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Repression-free utrophin-A 5’UTR variants | ||
| Molecular Biology Research Communications | ||
| مقاله 5، دوره 8، شماره 3، 2019، صفحه 129-133 اصل مقاله (1.02 M) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2019.34240.1421 | ||
| نویسندگان | ||
| Debasish Malik؛ Utpal Basu* | ||
| Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani, Nadia, 741235 India | ||
| چکیده | ||
| Mutation in the dystrophin gene results Duchenne Muscular Dystrophy (DMD), an X-linked fatal neuromuscular disorder. Dystrophin deficiency can be compensated by upregulation of utrophin, an autosomal homologue of dystrophin. But the expression of utrophin in adults is restricted to myotendinous and neuromuscular junctions. Therefore utrophin upregulation throughout the muscle fiber can only be achieved if we understand regulatory mechanisms behind its expression. Utrophin-A 5′UTR mediated repression of translation was reported earlier. In this article, we present evidences of two transcript variants of utrophin-A that do not confer repression to the downstream reporter ORF in mouse myoblast C2C12 cells. These repression-free variants may be targeted for utrophin upregulation. | ||
| کلیدواژهها | ||
| DMD؛ Utrophin؛ 5′RACE | ||
| مراجع | ||
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