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Pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 2، دوره 9، شماره 2 - شماره پیاپی 23، 2008، صفحه 121-126 اصل مقاله (188.88 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2008.533 | ||
| نویسندگان | ||
| D. Ram؛ V. K. Dumka* ؛ S. K. Sharma؛ H. S. Sandhu | ||
| Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India | ||
| چکیده | ||
| The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90 in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1.5%. High values of AUC (8.81 ± 0.37μg.h/ml) and Vdarea (1.06 ± 0.04 L/kg) reflected a vast area of body covered by drug concentration and appropriate penetration of levofloxacin into various body fluids and tissues. The elimination half-life and mean residence time were 3.27 ± 0.31 h and 5.4 ± 0.59 h, respectively. The total body clearance was 343.2 ± 14.1 ml/kg/h. An appropriate intramuscular dosage regimen for levofloxacin in buffalo calves would be 1.7 mg/kg repeated at 12-h intervals. | ||
| کلیدواژهها | ||
| Buffalo calves؛ Dosage؛ Intramuscular؛ Levofloxacin؛ pharmacokinetics | ||
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