrzanski, Z; Trziska, T; Herbut, E; Krawczyk, J and Tronina, P (2009). Effect of humic preparations on productivity and quality traits of eggs from greenleg partridge hens. Ann. Anim. Sci., 9: 165-174.

Donoghue, DJ (2003). Antibiotic residues in poultry tissues and eggs: human health concerns? Poult. Sci., 82: 618-621.

Edmonds, MS; Johal, S and Moreland, S (2014). Effect of supplemental humic and butyric acid on performance and mortality in broilers raised under various environmental conditions. J. Appl. Poult. Res., 23: 260-267.

Ergin, O; Isa, C; Nuh, O and Guray, E (2009). Effects of dietary humic substances on egg production and egg shell quality of hens after peak laying period. Afr. J. Biotechnol., 8: 1155-1159.

Ertas, O; Ciftci, M; Girier, T and Dalkilic, B (2006). The use of possibility of mussel shell supplementation as calcium source in japanese quails raised under heat stress conditions: the effect of mussel shell on egg yield and some blood parameters. FU Saölik Bil. Dergisi. 20: 15-20.

Ghahri, H; Habibian, R and Fam, MA (2010). Evaluation of the efficacy of esterified glucomannan, sodium bentonite, and humic acid to ameliorate the toxic effects of aflatoxin in broilers. Turk. J. Vet. Anim. Sci., 34: 385-391.‏

Gomez-Rosales, S and Angeles, MD (2015). Addition of a worm leachate as source of humic substances in the drinking water of broiler chickens. Asian-Australas. J. Anim. Sci., 28: 215-222.

Griggs, JP and Jacob, JP (2005). Alternatives to antibiotics for organic poultry production. J. Appl. Poult. Res., 14: 750-756.

Hakan, K; Gultekin, Y and Ozge, S (2012). Effects of boric acid and humate supplementation on performance and egg quality parameters of laying hens. Rev. Bras. Cienc. Avic., 14: 283-289.

Huck, T; Porter, N and Bushell, M (1991). Effect of humates on microbial activity. Gen. Microbiol., 137: 2321-2329.

Humin, Tech (2004). Humin animal feed supplements and veterinary medicine and humic acid based products. Humintech-Humintech GmbH, Heerdter Landstr. 189/D, D-40549 Dusseldrof, Germany.

Ipek, H; Avci, M; Iriadam, M; Kaplan, O and Denek, N (2008). Effects of humic acid on some hematological parameters, total antioxidant capacity and laying performance in Japanese quails. Archiv. fur Geflugelkunde. 72: 56-60.‏

Islam, K; Schuhmacher, A; Aupperle, H and Gropp, J (2008). Fumaric acid in broiler nutrition: a dose titration study and safety aspects. Int. J. Poult. Sci., 7: 903-907.

Islam, K; Schuhmacher, A and Gropp, J (2005). Humic acid substances in animal agriculture. Pak. J. Nutr., 4: 126-134.

Kamel, MM; Elhady, M; El Iraqi, KG and Wahba, F (2015). Biologyical immune stimulants effects on immune response, behavioural and productive performance of broilers. Egypt. Poult. Sci. J., 35: 691-702.

Karaoğlu, M; Macit, M; Esenbuğa, N; Durdağ, H and Bilgin, ÖC (2004). Effect of dietary humate on performance, slaughter, carcass and meat quality parameters of broilers. Int. J. Poult. Sci., 6: 406-410.

Kaya, CA and Tuncer, SD (2009). The effects of humates on fattening performance, carcass quality and some blood parameters of broilers. J. Anim. Vet. Adv., 8: 281-284.

Klocking, R (1994). Humic substances as potential therapeutic. In: Senesi, N and Miano, TM (Eds.), Humic substances in the global environment and implications on human health. Proceedings of the 6th International Meeting of the International Humic Substances Society. Bari, Italy. September 20-25, 1992. 1368 PP., Amsterdam, Elsevier. P: 1368.

Kocabagli, N; Alp, M; Acar, N and Kahraman, R (2002). The effects of dietary humate supplementation on broiler growth and carcass yield. Poult. Sci., 81: 227-230.

Köksal, BH and Küçükersan, MK (2012). Effects of humate and plant extracts mixture addition to diets on performance and some blood parameters in laying hen rations. Ankara Üniv. Vet. Fak. Derg., 59: 121-128.

Kucukersan, S; Kucukersan, K; Colpan, I; Goncuoglu, E; Reisli, Z and Yesilbag, D (2005). The effects of humic acid on egg production and egg traits of laying hen. Vet. Med., 50: 406-410.

Miśta, D; Rząsa, A; Szmańko, T; Zawadzki, W; Styczyńska, M; Pintal, A and Króliczewska, B (2012). The effect of humic-fatty acid preparation on production parameters and meat quality of growing rabbits. Ann. Anim. Sci., 12: 117-126.‏

Mutus, R; Kocabagli, N; Alp, M; Acar, N; Eren, M and Gezen, SS (2006). The effect of dietary probiotic supplementation on tibial bone characteristics and strength in broilers. Poult. Sci., 85: 1621-1625.

Nagaraju, R; Reddy, BS; Gloridoss, R; Suresh, BN and Ramesh, C (2014). Effect of dietary supplementation of humic acids on performance of broilers. Indian J. Anim. Sci., 84: 447-452.‏

Ozturk, E and Coskun, I (2006). Effects of humic acids on broiler performance and digestive tract traits. Proceedings of the Book of Abstracts of the 57th Annual Meeting of the European Association for Animal Production. Antalya, Turkey. P: 301.

Ozturk, E; Coskun, I; Ocak, N; Erener, G; Dervisoglu, M and Turhan, S (2014). Performance, meat quality, meat mineral contents and caecal microbial population responses to humic substances administered in drinking water in broilers. Br. Poult. Sci., 55: 668-674.

Ozturk, E; Ocak, N; Coskun, I; Turhan, S and Erener, G (2010). Effects of humic substances supplementation provided through drinking water on performance, carcass traits and meat quality of broilers. J. Anim. Physiol. Anim. Nutr., 94: 78-85.

Parks, C; Ferket, P; Thomas, L and Grimes, J (1986). Growth performance and immunity of turkeys fed high and low crude protein diets supplemented with menefee humate. Poult. Sci., 75: 138-143.

Peña-Méndez, EM; Havel, J and Patočka, J (2005). Humic substances-compounds of still unknown structure: applications in agriculture, industry, environment, and biomedicine. J. Appl. Biomed., 3: 13-24.

Pistova, V; Arpášová, H and Hrnčár, C (2016). The effect of the humic acid and garlic (Allium sativum L.) on performance parameters and carcass characteristic of broiler chicken. J. Cent. Eur. Agric., 17: 1168-1178.‏

Rath, NC; Huff, WE and Huff, GR (2006). Effects of humic acid on broiler chickens. Poult. Sci., 85: 410-414.‏

Rath, NC; Richards, MP; Huff, WE; Huff, GR and Balog, JM (2005). Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. J. Comp. Pathol., 133: 41-52.

Riede, UN; Zeck-Kapp, G; Freudenberg, N; Keller, HU and Seubert, B (1991). Humate-induced activation of human granulocytes. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 60: 27-34.

Salah, H; Masour, ES; Reham, RR and El Hamid, ESA (2015). Study on the effect of humic acid on growth performance, immunological, some blood parameters and control intestinal closterdium in broiler chickens. Zag. Vet. J., 43: 102-109.

Schepetkin, IA; Khlebnikov, AI; Ah, SY; Woo, SB; Jeong, CS; Klubachuk, ON and Kwon, BS (2003). Characterization and biological activities of humic substances from mumie. J. Agric. Food Chem., 51: 5245-5254.‏

Shao, B and Heinecke, JW (2009). HDL, lipid peroxidation, and atherosclerosis. J. Lipid Res., 50: 599-601.

Shermer, CL; Maciorowski, KG; Bailey, CA; Byers, FM and Ricke, SC (1998). Caecal metabolites and microbial populations in chickens consuming diets containing a mined humate compound. J. Sci. Food Agric., 77: 479-486.

Sopoliga, I; Hreško-Šamudovská, A; Demeterová, M; Naď, P; Marcin, A and Skalická, M (2016). Effect of humic substances on the production parameters of pheasant hens. Acta Fytotechn. Zootechn., 19: 11-14.

Stepchenko, L; Zhorina, L and Kravtsova, L (1991). The effect of sodium humate on metabolism and resistance in highly productive poultry. Nauchnye Doki Vyss Shkoly Biol. Nauki., PP: 90-95 (in Russian).

Taklimi, SMSM; Ghahri, H and Isakan, MA (2012). Influence of different levels of humic acid and esterified glucomannan on growth performance and intestinal morphology of broiler chickens. Agric. Sci., 3: 663-668.

Ur Rehman, Z; Haq, AU; Akram, N; Abd El-Hack, ME; Saeed, M; Ur Rehman, S; Meng, C; Alagawany, M; Sayab, M; Dhama, K and Ding, C (2016). Growth performance, intestinal histomorphology, blood hematology and serum metabolites of broilers chickens fed diet supplemented with graded levels of acetic acid. Int. J. Pharmacol., 12: 874-883.

Wang, Q; Yoo, JS; Chen, YJ; Kim, HJ; Cho, JH; Min, BJ; Park, BC and Kim, IH (2006). Effects of supplemental humic substances on egg production and quality in laying hens. Korean J. Poult. Sci., 33: 317-321.

Windisch, W; Schedle, K; Plitzner, C and Kroismayr, A (2008). Use of phytogenic products as feed additives for swine and poultry. J. Anim. Sci., 86: E140-E148.

Yalcin, S; Ergun, A; Ozsoy, B; Yalcin, S; Erol, H and Onbasilar, I (2006). The effects of dietary supplementation of l-carnitine and humic substances on performance, egg traits and blood parameters in laying hens. Asian-Australas. J. Anim. Sci., 19: 1478-1483.

Yang, Hl; Chiu, HC and Lu, FJ (1996). Effects of humic acid on the viability and coagulant properties of human umbilical vein endothelial cells. Am. J. Hematol., 51: 200-206.

Yörük, MA; Gül, M; Hayirli, A and Macit, M (2004). The effects of supplementation of humate and probiotic on egg production and quality parameters during the late laying period in hens. Poult. Sci., 83: 84-88.

Young, KM and Foegeding, PM (1993). Acetic, lactic and citric acids and ph inhibition of listeria monocytogenes scott a and the effect on intracellular pH. J. Appl. Bacteriol., 74: 515-520.