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Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes | ||
| Molecular Biology Research Communications | ||
| مقاله 5، دوره 7، شماره 3، 2018، صفحه 133-141 اصل مقاله (227.13 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2018.29751.1325 | ||
| نویسندگان | ||
| Leila Karami-Gadallo1؛ Leila Ataie-Fashtami* 2؛ Mahmood Ghoranneviss3؛ Majid Pouladian4، 5؛ Dariush Sardari1 | ||
| 1Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Regenerative Medicine, Royan Institute for Stem Cell Biology & Technology, Tehran, Iran | ||
| 3Department of Plasma Physics, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 4Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 5Research Center of ‘Engineering in Medicine and Biology’, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Recently non-thermal plasma (NTP) is applied for many therapeutic applications. By NTP irradiating to the tissues or cell-lines, the water molecules (H2O) would be also activated leading to generate hydrogen peroxide (H2O2). By irradiating plasma to bio-solution, its main output including vacuum UV to UV causes the photolysis of H2O leading to generate hydroxyl (OH) molecules in couple forms with ability to convert to H2O2. Additionally, other plasma’s output the oxygen atoms could also penetrate under the liquid’s surface and react with H2O to generate H2O2. In NTP applications for killing unwanted-cells of microorganisms (e.g. sterilization) or cancerous tissues, the H2O2 molecule is the main reactive species for cell death via inducing DNA damage in mammalian cells. In this paper we proposed a mathematical model for NTP application describing the formation of hydroxyls in the bio solution and other subsequent reactions leading to DNA damage in vitro. The instant concentrations of the OH and H2O2, the main species for DNA oxidation were obtained and investigated in this simulation. In order to validate the model, the cellular response to NTP stimulation was compared with some experimental findings from viewpoint of DNA damage to show the significant consistency. | ||
| کلیدواژهها | ||
| Modeling؛ DNA damage؛ hydroxyl؛ peroxide؛ non-thermal plasma | ||
| مراجع | ||
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