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Karami-Gadallo, Leila, Ataie-Fashtami, Leila, Ghoranneviss, Mahmood, Pouladian, Majid, Sardari, Dariush. (1397). Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes. , 7(3), 133-141. doi: 10.22099/mbrc.2018.29751.1325
Leila Karami-Gadallo; Leila Ataie-Fashtami; Mahmood Ghoranneviss; Majid Pouladian; Dariush Sardari. "Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes". , 7, 3, 1397, 133-141. doi: 10.22099/mbrc.2018.29751.1325
Karami-Gadallo, Leila, Ataie-Fashtami, Leila, Ghoranneviss, Mahmood, Pouladian, Majid, Sardari, Dariush. (1397). 'Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes', , 7(3), pp. 133-141. doi: 10.22099/mbrc.2018.29751.1325
Karami-Gadallo, Leila, Ataie-Fashtami, Leila, Ghoranneviss, Mahmood, Pouladian, Majid, Sardari, Dariush. Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes. , 1397; 7(3): 133-141. doi: 10.22099/mbrc.2018.29751.1325

Cell damaging by irradiating non-thermal plasma to the water: Mathematical modeling of chemical processes

Molecular Biology Research Communications
مقاله 5، دوره 7، شماره 3، 2018، صفحه 133-141    اصل مقاله (227.13 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2018.29751.1325
نویسندگان
Leila Karami-Gadallo1؛ Leila Ataie-Fashtami* 2؛ Mahmood Ghoranneviss3؛ Majid Pouladian4، 5؛ Dariush Sardari1
1Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Regenerative Medicine, Royan Institute for Stem Cell Biology & Technology, Tehran, Iran
3Department of Plasma Physics, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
5Research Center of ‘Engineering in Medicine and Biology’, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Recently non-thermal plasma (NTP) is applied for many therapeutic applications. By NTP irradiating to the tissues or cell-lines, the water molecules (H2O) would be also activated leading to generate hydrogen peroxide (H2O2). By irradiating plasma to bio-solution, its main output including vacuum UV to UV causes the photolysis of H2O leading to generate hydroxyl (OH) molecules in couple forms with ability to convert to H2O2. Additionally, other plasma’s output the oxygen atoms could also penetrate under the liquid’s surface and react with H2O to generate H2O2. In NTP applications for killing unwanted-cells of microorganisms (e.g. sterilization) or cancerous tissues, the H2O2 molecule is the main reactive species for cell death via inducing DNA damage in mammalian cells. In this paper we proposed a mathematical model for NTP application describing the formation of hydroxyls in the bio solution and other subsequent reactions leading to DNA damage in vitro. The instant concentrations of the OH and H2O2, the main species for DNA oxidation were obtained and investigated in this simulation. In order to validate the model, the cellular response to NTP stimulation was compared with some experimental findings from viewpoint of DNA damage to show the significant consistency.
کلیدواژه‌ها
Modeling؛ DNA damage؛ hydroxyl؛ peroxide؛ non-thermal plasma
مراجع

1. Kong MG, Kroesen G, Morfill G, Nosenko T, Shimizu T, Dijk JV, Zimmermann JL. Plasma medicine: an introductory review. New J Phys 2009;11:115012.

2. Reuter S, Woedtke TV, Weltmann KD. The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications. J Phys D App Phys 2018;51: 233001.

3. Valko M, Leibfritz D, Moncola J, Cronin MTD, Mazura M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44.

4. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied plasma medicine. Plasma Processes Polym 2008;5:503.

5. Attri P, Kim YH, Park DH, Park JH, Hong YJ, Uhm HS, Kim KN, Fridman A, Choi EH. Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet (UV) photolysis. Sci Rep 2015;5:9332.

6. Yusupov M et al. Reactive molecular dynamics simulations of oxygen species in a liquid water layer of interest for plasma medicine. J Phys D Appl Phys 2013;47:025205.

7. Tian W, Kushner MJ. Atmospheric pressure dielectric barrier discharges interacting with liquid covered tissue. J Phys D Appl Phys 2014;47:165201.

8. Uhl L, Gerstel A, Chabalier M, Dukan S. Hydrogen peroxide induced cell death: One or two modes of action? Heliyon 2015; e00049

9. Halliwell B. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition. Mutat Res 1999;443: 37-52.

10. Mello-Filho AC, Hoffmann ME, Meneghini R. Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron. Biochem J 1984;218:273-275.

11. Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-1208.

12. Atkinson, Kendall A. (1989). An Introduction to Numerical Analysis (2nd ed.). New York: John Wiley & Sons. ISBN 978-0-471-50023-0

13. Toyokuni S. Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci 2009; 100:9-16.

14. Valko M, Rhodes C, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40.

15. Toyokuni S. Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep 2002;7:189-197.

16. Babbs CF. Free radicals and the etiology of colon cancer. Free Radic Biol Med 1990;8:191-200

17. Duthie SJ, Collins AR. The influence of cell growth ,detoxifying enzyms and DNA repair on hydrogen peroxide mediate and damage (measured using comet assay) in human cells. Free Radic Biol Med 1997;22:717-724.

18. Vilema-Enríquez G, Arroyo A, Grijalva M, Amador-Zafra RI, Camacho J. Molecular and cellular effects of hydrogen peroxide on human lung cancer cells: Potential therapeutic implications. Oxid Med Cel Longev 2016;2016:1908164.

19. Kieft E, Laan E, Stoffels E. Electrical and optical characterization of the plasma needle. New J Phys 2004;6:149.

20. Martines E, Zuin M, Cavazzana R, Gazza E, Serianni G, Spagnolo S, Leonardi A, Deligianni V, Burn P. A novel plasma source for sterilization of living tissues. New J Phys 2009;11:115014.

21. Karami-Gadallo L, Ghorannevis M, Ataie-Fashtami L, Pouladian M, Sardari D. Enhancem-ent of cancerous cells treatment by applying cold atmospheric plasma and photo dynamic therapy simultaneously. Clin Plasm Medic 2017;7-8:46-51.

22. Balzer J, Heuer K, Demir E, Hoffmanns MA, Baldus S, Fuchs PC, Awakowicz P, Suschek CV, Oplander C. Non-thermal dielectric barrier discharge (DBD) efects on proliferation and differentiation of human fibroblasts are primary mediated by hydrogen peroxide. PLoS One 2015;10:e0144968.

23. Boselli M, Colombo V, Ghedini E, Gherardi M, Laurita R, Liguiri A, Sanibondi P, Stancampiano A. Characterization of a plasma jet for biomedical applications:composition, temperature, fluid dynamics and plasma structure. ISPC Conf. Proc.2009; 810: 40123.

24. Laroussia M, Lu X. Room-temperature atmospheric pressure plasma plume for biomedical applications. Appl Phys Lett 2005;87:113902.

25. Shaer M, Zaki A., Reda AM, Adel M, Mobasher M, Ali S. Effect of plasma activated mist on breast cancer cells. IEEE Tr Rad Plasm Med Sci 2018;2

26. Chen Z, Lin L, Cheng X, Gjika E, Keider M. Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy. Plasm Proces Polym 2016;13:11511156

27. Kalghatgi S, Fridman A, Clifford JA, Friedman G. DNA damage in mammalian cells by non-thermal atmospheric pressure microsecond pulsed dielectric barrier discharge plasma is not mediated by Ozone. Plasma Proc Polym 2012;9:726-732.

28. Zhang S, Li C, Gao J, Qiu X, Cui Z. Application of the Ca2+ indicator flo-3 and flo-4 in the process of H2O2 induced apoptosis of A549 cell. Chin J Lung Cancer 2014;17:197-202.

29. Chua PJ, Yip GWC, Bay BH. Cell cycle arrest induced by hydrogen peroxide is associated with modulation of oxidative stress related genes in breast cancer cells. Exper Biol Med 2009; 234:1086–1094.

30. Liu SL, Lin X, Shi DY, Cheng J, Wu CQ, Zhang YD. Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. Arch Bioch Biophys 2002; 406:173-182.

31. Park IJ, Hwang JT, Young MK, Ha J, Ock JP. Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancercells. Ann New York Acad Sci 2006; 1091:102-109.

32. Upadhyay D, Chang W, Wei K, Gao M, Rosen GD. Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases. FEBS Lett 2007;581:248-252.

33. Heit G, Neuner A, Saugy PY, Braun AM. Vacuum-UV (172 nm) actinometry. The quantum yield of the photolysis of water.  J Phys Chem 1998;102:5551-5561.

34. Maddena KP, Mezyka SP. Critical review of aqueous solution reaction rate constants for hydrogen atoms. J Phys Chem 2011; Ref. Data 40 023103

35. Halliwell B, Aruoma OI. DNA damage by oxygen-derived species: Its mechanism and measurement in mammalian systems. FEBS Lett 1991;281:9-19.

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