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Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran | ||
| Molecular Biology Research Communications | ||
| مقاله 4، دوره 6، شماره 3، 2017، صفحه 123-126 اصل مقاله (58.51 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2017.25056.1261 | ||
| نویسندگان | ||
| Mansour Shakiba1، 2؛ Mohammad Hashemi* 3، 4؛ Salah Mahdar2؛ Zahra Rahbari2؛ Gholamreza Bahari4 | ||
| 1Health promotion research Center, Zahedan University of Medical Sciences, Zahedan, Iran | ||
| 2Department of Psychiatry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | ||
| 3Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran | ||
| 4Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | ||
| چکیده | ||
| The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method. Totally, the findings did not support an association between DAT1 VNTR polymorphisms and the risk of BD in a sample of southeast Iranian population. | ||
| کلیدواژهها | ||
| Bipolar disorder؛ dopamine transporter؛ DAT1؛ VNTR؛ Polymorphism | ||
| مراجع | ||
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