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Association study of two single nucleotide polymorphisms rs10757278 and rs1333049 with atherosclerosis, a case-control study from Iraq | ||
| Molecular Biology Research Communications | ||
| مقاله 1، دوره 8، شماره 3، 2019، صفحه 99-102 اصل مقاله (145.63 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2019.33818.1406 | ||
| نویسندگان | ||
| Ahmed Abduljabbar Suleiman* 1؛ Hanan Yassin Muhsin2؛ Rafid A. Abdulkareem3؛ Farah Amer Abed4 | ||
| 1University of Anbar, College of Science, Iraq | ||
| 2University of Baghdad, College of Education for Pure Sciences (Ibn- AL-Haitham) | ||
| 3Department of Genetic Engineering, Institute of Genetic Engineering and Biotechnology for Post Graduate Studies, University of Baghdad, Baghdad, Iraq | ||
| 4Ministry of Science and Technology, Baghdad, Iraq | ||
| چکیده | ||
| Atherosclerosis is one of the most important coronary artery disease (CAD) caused by lipid accumulation, hypertension, smoking, and many other factors such as environmental and genetic factors. It has been recorded that genetic variations in rs10757278 and rs1333049 are correlated with CAD. In the present study, 100 blood samples were collected (50 CAD patients and 50 appeared to be healthy controls), who referred to Ibn-Albytar general hospital/in Bagdad city for heart disease from February to March 2019. Genotyping for two SNPs rs10757278 and rs1333049, were done by Tetra ARMS method. For the rs10757278 polymorphism, the GG genotype verses to AA genotype was significantly associated with the risk of CAD (OR=5.16, 95% CI:1.02-26.0, P=0.047). For the rs10757278 polymorphism, there was no significant associatin between genotypes and the susceptibiulity to CAD. In the present study, the rs10757278 polymorphism showed an association with CAD. | ||
| کلیدواژهها | ||
| rs10757278؛ rs1333049؛ Tetra ARMS؛ CAD؛ SNPs | ||
| مراجع | ||
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1. Ross R. Atherosclerosis an inflammatory disease. N Engl J Med 1999;340:115-126.
2. Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA; American Heart Association Council on Functional Genomics and Translational Biology; American Heart Association Council on Epidemiology and Prevention; American Heart Association Council on Basic Cardiovascular Sciences; American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Cardiovascular and Stroke Nursing; American Heart Association Stroke Council.Genetics and genomics for the prevention and treatment of cardiovascular disease:update: a scientific statement from the American Heart Association. Circulation 2013;128:2813-2851.
3. Miao L, Yin RX, Yang S, Huang F, Chen WX, Cao XL. Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke. Lipids Health Dis 2017;16:193.
4. Chen G, Fu X, Wang G, Liu G, Bai X. Genetic variant rs10757278 on chromosome 9p21 contributes to myocardial infarction susceptibility. Int J Mol Sci 2015;16:11678-11688.
5. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 2007;316:1491-1493.
6. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B. Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S,Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. N Engl J Med 2007;357:443-453.
7. Huang Y, Jin H, Yang G. A meta-analysis on associations of CDKN2B-AS variants with atherosclerotic cardio-cerebral vascular diseases. Life Sci 2018; doi:10.1016/j.lfs.2018.12. 047.
8. Xie Y, Zhao D, Dong P, Wang H, Li D, Lai L. Effects of ANRIL polymorphisms on the likelihood of coronary artery disease: A meta-analysis. J Cell Biochem 2019;120:6113-6119. | ||
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