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The association between NFKB1 -94ATTG ins/del and NFKB1A -826C/T genetic variations and coronary artery disease risk | ||
| Molecular Biology Research Communications | ||
| مقاله 3، دوره 7، شماره 1، 2018، صفحه 17-24 اصل مقاله (202.99 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2018.28261.1302 | ||
| نویسندگان | ||
| Abbas Seidi1؛ Sina Mirzaahmadi1؛ Khalil Mahmoodi2؛ Mohammad Soleiman Soltanpour* 3 | ||
| 1Department of Genetic, Faculty of Basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran | ||
| 2Department of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| 3Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran | ||
| چکیده | ||
| Coronary artery disease (CAD) is considered as a chronic inflammatory disease initiated from early childhood. Nuclear factor κB (NF κB) and κB1A (NF κB1A) are the key regulators of inflammatory responses. The NFKB1 -94ATTG ins/del and NFKB1A -826C/T polymorphisms may contribute to the development of CAD. The aim of the present study was to investigate the association of these polymorphisms with the risk of CAD. The study population included 120 patients with angiographically confirmed CAD and 100 matched controls. Genotyping of NFKB1 -94ATTG ins/del and NFKB1A -826C/T polymorphism was performed using PCR-RFLP method. Lipid level was determined by routine colorimetric methods. Statistical analysis was done by SPSS 16 software. Results indicated that the genotypic (P=0.041) and allelic (P=0.009) distribution of the NFKB1-94ATTG ins/del polymorphism was significantly different between the two groups. In the univariate analysis (ins/ins genotype as reference), the del/del genotype (OR=2.88, 95% CI=1.21-6.84, P=0.015) but not ins/del genotype (OR=1.48, 95% CI=0.83-2.64, P=0.191) was significantly associated with the increased risk of CAD. In the multiple binary logistic regression analysis, diabetes, hypertension, smoking, LDL-cholesterol, total cholesterol, HDL-cholesterol and NFKB1 -94ATTG del/del genotype were identified as significant and independent risk factors for CAD development. The distribution of genotypes and alleles of NFKB1A -826C/T polymorphism was not significantly different between the two groups. In conclusion the present study identified NFKB1 -94ATTG ins/del polymorphism but not NFKB1A -826C/T polymorphism as a significant and independent risk factor for development and severity of CAD. | ||
| کلیدواژهها | ||
| Coronary artery disease؛ Nuclear factor κB؛ Polymorphism | ||
| مراجع | ||
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1. Fragakis N, Ioannidou E, Bounda A, Theodoridou S, Klonizakis P, Garipidou V. Increased levels of proinflammatory cytokines in children with family history of coronary artery disease. Clin Cardiol 2010;33:6-10. 2. Lai HM, Li XM, Yang YN, Ma YT, Xu R, Pan S, Zhai H, Liu F, Chen BD, Zhao Q. Genetic variation in NFKB1 and NFKBIA and susceptibility to coronary artery disease in a Chinese Uygur population. PLoS One 2015;10:e0129144. 3. Gao M, Wang CH, Sima X, Han XM. NFKB1-94 insertion/deletion ATTG polymorphism contributes to risk of systemic lupus erythematosus. DNA Cell Biol 2012;31:611-615. 4. Borm ME, Bodegraven AA, Mulder CJ, Kraal G, Bouma G. A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis. Int J Immunogenet 2005;32: 401-405. 5. Kurylowicz A, Hiromatsu Y, Jurecka-Lubieniecka B, Kula D, Kowalska M, Ichimura M, Koga H, Kaku H, Bar-Andziak E, Nauman J, Jarzab B. Association of NFKB1-94ins/del ATTG promoter polymorphism with susceptibility to and phenotype of Graves' disease. Genes Immun 2007;8:532-538. 6. Oeckinghaus A, Ghosh S. The NF-κB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009;1:a000034. 7. Héron E, Deloukas P, van Loon AP. The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-κB and IκB-γ: implications for NF-κB-mediated signal transduction. Genomics 1995;30:493-505. 8. Karin M, Delhase M. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin Immunol 2000;12:85-98. 9. Lai H, Chen Q, Li X, Ma Y, Xu R, Zhai H, Liu F, Chen B, Yang Y. Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population. Int J Clin Exp Med 2015;8:21487-21496. 10. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004;13:35-45. 11. Duan W, Wang E, Zhang F, Wang T, You X, Qiao B. Association between the NFKB1-94ins/del ATTG polymorphism and cancer risk: an updated meta-analysis. Cancer Invest 2014;32:311-320. 12. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer 2013;12:86. 13. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappaB. Annu Rev Cell Biol 1994;10:405-455. 14. Özbilüm N, Arslan S, Berkan Ö, Yanartaş M, Aydemir EI. The role of NF‐κB1A promoter polymorphisms on coronary artery disease risk. Basic Clin Pharmacol Toxicol 2013;113: 187-192. 15. Zhang M, Huang J, Tan X, Bai J, Wang H, Ge Y, Xiong H, Shi J, Lu W, Lv Z, Liang C. Common polymorphisms in the NFKBIA gene and cancer susceptibility: a meta-analysis. Med Sci Monit 2015;21:3186-3196. 16. Ali S, Hirschfeld AF, Mayer ML, Fortuno ES, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L. Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia. J Immunol 2013;190:3949-3958. 17. Soltanpour MS, Soheili Z, Pourfathollah AA, Samiei S, Meshkani R, Kiani AA, Majid S, Ataei Z, Kavari M. The A1298C mutation in methylenetetrahydrofolate reductase gene and its association with idiopathic venous thrombosis in an Iranian population. Lab Med 2015; 42:213-216. 18. Arslan S, Korkmaz Ö, Özbilüm N, Berkan Ö. Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease. Biomed Rep 2015;3:736-740. 19. Chen QJ, Lai HM, Zhao L, Ma YT, Li XM, Zhai H, Zhou Y, He CH, Chen BD, Liu F, Yang YN. Association between the NFKB1-94ins/del ATTG polymorphism (rs28362491) and coronary artery disease: A systematic review and meta-analysis. Genet Test Mol Biomarkers 2016;20:105-111. 20. Luo JY, Li XM, Zhou Y, Zhao Q, Chen BD, Liu F, Chen XC, Zheng H, Ma YT, Gao XM, Yang YN. Mutant DD genotype of NFKB1 gene is associated with the susceptibility and severity of coronary artery disease. J Mol Cell Cardiol 2017;103:56-64. 21. Oner T, Arslan C, Yenmis G, Arapi B, Tel C, Aydemir B, Sultuybek GK. Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis. J Genet 2017;96:251-259. 22. Boccardi V, Rizzo MR, Marfella R, Papa M, Esposito A, Portoghese M, Paolisso G, Barbieri M. -94 ins/del ATTG NFKB1 gene variant is associated with lower susceptibility to myocardial infarction. Nutr Metab Cardiovasc Dis 2011;21:679-684. 23. Miller J, Schwarz W. Aggregate and individual replication probability within an explicit model of the research process. Psychol Methods 2011;16:337-360. 24. Youssef MR, Attia ZI, El-Baz RA, Roshdy S, Settin A. Genetic polymorphisms of NFκB1-94ins/delATTG and NFκBIA -881A/G genes in Egyptian patients with colorectal cancer. Fam Cancer 2017:16;517-524. 25. Vogel U, Jensen MK, Due KM, Rimm EB, Wallin H, Nielsen MR, Pedersen AP, Tjønneland A, Overvad K. The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. Atherosclerosis 2011;219:200-204. 26. Cui X, Yan H, Ou TW, Jia CS, Wang Q, Xu JJ. Genetic variations in inflammatory response genes and their association with the risk of prostate cancer. Biomed Res Int 2015;2015: 674039. Doi:10.1155/2015/674039. | ||
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