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Ebrahimi, Samira, Mohabatkar, Hassan. (1396). Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria. , 7(1), 35-41. doi: 10.22099/mbrc.2018.28775.1308
Samira Ebrahimi; Hassan Mohabatkar. "Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria". , 7, 1, 1396, 35-41. doi: 10.22099/mbrc.2018.28775.1308
Ebrahimi, Samira, Mohabatkar, Hassan. (1396). 'Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria', , 7(1), pp. 35-41. doi: 10.22099/mbrc.2018.28775.1308
Ebrahimi, Samira, Mohabatkar, Hassan. Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria. , 1396; 7(1): 35-41. doi: 10.22099/mbrc.2018.28775.1308

Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria

Molecular Biology Research Communications
مقاله 5، دوره 7، شماره 1، 2018، صفحه 35-41    اصل مقاله (107.52 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2018.28775.1308
نویسندگان
Samira Ebrahimi؛ Hassan Mohabatkar*
Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
چکیده
Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development. Nineteen different M proteins of different streptococcal bacteria were chosen and analyzed. Nine-mer epitopes able to simulate both cells mediate and humoral immunity were predicted. Molecular docking was applied in order to measure free binding energy of selected epitopes. Final epitopes were analyzed if they were conserved among different streptococcal bacteria. The identified epitopes require experimental validation for their potential use in peptide vaccines.
کلیدواژه‌ها
Epitope prediction؛ Molecular docking؛ M protein؛ Streptococcal bacteria؛ Vaccine design
مراجع

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